Alpha Particle–Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery
出版年份 2023 全文链接
标题
Alpha Particle–Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery
作者
关键词
-
出版物
MOLECULAR IMAGING AND BIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2023-10-17
DOI
10.1007/s11307-023-01857-y
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cancer statistics, 2023
- (2023) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Evaluation of Candidate Theranostics for227Th/89Zr Paired Radioimmunotherapy of Lymphoma
- (2023) Diane S. Abou et al. JOURNAL OF NUCLEAR MEDICINE
- Optimized production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair for nuclear medicine
- (2023) Brooke L. McNeil et al. Scientific Reports
- Production of pilot batches 223Ra and 227Th of medical purpose
- (2022) P.S. Butkalyuk et al. APPLIED RADIATION AND ISOTOPES
- In vitro dose effect relationships of actinium-225- and lutetium-177-labeled PSMA-I&T
- (2022) Eline A. M. Ruigrok et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Targeted radionuclide therapy with low and high-dose Lutetium-177 labeled single domain antibodies induces distinct immune signatures in a mouse melanoma model
- (2022) Thomas Ertveldt et al. MOLECULAR CANCER THERAPEUTICS
- Lutetium Lu 177 Vipivotide Tetraxetan: First Approval
- (2022) Susan J. Keam Molecular Diagnosis & Therapy
- Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy
- (2022) Toshiaki Nakano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe
- (2022) G. W. Severin et al. Scientific Reports
- Upregulation of PSMA Expression by Enzalutamide in Patients with Advanced mCRPC
- (2022) Florian Rosar et al. Cancers
- Recent advances in microfluidic devices for radiosynthesis of PET‐imaging probes
- (2022) Husamelden Elkawad et al. Chemistry-An Asian Journal
- Evaluation of 134Ce as a PET imaging surrogate for antibody drug conjugates incorporating 225Ac
- (2022) Tyler A. Bailey et al. NUCLEAR MEDICINE AND BIOLOGY
- Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity
- (2022) Bartosz Wiernicki et al. Nature Communications
- Cross-reactivity to glutamate carboxypeptidase III causes undesired salivary gland and kidney uptake of PSMA-targeted small-molecule radionuclide therapeutics
- (2022) Laura Lucaroni et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Radionuclides for Targeted Therapy: Physical Properties
- (2022) Caroline Stokke et al. MOLECULES
- Is early-onset cancer an emerging global epidemic? Current evidence and future implications
- (2022) Tomotaka Ugai et al. Nature Reviews Clinical Oncology
- An alternative radiochemical separation strategy for isolation of Ac and Ra isotopes from high energy proton irradiated thorium targets for further application in Targeted Alpha Therapy (TAT)
- (2022) Ayagoz Baimukhanova et al. NUCLEAR MEDICINE AND BIOLOGY
- Production of [11C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer
- (2022) Hemantha Mallapura et al. MOLECULES
- First-in-Human Application of Terbium-161: A Feasibility Study Using 161Tb-DOTATOC
- (2021) Richard P. Baum et al. JOURNAL OF NUCLEAR MEDICINE
- Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry
- (2021) Daniel F. Earley et al. MOLECULES
- Anti-Tumor Efficacy of PD-L1 Targeted Alpha-Particle Therapy in a Human Melanoma Xenograft Model
- (2021) Marisa Capitao et al. Cancers
- Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective
