Alzheimer’s disease and insulin resistance: translating basic science into clinical applications
出版年份 2013 全文链接
标题
Alzheimer’s disease and insulin resistance: translating basic science into clinical applications
作者
关键词
-
出版物
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 2, Pages 531-539
出版商
American Society for Clinical Investigation
发表日期
2013-03-18
DOI
10.1172/jci64595
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Oxidative Stress in Diabetes and Alzheimer's Disease
- (2017) V. Prakash Reddy et al. JOURNAL OF ALZHEIMERS DISEASE
- Insulin Levels are Decreased in the Cerebrospinal Fluid of Women with Prodomal Alzheimer's Disease
- (2017) Francisco J. Gil-Bea et al. JOURNAL OF ALZHEIMERS DISEASE
- Hypothalamic inflammation: a double-edged sword to nutritional diseases
- (2012) Dongsheng Cai et al. Annals of the New York Academy of Sciences
- Mechanisms for Insulin Resistance: Common Threads and Missing Links
- (2012) Varman T. Samuel et al. CELL
- Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease
- (2012) Mark P. Mattson Cell Metabolism
- Impaired Insulin Sensitivity as Indexed by the HOMA Score Is Associated With Deficits in Verbal Fluency and Temporal Lobe Gray Matter Volume in the Elderly
- (2012) C. Benedict et al. DIABETES CARE
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology
- (2012) Nicole L Bjorklund et al. Molecular Neurodegeneration
- PRINT - ALZHEIMER’S
- (2012) Meredith Wadman NATURE
- Insulin resistance and AD—extending the translational path
- (2012) Suzanne Craft Nature Reviews Neurology
- The many faces of insulin-like peptide signalling in the brain
- (2012) Ana M. Fernandez et al. NATURE REVIEWS NEUROSCIENCE
- Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity
- (2012) Kendra L. Puig et al. PLoS One
- Preventing Alzheimer's Disease
- (2012) D. J. Selkoe SCIENCE
- Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking
- (2011) Pasquale Picone et al. AGING CELL
- Inflammatory Mechanisms in Obesity
- (2011) Margaret F. Gregor et al. Annual Review of Immunology
- Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment
- (2011) Jennifer L. Bayer-Carter et al. ARCHIVES OF NEUROLOGY
- Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment
- (2011) Suzanne Craft ARCHIVES OF NEUROLOGY
- Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation
- (2011) Ryan G. Holzer et al. CELL
- Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis
- (2011) Thomas Scherer et al. Cell Metabolism
- Cognition and Neuropathology in Aging: Multidimensional Perspectives from the Rush Religious Orders Study and Rush Memory and Aging Project
- (2011) S. Negash et al. Current Alzheimer Research
- Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism
- (2011) V. Ott et al. DIABETES OBESITY & METABOLISM
- Effect of Intranasal Insulin on Cognitive Function: A Systematic Review
- (2011) Elad Shemesh et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid , Novel Targets in Sporadic Alzheimer's Disease
- (2011) H. Geekiyanage et al. JOURNAL OF NEUROSCIENCE
- The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease
- (2011) P. L. McClean et al. JOURNAL OF NEUROSCIENCE
- Alzheimer's disease
- (2011) Clive Ballard et al. LANCET
- National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
- (2011) Goodarz Danaei et al. LANCET
- Insulin receptor substrate 2 is a negative regulator of memory formation
- (2011) E. E. Irvine et al. LEARNING & MEMORY
- Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions
- (2011) Helgi B. Schiöth et al. MOLECULAR NEUROBIOLOGY
- Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
- (2011) Suneng Fu et al. NATURE
- Linking lipids to Alzheimer's disease: cholesterol and beyond
- (2011) Gilbert Di Paolo et al. NATURE REVIEWS NEUROSCIENCE
- The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
- (2011) Sergio T. Ferreira et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF
- (2010) Andrea C. Paula-Lima et al. ANTIOXIDANTS & REDOX SIGNALING
- Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
- (2010) Takahisa Nakamura et al. CELL
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
- (2010) Gökhan S. Hotamisligil CELL
- Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors
- (2010) Elena Alberdi et al. CELL CALCIUM
- Increased Brain Fatty Acid Uptake in Metabolic Syndrome
- (2010) A. Karmi et al. DIABETES
- Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men
- (2010) C. Benedict et al. DIABETES
- Inhaled Insulin Forms Toxic Pulmonary Amyloid Aggregates
- (2010) Cristian A. Lasagna-Reeves et al. ENDOCRINOLOGY
- High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
- (2010) Hiroaki Fukumoto et al. FASEB JOURNAL
- Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-β Oligomers
- (2010) Sofia Jürgensen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers
- (2010) Helena Decker et al. JOURNAL OF NEUROCHEMISTRY
- Reimagining Alzheimer's Disease--An Age-Based Hypothesis
- (2010) K. Herrup JOURNAL OF NEUROSCIENCE
- A Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines
- (2010) H. Zempel et al. JOURNAL OF NEUROSCIENCE
- Differential Effects of Injury Severity on Cognition and Cellular Pathology after Contusive Brain Trauma in the Immature Rat
- (2010) Jimmy W. Huh et al. JOURNAL OF NEUROTRAUMA
- Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress
- (2010) K N Manolopoulos et al. MOLECULAR PSYCHIATRY
- Microglia in neurodegenerative disease
- (2010) V. Hugh Perry et al. Nature Reviews Neurology
- The Genetics of Alzheimer Disease: Back to the Future
- (2010) Lars Bertram et al. NEURON
- Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria
- (2010) Leonardo M. Saraiva et al. PLoS One
- Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A deposition in an Alzheimer mouse model with diabetes
- (2010) S. Takeda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin signaling meets mitochondria in metabolism
- (2010) Zhiyong Cheng et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
- (2009) Jeroen J.M. Hoozemans et al. AMERICAN JOURNAL OF PATHOLOGY
- Feed-forward signaling of TNF-α and NF-κB via IKK-β pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice
- (2009) Jiyeon Yang et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A Specific Enzyme-Linked Immunosorbent Assay for Measuring β-Amyloid Protein Oligomers in Human Plasma and Brain Tissue of Patients With Alzheimer Disease
- (2009) Weiming Xia et al. ARCHIVES OF NEUROLOGY
- The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia
- (2009) Suzanne Craft ARCHIVES OF NEUROLOGY
- Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats.
- (2009) V. Haj-ali et al. BEHAVIORAL NEUROSCIENCE
- Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
- (2009) Talib Abbas et al. BEHAVIOURAL BRAIN RESEARCH
- Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
- (2009) Richard Killick et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease
- (2009) Susanna Freude et al. FASEB JOURNAL
- -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin
- (2009) Q.-L. Ma et al. JOURNAL OF NEUROSCIENCE
- In vivo electrophysiological effects of insulin in the rat brain
- (2009) Peter Kovacs et al. NEUROPEPTIDES
- Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
- (2009) Fernanda G. De Felice et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid- Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
- (2009) J.-E. Kang et al. SCIENCE
- Phosphorylation of IRS proteins, insulin action, and insulin resistance
- (2008) Sigalit Boura-Halfon et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
- (2008) Leah R Hanson et al. BMC NEUROSCIENCE
- Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
- (2008) Xiaoqing Zhang et al. CELL
- Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair
- (2008) Thomas. J. Nelson et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
- (2008) Alexis M. Stranahan et al. HIPPOCAMPUS
- Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin
- (2008) Christian Benedict et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
- (2008) Aileen M. Moloney et al. NEUROBIOLOGY OF AGING
- Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo
- (2008) Shu-Ling Chiu et al. NEURON
- Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
- (2008) Tracy O'Connor et al. NEURON
- Slow-wave sleep and the risk of type 2 diabetes in humans
- (2008) E. Tasali et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin-Like Signaling, Nutrient Homeostasis, and Life Span
- (2007) Akiko Taguchi et al. Annual Review of Physiology
- Amyloid beta oligomers induce impairment of neuronal insulin receptors
- (2007) Wei-Qin Zhao et al. FASEB JOURNAL
- Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
- (2007) Fernanda G. De Felice et al. NEUROBIOLOGY OF AGING
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started