Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?

Biological consequences of formation and repair of complex DNA damage

(2012) Karin Magnander et al.   CANCER LETTERS

Oxidatively generated complex DNA damage: Tandem and clustered lesions

(2012) Jean Cadet et al.   CANCER LETTERS

Mechanisms of free radical-induced damage to DNA

(2012) Miral Dizdaroglu et al.   FREE RADICAL RESEARCH

The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions

(2012) Miho Noguchi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages

(2012) R. Greinert et al.   NUCLEIC ACIDS RESEARCH

Interaction of poly(ADP-ribose) polymerase 1 with apurinic/apyrimidinic sites within clustered DNA damage

(2011) M. M. Kutuzov et al.   BIOCHEMISTRY-MOSCOW

Abstract 2287: Tumors induce complex DNA damage in distant proliferative tissuesin vivo

(2011) Christophe E. Redon et al.   CANCER RESEARCH

Repair of DNA damage induced by accelerated heavy ions-A mini review

(2011) Ryuichi Okayasu   INTERNATIONAL JOURNAL OF CANCER

Track structure, radiation quality and initial radiobiological events: Considerations based on the PARTRAC code experience

(2011) Daniele Alloni et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Processing of abasic DNA clusters in hApeI-silenced primary fibroblasts exposed to low doses of X-irradiation

(2011) Prolay Das et al.   JOURNAL OF BIOSCIENCES

The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol η in Response to Oxidative DNA Damage in Human Cells

(2011) Anastasia Zlatanou et al.   MOLECULAR CELL

Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC

(2011) Werner Friedland et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair

(2011) Satyendra K. Singh et al.   NUCLEIC ACIDS RESEARCH

Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy

(2011) K. Aziz et al.   PHARMACOLOGY & THERAPEUTICS

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

(2011) A. Asaithamby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death

(2011) Robert D. Stewart et al.   RADIATION RESEARCH

BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions

(2010) Jessica M. Hair et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Radiation induced DNA DSBs: Contribution from stalled replication forks?

(2010) Jane V. Harper et al.   DNA REPAIR

Abasic sites preferentially form at regions undergoing DNA replication

(2010) Paul D. Chastain et al.   FASEB JOURNAL

DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells

(2010) Prakash Peddi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Delayed repair of radiation induced clustered DNA damage: Friend or foe?

(2010) Laura J. Eccles et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival

(2010) Evelyne Sage et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Tumors induce complex DNA damage in distant proliferative tissues in vivo

(2010) C. E. Redon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HObullet radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases

(2010) F. Bergeron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustered DNA Damage in Irradiated Human Diploid Fibroblasts: Influence of Chromatin Organization

(2010) Karin Magnander et al.   RADIATION RESEARCH

A Monte Carlo Study of the Radiation Quality Dependence of DNA Fragmentation Spectra

(2010) D. Alloni et al.   RADIATION RESEARCH

Base Damage Immediately Upstream from Double-Strand Break Ends is a More Severe Impediment to Nonhomologous End Joining than Blocked 3′-Termini

(2010) Kamal Datta et al.   RADIATION RESEARCH

Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli

(2009) Naoya Shikazono et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells

(2009) Stanislav G. Kozmin et al.   NUCLEIC ACIDS RESEARCH

Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells

(2009) Xiangduo Kong et al.   NUCLEIC ACIDS RESEARCH

Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic

(2009) Sophie Bellon et al.   NUCLEIC ACIDS RESEARCH

5,6-Dihydrothymine Impairs the Base Excision Repair Pathway of a Closely Opposed AP Site or Single-Strand Break

(2009) Shaun Byrne et al.   RADIATION RESEARCH

NMR Solution Structures of Bistranded Abasic Site Lesions in DNA†‡

(2008) Raphael D. Hazel et al.   BIOCHEMISTRY

Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency

(2008) Prakash Peddi et al.   CANCER LETTERS

PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro

(2008) M TOULANY et al.   DNA REPAIR

Formation of Clustered DNA Damage after High-LET Irradiation: A Review

(2008) Megumi HADA et al.   JOURNAL OF RADIATION RESEARCH

Clustered DNA lesion sites as a source of mutations during human colorectal tumourigenesis

(2008) Ian R. Radford et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells

(2008) Stewart M. Holt et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining

(2008) S. Malyarchuk et al.   NUCLEIC ACIDS RESEARCH

Human abasic endonuclease action on multilesion abasic clusters: implications for radiation-induced biological damage

(2008) B. Paap et al.   NUCLEIC ACIDS RESEARCH

Processing of DNA damage clusters in human cells: current status of knowledge

(2007) Alexandros G. Georgakilas   Molecular BioSystems