期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 17, 期 2, 页码 182-187出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2014.959939
关键词
Aspergillus niger; endophytic fungus; alpha-pyrone; cytotoxicity; diketopiperazine heterodimer
资金
- National Natural Science Foundation of China [81273383, 21272139]
One new diketopiperazine heterodimer, asperazine A (1), and eight known compounds, asperazine (2), cyclo(d-Phe-l-Trp) (3), cyclo(l-Trp-l-Trp) (4), 4-(hydroxymethyl)-5,6-dihydro-pyran-2-one (5), walterolactone A (6), and campyrones A-C (7-9), were isolated from an endophytic fungus Aspergillus niger. Their structures were determined unequivocally on the basis of extensive spectroscopic data analysis. This is the first report of the presence of compound 3 as a natural product. Cytotoxicity test against human cancer cell lines PC3, A2780, K562, MBA-MD-231, and NCI-H1688 revealed that compounds 1 and 2 had weak activities.
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