- (2021) Xi-min Hu et al. Frontiers in Cell and Developmental Biology
- Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
- (2021) Guang Lei et al. ONCOGENE
- Preparation and Preliminary Evaluation of Neurotensin Radiolabelled with 68Ga and 177Lu as Potential Theranostic Agent for Colon Cancer
- (2021) Radu Anton Leonte et al. Pharmaceutics
- Development of [225Ac]Ac-PSMA-I&T for Targeted Alpha Therapy According to GMP Guidelines for Treatment of mCRPC
- (2021) Eline L. Hooijman et al. Pharmaceutics
- Simultaneous Visualization of 161Tb- and 177Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging
- (2021) Francesca Borgna et al. Pharmaceutics
- Cyclotron production of 225Ac from an electroplated 226Ra target
- (2021) Kotaro Nagatsu et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- An improved 211At-labeled agent for PSMA-targeted alpha therapy
- (2021) Ronnie C Mease et al. JOURNAL OF NUCLEAR MEDICINE
- Lutetium-177–prostate-specific membrane antigen ligand following radium-223 treatment in men with bone-metastatic castration-resistant prostate cancer: real-world clinical experience
- (2021) Alton O Sartor et al. JOURNAL OF NUCLEAR MEDICINE
- First in vivo and phantom imaging of cyclotron produced 133La as a theranostic radionuclide for 225Ac and 135La
- (2021) Bryce Nelson et al. JOURNAL OF NUCLEAR MEDICINE
- High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells
- (2021) Tiara Bunga Mayang Permata et al. JOURNAL OF RADIATION RESEARCH
- 68Ga- and 211At-Labeled RGD Peptides for Radiotheranostics with Multiradionuclides
- (2021) Kazuma Ogawa et al. MOLECULAR PHARMACEUTICS
- Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer
- (2021) Oliver Sartor et al. NEW ENGLAND JOURNAL OF MEDICINE
- The salivary glands as a dose limiting organ of PSMA- targeted radionuclide therapy: A review of the lessons learnt so far
- (2021) Nathalie Heynickx et al. NUCLEAR MEDICINE AND BIOLOGY
- Production, purification and availability of 211At: Near term steps towards global access
- (2021) Yutian Feng et al. NUCLEAR MEDICINE AND BIOLOGY
- Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade
- (2021) Ravi B. Patel et al. Science Translational Medicine
- Dosimetric impact of Ac-227 in accelerator-produced Ac-225 for alpha-emitter radiopharmaceutical therapy of patients with hematological malignancies: a pharmacokinetic modeling analysis
- (2021) George Sgouros et al. EJNMMI Physics
- CERN-MEDICIS: A Review Since Commissioning in 2017
- (2021) Charlotte Duchemin et al. Frontiers in Medicine
- An Unusual Pair: Facile Formation and In Vivo Validation of Robust Sc– 18 F Ternary Complexes for Molecular Imaging
- (2021) Jennifer N. Whetter et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A heavy-ion production channel of 149Tb via 63Cu bombardment of 89Y
- (2021) John T. Wilkinson et al. APPLIED RADIATION AND ISOTOPES
- Chelating the Alpha Therapy Radionuclides 225Ac3+ and 213Bi3+ with 18-Membered Macrocyclic Ligands Macrodipa and Py-Macrodipa
- (2021) Aohan Hu et al. INORGANIC CHEMISTRY
- Immunogenic ferroptosis and where to find it?
- (2021) Robin Demuynck et al. Journal for ImmunoTherapy of Cancer
- The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
- (2020) Guang Lei et al. CELL RESEARCH
- Prospective Evaluation of Bone Metabolic Markers as Surrogate Markers of Response to Radium-223 Therapy in Metastatic Castration Resistant Prostate Cancer.
- (2020) Neeraj Agarwal et al. CLINICAL CANCER RESEARCH
- Radiotherapy and immunotherapy for cancer: From "systemic" to "multi-site"
- (2020) Ainhoa Arina et al. CLINICAL CANCER RESEARCH
- Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins
- (2020) Adrián Campos et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Preparation of the alpha-emitting prostate-specific membrane antigen targeted radioligand [212 Pb]Pb-NG001 for prostate cancer
- (2020) Vilde Yuli Stenberg et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production
- (2020) A. N. Moiseeva et al. Scientific Reports
- Secretion of acid sphingomyelinase and ceramide by endothelial cells contributes to radiation-induced intestinal toxicity
- (2020) Daniela Leonetti et al. CANCER RESEARCH
- Preliminary Evaluation of Astatine-211-Labeled Bombesin Derivatives for Targeted Alpha Therapy
- (2020) Miho Aoki et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- PD31-06 UPDATED LONG-TERM SURVIVAL AND SAFETY FROM A MULTI-CENTER, OPEN-LABEL, PIVOTAL PHASE 2 STUDY OF AZEDRA® IN PATIENTS WITH UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC PHEOCHROMOCYTOMA OR PARAGANGLIOMA
- (2020) Camilo Jimenez* et al. JOURNAL OF UROLOGY
- Preclinical Evaluation of a High-Affinity Sarcophagine-Containing PSMA Ligand for 64Cu/67Cu-Based Theranostics in Prostate Cancer
- (2020) James M. Kelly et al. MOLECULAR PHARMACEUTICS
- Targeting apoptosis in cancer therapy
- (2020) Benedito A. Carneiro et al. Nature Reviews Clinical Oncology
- Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
- (2020) Klaudia Szymonowicz et al. Cells
- Radiation-induced bystander and abscopal effects: important lessons from preclinical models
- (2020) Elisabeth Daguenet et al. BRITISH JOURNAL OF CANCER
- ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways
- (2020) Xu Feng et al. EMBO JOURNAL
- High-Yielding Radiosynthesis of [68Ga]Ga-PSMA-11 Using a Low-Cost Microfluidic Device
- (2020) Xin Zhang et al. MOLECULAR IMAGING AND BIOLOGY
- Therapeutic Efficacy of 213Bi-labeled sdAbs in a Preclinical Model of Ovarian Cancer
- (2020) Yana Dekempeneer et al. MOLECULAR PHARMACEUTICS
- The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors
- (2020) Tordis Johnsen Dahle et al. Physica Medica-European Journal of Medical Physics
- Establishment of a clinical SPECT/CT protocol for imaging of 161Tb
- (2020) I. Marin et al. EJNMMI Physics
- Construction of a thorium/actinium generator at the Canadian Nuclear Laboratories
- (2020) Randy Perron et al. APPLIED RADIATION AND ISOTOPES
- Advancements in the use of Auger electrons in science and medicine during the period 2015–2019
- (2020) Roger W. Howell INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- First clinical results for PSMA targeted alpha therapy using 225Ac-PSMA-I&T in advanced mCRPC patients
- (2020) Mathias Johannes Zacherl et al. JOURNAL OF NUCLEAR MEDICINE
- Evaluation of [225Ac]Ac-DOTA-anti-VLA-4 for targeted alpha therapy of metastatic melanoma
- (2020) Angel Cortez et al. NUCLEAR MEDICINE AND BIOLOGY
- Activity and Adverse Events of Actinium-225-PSMA-617 in Advanced Metastatic Castration-resistant Prostate Cancer After Failure of Lutetium-177-PSMA
- (2020) Benedikt Feuerecker et al. EUROPEAN UROLOGY
- Developing the 134Ce and 134La pair as companion positron emission tomography diagnostic isotopes for 225Ac and 227Th radiotherapeutics
- (2020) Tyler A. Bailey et al. Nature Chemistry
- Nimotuzumab Site-Specifically Labeled with 89Zr and 225Ac Using SpyTag/SpyCatcher for PET Imaging and Alpha Particle Radioimmunotherapy of Epidermal Growth Factor Receptor Positive Cancers
- (2020) Viswas Raja Solomon et al. Cancers
- Development and dosimetry of 203Pb/212Pb-labelled PSMA ligands: bringing “the lead” into PSMA-targeted alpha therapy?
- (2019) José Carlos dos Santos et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Frequency of everyday pro-environmental behaviour is explained by baseline activation in lateral prefrontal cortex
- (2019) Thomas Baumgartner et al. Scientific Reports
- Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2019) Matthew Smith et al. LANCET ONCOLOGY
- Direct and bystander effects in human blood lymphocytes exposed to 241Am alpha particles and the relative biological effectiveness using chromosomal aberration and micronucleus assay
- (2019) K. Karthik et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- 68Ga-PSMA PET/CT for monitoring response to 177Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer
- (2019) Alexander Heinzel et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications
- (2019) Veronika Rosecker et al. CHEMBIOCHEM
- PREDICTORS OF OVERALL AND DISEASE FREE SURVIVAL IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER PATIENTS RECEIVING 225Ac-PSMA-617 RADIOLIGAND THERAPY
- (2019) Mike Sathekge et al. JOURNAL OF NUCLEAR MEDICINE
- Targeting PARP-1 with alpha-particles is potently cytotoxic to human neuroblastoma in pre-clinical models
- (2019) Mehran Makvandi et al. MOLECULAR CANCER THERAPEUTICS
- Correction to: 225Ac-PSMA-617 in chemotherapy-naive patients with advanced prostate cancer: a pilot study
- (2019) Mike Sathekge et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study
- (2019) Caroline Robert et al. LANCET ONCOLOGY
- Labeling of Anti-HER2 Nanobodies with Astatine-211: Optimization and the Effect of Different Coupling Reagents on Their in Vivo Behavior
- (2019) Yana Dekempeneer et al. MOLECULAR PHARMACEUTICS
- DNA double-strand break repair-pathway choice in somatic mammalian cells
- (2019) Ralph Scully et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system
- (2019) Claire Lhuillier et al. Genome Medicine
- 177Lu-labeled low-molecular-weight agents for PSMA-targeted radiopharmaceutical therapy
- (2019) Sangeeta Ray Banerjee et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death
- (2019) Scott J. Bright et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Dose-Dependent Growth Delay of Breast Cancer Xenografts in the Bone Marrow of Mice Treated with Radium-223: The Role of Bystander Effects and their Potential for Therapy
- (2019) Calvin N Leung et al. JOURNAL OF NUCLEAR MEDICINE
- The Current Role of Microfluidics in Radiofluorination Chemistry
- (2019) Karla-Anne Knapp et al. MOLECULAR IMAGING AND BIOLOGY
- 111In and 225Ac-labeled cixutumumab for imaging and alpha particle radiotherapy of IGF-1R positive triple negative breast cancer
- (2019) Viswas Raja Solomon et al. MOLECULAR PHARMACEUTICS
- 225Ac-PSMA-617/177Lu-PSMA-617 tandem therapy of metastatic castration-resistant prostate cancer: pilot experience
- (2019) Fadi Khreish et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Theranostics targeting fibroblast activation protein in the tumor stroma: 64Cu and 225Ac labelled FAPI-04 in pancreatic cancer xenograft mouse models
- (2019) Tadashi Watabe et al. JOURNAL OF NUCLEAR MEDICINE
- PARP-1-targeted Auger emitters display high-LET cytotoxic properties in vitro but show limited therapeutic utility in solid tumor models of human neuroblastoma
- (2019) Hwan Lee et al. JOURNAL OF NUCLEAR MEDICINE
- [68Ga]Ga/[177Lu]Lu-BL01, a Novel Theranostic Pair for Targeting C-X-C Chemokine Receptor 4
- (2019) Joseph Lau et al. MOLECULAR PHARMACEUTICS
- Alpha-PET for Prostate Cancer: Preclinical investigation using 149Tb-PSMA-617
- (2019) Christoph A. Umbricht et al. Scientific Reports
- Toward 18 F‐Labeled Theranostics: A Single Agent that Can Be Labeled with 18 F, 64 Cu, or 177 Lu
- (2019) Mathieu L. Lepage et al. CHEMBIOCHEM
- Preclinical Efficacy of a PSMA-Targeted Thorium-227 Conjugate (PSMA-TTC), a Targeted Alpha Therapy for Prostate Cancer
- (2019) Stefanie Hammer et al. CLINICAL CANCER RESEARCH
- Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis
- (2018) Jean-Pierre Pouget et al. ANTIOXIDANTS & REDOX SIGNALING
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- The Clustered DNA Lesions - Types, Pathways of Repair and Relevance to Human Health
- (2018) Barbara Bukowska et al. CURRENT MEDICINAL CHEMISTRY
- Treatment of carcinoma in situ of the urinary bladder with an alpha-emitter immunoconjugate targeting the epidermal growth factor receptor: a pilot study
- (2018) Michael E. Autenrieth et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Three-year Safety of Radium-223 Dichloride in Patients with Castration-resistant Prostate Cancer and Symptomatic Bone Metastases from Phase 3 Randomized Alpharadin in Symptomatic Prostate Cancer Trial
- (2018) Christopher C. Parker et al. EUROPEAN UROLOGY
- The future impacts of non-targeted effects
- (2018) Scott Bright et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with225Ac-PSMA-617: Swimmer-Plot Analysis Suggests Efficacy Regarding Duration of Tumor Control
- (2018) Clemens Kratochwil et al. JOURNAL OF NUCLEAR MEDICINE
- [ 177 Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study
- (2018) Michael S Hofman et al. LANCET ONCOLOGY
- Evaluation of an Anti-HER2 Nanobody Labeled with 225Ac for Targeted α-Particle Therapy of Cancer
- (2018) Marek Pruszynski et al. MOLECULAR PHARMACEUTICS
- Chromosomal instability drives metastasis through a cytosolic DNA response
- (2018) Samuel F. Bakhoum et al. NATURE
- Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation
- (2018) Jaeyeon Choi et al. NUCLEAR MEDICINE AND BIOLOGY
- Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature
- (2018) Sean W. Reilly et al. ORGANIC LETTERS
- PSMA expression: a potential ally for the pathologist in prostate cancer diagnosis
- (2018) Sara Bravaccini et al. Scientific Reports
- Increase in PD-L1 expression after pre-operative radiotherapy for soft tissue sarcoma
- (2018) Kirtesh R. Patel et al. OncoImmunology
- 225Ac-PSMA-617 in chemotherapy-naive patients with advanced prostate cancer: a pilot study
- (2018) Mike Sathekge et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Solution Thermodynamics and Kinetics of Metal Complexation with a Hydroxypyridinone Chelator Designed for Thorium-227 Targeted Alpha Therapy
- (2018) Gauthier J.-P. Deblonde et al. INORGANIC CHEMISTRY
- Efficacy and Safety of High-Specific-Activity I-131 MIBG Therapy in Patients with Advanced Pheochromocytoma or Paraganglioma
- (2018) Daniel A. Pryma et al. JOURNAL OF NUCLEAR MEDICINE
- Radiotherapy induces responses of lung cancer to CTLA-4 blockade
- (2018) Silvia C. Formenti et al. NATURE MEDICINE
- Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells
- (2018) Julia Krombach et al. OncoImmunology
- Expression of Prostate-Specific Membrane Antigen (PSMA) on Biopsies Is an Independent Risk Stratifier of Prostate Cancer Patients at Time of Initial Diagnosis
- (2018) Marie Christine Hupe et al. Frontiers in Oncology
- Targeted alpha therapy of mCRPC: Dosimetry estimate of 213Bismuth-PSMA-617
- (2017) Clemens Kratochwil et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- 213Bi-PSMA-617 targeted alpha-radionuclide therapy in metastatic castration-resistant prostate cancer
- (2017) Mike Sathekge et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Repeated PSMA-targeting radioligand therapy of metastatic prostate cancer with 131I-MIP-1095
- (2017) Ali Afshar-Oromieh et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Diagnostic performance of 68Ga-PSMA-11 (HBED-CC) PET/CT in patients with recurrent prostate cancer: evaluation in 1007 patients
- (2017) Ali Afshar-Oromieh et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1
- (2017) Erkin Erdal et al. GENES & DEVELOPMENT
- Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy
- (2017) Kareen Bartsch et al. HUMAN MOLECULAR GENETICS
- Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with225Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding
- (2017) Clemens Kratochwil et al. JOURNAL OF NUCLEAR MEDICINE
- The Impact of68Ga-PSMA PET/CT on Management Intent in Prostate Cancer: Results of an Australian Prospective Multicenter Study
- (2017) Paul J. Roach et al. JOURNAL OF NUCLEAR MEDICINE
- Regulation of repair pathway choice at two-ended DNA double-strand breaks
- (2017) Atsushi Shibata MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Mitotic progression following DNA damage enables pattern recognition within micronuclei
- (2017) Shane M. Harding et al. NATURE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- Development of a preclinical 211 Rn/ 211 At generator system for targeted alpha therapy research with 211 At
- (2017) Jason R. Crawford et al. NUCLEAR MEDICINE AND BIOLOGY
- Preparation of 212 Pb-labeled monoclonal antibody using a novel 224 Ra-based generator solution
- (2017) Sara Westrøm et al. NUCLEAR MEDICINE AND BIOLOGY
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exosome-Mediated Telomere Instability in Human Breast Epithelial Cancer Cells after X Irradiation
- (2017) Ammar H. J. Al-Mayah et al. RADIATION RESEARCH
- DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
- (2017) Hiro Sato et al. Nature Communications
- DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
- (2017) Claire Vanpouille-Box et al. Nature Communications
- Radioligand therapy of metastatic prostate cancer using 177Lu-PSMA-617 after radiation exposure to 223Ra-dichloride
- (2017) Hojjat Ahmadzadehfar et al. Oncotarget
- Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates
- (2017) David Teze et al. Scientific Reports
- BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation
- (2017) Mayu Isono et al. Cell Reports
- Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model
- (2017) Jessie R. Nedrow et al. EJNMMI Research
- Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects
- (2016) Salomé Paillas et al. ANTIOXIDANTS & REDOX SIGNALING
- An efficient chelator for complexation of thorium-227
- (2016) Thomas Ramdahl et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy
- (2016) M. Makvandi et al. CANCER RESEARCH
- Zevalin® (ibritumomab tiuxetan): After more than a decade of treatment experience, what have we learned?
- (2016) David Rizzieri CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment
- (2016) Paola Moreno et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Microfluidic Preparation of a 89Zr-Labeled Trastuzumab Single-Patient Dose
- (2016) B. D. Wright et al. JOURNAL OF NUCLEAR MEDICINE
- Response and Tolerability of a Single Dose of 177Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer: A Multicenter Retrospective Analysis
- (2016) K. Rahbar et al. JOURNAL OF NUCLEAR MEDICINE
- 225Ac-PSMA-617 for PSMA-Targeted -Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer
- (2016) C. Kratochwil et al. JOURNAL OF NUCLEAR MEDICINE
- Systemic Radioligand Therapy with 177Lu Labeled Prostate Specific Membrane Antigen Ligand for Imaging and Therapy in Patients with Metastatic Castration Resistant Prostate Cancer
- (2016) Matthias M. Heck et al. JOURNAL OF UROLOGY
- Damage-associated molecular patterns in cancer: a double-edged sword
- (2016) C Hernandez et al. ONCOGENE
- From palliative therapy to prolongation of survival: 223RaCl2 in the treatment of bone metastases
- (2016) Knut Liepe et al. Therapeutic Advances in Medical Oncology
- The Emerging Role of Carbon-Ion Radiotherapy
- (2016) Daniel K. Ebner et al. Frontiers in Oncology
- Nitric Oxide (NO) Mediates the Inhibition of Form-Deprivation Myopia by Atropine in Chicks
- (2016) Brittany J. Carr et al. Scientific Reports
- DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
- (2015) Anetta Härtlova et al. IMMUNITY
- Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer
- (2015) M. Bene ova et al. JOURNAL OF NUCLEAR MEDICINE
- 68Ga- and 177Lu-Labeled PSMA I&T: Optimization of a PSMA-Targeted Theranostic Concept and First Proof-of-Concept Human Studies
- (2015) M. Weineisen et al. JOURNAL OF NUCLEAR MEDICINE
- The non-targeted effects of radiation are perpetuated by exosomes
- (2015) Ammar Al-Mayah et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
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- (2014) Muhammad Zaeem Noman et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2014) M. Pruszynski et al. JOURNAL OF NUCLEAR MEDICINE
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- (2014) C. Muller et al. JOURNAL OF NUCLEAR MEDICINE
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- (2014) L. Antonovic et al. JOURNAL OF RADIATION RESEARCH
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- (2014) Y. Hu et al. Cancer Discovery
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- (2011) D. Wild et al. CANCER RESEARCH
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- (2008) Ning Cao et al. RADIATION RESEARCH
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