Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD

SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

(2023) Teresa Villanueva-Carmona et al.   Cell Metabolism

Inhibition of carnitine palmitoyl-transferase 1A in hepatic stellate cells protects against fibrosis

(2022) Marcos F. Fondevila et al.   JOURNAL OF HEPATOLOGY

Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis

(2022) Yuan-yuan Hao et al.   PHARMACEUTICAL BIOLOGY

Nonalcoholic fatty liver disease shows significant sex dimorphism

(2022) Xing-Yu Chen et al.   World Journal of Clinical Cases

Nanotechnology in Drug Delivery for Liver Fibrosis

(2022) Lihong Gu et al.   Frontiers in Molecular Biosciences

Heterogeneity of non-alcoholic fatty liver disease (NAFLD): Implication for cardiovascular risk stratification

(2022) Francesco Baratta et al.   ATHEROSCLEROSIS

Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH

(2021) Jorge Simón et al.   JOURNAL OF HEPATOLOGY

The mitochondrial dicarboxylate carrier prevents hepatic lipotoxicity by inhibiting white adipocyte lipolysis

(2021) Yu A. An et al.   JOURNAL OF HEPATOLOGY

Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults

(2021) Francisco J. Osuna-Prieto et al.   Cardiovascular Diabetology

Western Diet Decreases the Liver Mitochondrial Oxidative Flux of Succinate: Insight from a Murine NAFLD Model

(2021) Pavla Staňková et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

(2021) Daniel Ferguson et al.   Nature Reviews Endocrinology

Rethinking succinate: an unexpected hormone-like metabolite in energy homeostasis

(2021) Sonia Fernández-Veledo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endogenous Interleukin-33 Acts as an Alarmin in Liver Ischemia-Reperfusion and Is Associated With Injury After Human Liver Transplantation

(2021) Louise Barbier et al.   Frontiers in Immunology

Succinate‐GPR‐91 receptor signalling is responsible for nonalcoholic steatohepatitis‐associated fibrosis: Effects of DHA supplementation

(2020) Xue‐Jing Liu et al.   LIVER INTERNATIONAL

Mitochondrial DNA from hepatocytes induces upregulation of interleukin-33 expression of macrophages in nonalcoholic steatohepatitis

(2020) Yinjie Gao et al.   DIGESTIVE AND LIVER DISEASE

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

(2020) Ping An et al.   Nature Communications

GPR91 antagonist and TGF-β inhibitor suppressed collagen production of high glucose and succinate induced HSC activation

(2020) Mutsuko Sakai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation

(2020) Grzegorz Krzak et al.   TRENDS IN IMMUNOLOGY

Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis

(2019) Ahlam Khamaysi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

(2019) Noelia Keiran et al.   NATURE IMMUNOLOGY

Succinate induces skeletal muscle fiber remodeling via SUNCR 1 signaling pathway

(2019) Tao Wang et al.   EMBO REPORTS

Preoperative Circulating Succinate Levels as a Biomarker for Diabetes Remission After Bariatric Surgery

(2019) Victoria Ceperuelo-Mallafré et al.   DIABETES CARE

Metabolomic Biomarkers in the Diagnosis of Non-Alcoholic Fatty Liver Disease

(2019) Saeed Chashmniam et al.   Hepatitis Monthly

Non-alcoholic fatty liver disease in adults: Current concepts in etiology, outcomes and management

(2019) Thomas Marjot et al.   ENDOCRINE REVIEWS

Structural basis of species-selective antagonist binding to the succinate receptor

(2019) Matthias Haffke et al.   NATURE

Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition

(2018) Giang Nguyen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate induces hepatic fibrogenesis by promoting activation, proliferation, and migration, and inhibiting apoptosis of hepatic stellate cells

(2018) So Young Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

(2018) Varman T. Samuel et al.   Cell Metabolism

Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota

(2018) Carolina Serena et al.   ISME Journal

LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice

(2018) Cong Thuc Le et al.   PLoS One

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

(2018) Mohammad Zarei et al.   Molecular Metabolism

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

(2018) Zobair M. Younossi et al.   TRANSPLANTATION

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development

(2017) Kun He et al.   Oncotarget

New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2017) Xu Zhang et al.   Protein & Cell

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

(2017) Mette Trauelsen et al.   Molecular Metabolism

Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells

(2016) Ying Hui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis

(2016) Yinjie Gao et al.   Oncotarget

Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells

(2015) Ying Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression and localization of GPR91 and GPR99 in murine organs

(2015) Julia Diehl et al.   CELL AND TISSUE RESEARCH

Metabolic Crosstalk: Molecular Links Between Glycogen and Lipid Metabolism in Obesity

(2014) B. Lu et al.   DIABETES

Targeted Disruption of theSUCNR1Metabolic Receptor Leads to Dichotomous Effects on Obesity

(2014) Kenneth J. McCreath et al.   DIABETES

Pathological Features of Fatty Liver Disease

(2014) Matthew M. Yeh et al.   GASTROENTEROLOGY

The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis

(2013) Diane DeZwaan-McCabe et al.   PLoS Genetics

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPKPathways

(2010) Dan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release

(2009) S. L. Vargas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL