Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice

Folic Acid Plus α-Tocopherol Mitigates Amyloid-β-Induced Neurotoxicity through Modulation of Mitochondrial Complexes Activity

(2018) Cláudia P. Figueiredo et al.   JOURNAL OF ALZHEIMERS DISEASE

Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1βAxis in Microglia

(2016) Da-ming Sui et al.   MEDIATORS OF INFLAMMATION

Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation

(2016) Benjamin H. Singer et al.   PLoS One

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

Cognitive decline after sepsis

(2015) Djillali Annane et al.   Lancet Respiratory Medicine

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

Neuropathological processes in sepsis

(2014) Tarek Sharshar et al.   LANCET NEUROLOGY

Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1β: Implications for Cognitive Impairment in Sepsis

(2014) Carolina A. Moraes et al.   MOLECULAR NEUROBIOLOGY

Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats

(2014) Hui Qun Fu et al.   PLoS One

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Connecting Type 2 diabetes to Alzheimer’s disease

(2013) Fernanda G De Felice   Expert Review of Neurotherapeutics

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

Long-Term Cognitive Impairment after Critical Illness

(2013) P.P. Pandharipande et al.   NEW ENGLAND JOURNAL OF MEDICINE

Late brain alterations in sepsis-survivor rats

(2013) Amanda V. Steckert et al.   SYNAPSE

The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors

(2012) Max L. Gunther et al.   CRITICAL CARE MEDICINE

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

(2012) Alexander Semmler et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

(2012) Caitriona M. Long-Smith et al.   NEUROMOLECULAR MEDICINE

Insulin resistance and Alzheimer's disease

(2011) Suzanne M. De La Monte   BMB Reports

Sepsis-Associated Encephalopathy: Review of the Neuropsychiatric Manifestations and Cognitive Outcome

(2011) C. D. Lamar et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

(2011) B. DaRocha-Souto et al.   NEUROBIOLOGY OF DISEASE

GSK3 and Alzheimer’s disease: facts and fiction…

(2011) Anna Kremer   Frontiers in Molecular Neuroscience

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

(2010) Timothy D. Girard et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Liraglutide: once-daily GLP-1 agonist for the treatment of type 2 diabetes

(2010) Gina J. Ryan et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Critical care and the global burden of critical illness in adults

(2010) Neill KJ Adhikari et al.   LANCET

Alterations in Inflammatory Mediators, Oxidative Stress Parameters and Energetic Metabolism in the Brain of Sepsis Survivor Rats

(2010) Clarissa M. Comim et al.   NEUROCHEMICAL RESEARCH

Plastic modifications induced by object recognition memory processing

(2010) J. R. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets

(2009) Sophie E Leney et al.   JOURNAL OF ENDOCRINOLOGY

NOS2 Gene Deficiency Protects from Sepsis-Induced Long-Term Cognitive Deficits

(2009) M. Weberpals et al.   JOURNAL OF NEUROSCIENCE

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

Insulin action on glucose transporters through molecular switches, tracks and tethers

(2008) Hilal Zaid et al.   BIOCHEMICAL JOURNAL