Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids

Concise Total Synthesis of (+)-Asperazine, (+)-Pestalazine A, and (+)-iso-Pestalazine A. Structure Revision of (+)-Pestalazine A

(2016) Richard P. Loach et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

(2016) Akira Nakagawa et al.   Nature Communications

Metabolic engineering for the production of plant isoquinoline alkaloids

(2015) Andrew Diamond et al.   PLANT BIOTECHNOLOGY JOURNAL

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete biosynthesis of opioids in yeast

(2015) S. Galanie et al.   SCIENCE

Cytochrome P450 as Dimerization Catalyst in Diketopiperazine Alkaloid Biosynthesis

(2014) Takayoshi Saruwatari et al.   CHEMBIOCHEM

Making iridoids/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation

(2014) Vincenzo De Luca et al.   CURRENT OPINION IN PLANT BIOLOGY

Identification of cellular and molecular factors determining the response of cancer cells to six ergot alkaloids

(2014) Marco Mrusek et al.   INVESTIGATIONAL NEW DRUGS

A new diketopiperazine heterodimer from an endophytic fungusAspergillus niger

(2014) Xiao-Bin Li et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

A microbial biomanufacturing platform for natural and semisynthetic opioids

(2014) Kate Thodey et al.   Nature Chemical Biology

Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae

(2014) Elena Fossati et al.   Nature Communications

The seco-iridoid pathway from Catharanthus roseus

(2014) Karel Miettinen et al.   Nature Communications

(R,S)-Tetrahydropapaveroline production by stepwise fermentation using engineered Escherichia coli

(2014) Akira Nakagawa et al.   Scientific Reports

Cyclolization of D-Lysergic Acid Alkaloid Peptides

(2013) Judith Havemann et al.   CHEMISTRY & BIOLOGY

Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk

(2013) Yuta Tsunematsu et al.   Nature Chemical Biology

Partial Reconstruction of the Ergot Alkaloid Pathway by Heterologous Gene Expression in Aspergillus nidulans

(2013) Katy Ryan et al.   Toxins

Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases

(2012) J. K. Michener et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Older Blood Pressure Medications—Do They Still Have a Place?

(2011) Hanna B. Slim et al.   AMERICAN JOURNAL OF CARDIOLOGY

Heterologous expression of two FAD-dependent oxidases with (S)-tetrahydroprotoberberine oxidase activity from Arge mone mexicana and Berberis wilsoniae in insect cells

(2011) Andreas Gesell et al.   PLANTA

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

Development and refinement of a high-efficiency gene-targeting system for Aspergillus flavus

(2010) Perng-Kuang Chang et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms

(2010) Kento Koketsu et al.   Nature Chemical Biology

Concise total synthesis and structural revision of (+)-pestalazine B

(2010) Carlos Pérez-Balado et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Combinatorial Assembly of Simple and Complex d-Lysergic Acid Alkaloid Peptide Classes in the Ergot FungusClaviceps purpurea

(2009) Ingo Ortel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

Naseseazines A and B: A New Dimeric Diketopiperazine Framework from a Marine-Derived Actinomycete,Streptomycessp.

(2009) Ritesh Raju et al.   ORGANIC LETTERS

The Ehrlich Pathway for Fusel Alcohol Production: a Century of Research on Saccharomyces cerevisiae Metabolism

(2008) L. A. Hazelwood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Pestalazines and Pestalamides, Bioactive Metabolites from the Plant Pathogenic FungusPestalotiopsis theae

(2008) Gang Ding et al.   JOURNAL OF NATURAL PRODUCTS

Progress in Metabolic Engineering of Saccharomyces cerevisiae

(2008) E. Nevoigt   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Coupling of Catharanthine and Vindoline to Provide Vinblastine:  Total Synthesis of (+)- andent-(−)-Vinblastine

(2007) Hayato Ishikawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strictosidine Synthase:  Mechanism of a Pictet−Spengler Catalyzing Enzyme†

(2007) Justin J. Maresh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY