Developing the ATX(N) classification for use across the Alzheimer disease continuum

Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology

(2021) Nicholas J. Ashton et al.   ACTA NEUROPATHOLOGICA

The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up

(2020) Gøril Rolfseng Grøntvedt et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia

(2020) Shorena Janelidze et al.   NATURE MEDICINE

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

(2020) Elisabeth H. Thijssen et al.   NATURE MEDICINE

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

(2020) Thomas K Karikari et al.   LANCET NEUROLOGY

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Research criteria for the diagnosis of prodromal dementia with Lewy bodies

(2020) Ian G. McKeith et al.   NEUROLOGY

The implications of different approaches to define AT(N) in Alzheimer disease

(2020) Niklas Mattsson-Carlgren et al.   NEUROLOGY

Imaging biomarkers in neurodegeneration: current and future practices

(2020) Peter N. E. Young et al.   Alzheimers Research & Therapy

Longitudinal trajectories of Alzheimer’s ATN biomarkers in elderly persons without dementia

(2020) Meng-Shan Tan et al.   Alzheimers Research & Therapy

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease

(2020) Niklas Mattsson-Carlgren et al.   Science Advances

First amyloid β1‐42 certified reference material for re‐calibrating commercial immunoassays

(2020) Sébastien Boulo et al.   Alzheimers & Dementia

AD risk score for the early phases of disease based on unsupervised machine learning

(2020) Zheyu Wang et al.   Alzheimers & Dementia

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

ATN classification and clinical progression in subjective cognitive decline

(2020) Jarith L. Ebenau et al.   NEUROLOGY

Inexpensive, non-invasive biomarkers predict Alzheimer transition using machine learning analysis of the Alzheimer’s Disease Neuroimaging (ADNI) database

(2020) Juan Felipe Beltrán et al.   PLoS One

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

(2020) Martin Tolar et al.   Alzheimers Research & Therapy

Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease

(2020) Niklas Mattsson-Carlgren et al.   BRAIN

Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

(2020) Daniel Lancour et al.   Alzheimers Research & Therapy

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

(2019) Oliver Preische et al.   NATURE MEDICINE

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer’s Precision Medicine and Pharmacology

(2019) Harald Hampel et al.   Frontiers in Pharmacology

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

(2019) Gemma Salvadó et al.   Alzheimers Research & Therapy

ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes

(2019) Anja Soldan et al.   NEUROLOGY

Identification of a Simple and Novel Cut-Point Based Cerebrospinal Fluid and MRI Signature for Predicting Alzheimer’s Disease Progression that Reinforces the 2018 NIA-AA Research Framework

(2019) Priya Devanarayan et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory biomarkers in Alzheimer's disease plasma

(2019) Angharad R. Morgan et al.   Alzheimers & Dementia

Elecsys® Total-Tau and Phospho-Tau (181P) CSF assays: Analytical performance of the novel, fully automated immunoassays for quantification of tau proteins in human cerebrospinal fluid

(2019) Valeria Lifke et al.   CLINICAL BIOCHEMISTRY

NFL is a marker of treatment response in children with SMA treated with nusinersen

(2019) Bob Olsson et al.   JOURNAL OF NEUROLOGY

Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease

(2019) Niklas Mattsson et al.   JAMA Neurology

Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease

(2019) Val J. Lowe et al.   Alzheimers & Dementia

Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia

(2019) Clifford R. Jack et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CSF and blood biomarkers for Parkinson's disease

(2019) Lucilla Parnetti et al.   LANCET NEUROLOGY

Neuroimaging Biomarkers for Alzheimer’s Disease

(2019) Freddie Márquez et al.   Molecular Neurodegeneration

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease

(2019) Harald Hampel et al.   PROGRESS IN NEUROBIOLOGY

Towards a unified protocol for handling of CSF before β-amyloid measurements

(2019) Shorena Janelidze et al.   Alzheimers Research & Therapy

Amyloid-β PET—Correlation with cerebrospinal fluid biomarkers and prediction of Alzheimer´s disease diagnosis in a memory clinic

(2019) Ebba Gløersen Müller et al.   PLoS One

Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias

(2019) Anna Antonell et al.   Alzheimers & Dementia

Tau-positron emission tomography correlates with neuropathology findings

(2019) Val J. Lowe et al.   Alzheimers & Dementia

Cerebrospinal fluid proteomics and biological heterogeneity in Alzheimer’s disease: A literature review

(2019) Kirsten E. J. Wesenhagen et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Biomarker-guided clustering of Alzheimer's disease clinical syndromes

(2019) Nicola Toschi et al.   NEUROBIOLOGY OF AGING

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography

(2018) Michelle M. Mielke et al.   Alzheimers & Dementia

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts

(2018) Oskar Hansson et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

The National Institute on Aging—Alzheimer's Association Framework on Alzheimer's disease: Application to clinical trials

(2018) Jeffrey Cummings   Alzheimers & Dementia

The importance of endpoint selection: How effective does a drug need to be for success in a clinical trial of a possible Alzheimer’s disease treatment?

(2018) Stephanie Evans et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

(2018) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Biomarkers for Alzheimer's disease: current status and prospects for the future

(2018) K. Blennow et al.   JOURNAL OF INTERNAL MEDICINE

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

(2018) Harald Hampel et al.   Nature Reviews Neurology

Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology-based cohort

(2017) G. G. Kovacs et al.   EUROPEAN JOURNAL OF NEUROLOGY

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Whole genome sequence analyses of brain imaging measures in the Framingham Study

(2017) Chloé Sarnowski et al.   NEUROLOGY

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

(2017) Mohammad Shahnawaz et al.   JAMA Neurology

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease

(2017) Niklas Mattsson et al.   JAMA Neurology

Neuroimaging in pre-motor Parkinson's disease

(2017) Thomas R. Barber et al.   NeuroImage-Clinical

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials

(2016) Jeff Sevigny et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid (1–42) in human cerebrospinal fluid

(2016) Tobias Bittner et al.   Alzheimers & Dementia

Round robin test on quantification of amyloid-β 1–42 in cerebrospinal fluid by mass spectrometry

(2016) Josef Pannee et al.   Alzheimers & Dementia

Imaging biomarker roadmap for cancer studies

(2016) James P. B. O'Connor et al.   Nature Reviews Clinical Oncology

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Who has undiagnosed dementia? A cross-sectional analysis of participants of the Aging, Demographics and Memory Study

(2015) G. M. Savva et al.   AGE AND AGEING

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

(2015) William E. Klunk et al.   Alzheimers & Dementia

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Alzheimer Disease Cerebrospinal Fluid Biomarkers Moderate Baseline Differences and Predict Longitudinal Change in Attentional Control and Episodic Memory Composites in the Adult Children Study

(2015) Andrew J. Aschenbrenner et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease

(2015) Sebastian Palmqvist et al.   NEUROLOGY

A Practical Guide to Immunoassay Method Validation

(2015) Ulf Andreasson et al.   Frontiers in Neurology

Genetic modification of the relationship between phosphorylated tau and neurodegeneration

(2014) Timothy J. Hohman et al.   Alzheimers & Dementia

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

The Preclinical Alzheimer Cognitive Composite

(2014) Michael C. Donohue et al.   JAMA Neurology

Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series

(2013) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later

(2013) C. M. Roe et al.   NEUROLOGY

Common Alzheimer’s Disease Research Ontology: National Institute on Aging and Alzheimer’s Association Collaborative Project

(2012) Lorenzo M. Refolo et al.   Alzheimers & Dementia

Rationale for use of the Clinical Dementia Rating Sum of Boxes as a primary outcome measure for Alzheimer’s disease clinical trials

(2012) Jesse M. Cedarbaum et al.   Alzheimers & Dementia

Underdiagnosis of dementia in primary care: Variations in the observed prevalence and comparisons to the expected prevalence

(2011) Amanda Connolly et al.   AGING & MENTAL HEALTH

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: methods of the EGAPP Working Group

(2009) Steven M Teutsch et al.   GENETICS IN MEDICINE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY