Heterogeneity of non-alcoholic fatty liver disease (NAFLD): Implication for cardiovascular risk stratification

American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings

(2022) Kenneth Cusi et al.   Endocrine Practice

Fibrotic Burden Determines Cardiovascular Risk among Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease

(2022) Eugene Han et al.   Gut and Liver

The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway

(2022) Simone Bini et al.   Biomolecules

The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?

(2021) Simone Bini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elevated Serum Concentrations of Remnant Cholesterol Associate with Increased Carotid Intima-Media Thickness in Children and Adolescents

(2021) Alessia Di Costanzo et al.   JOURNAL OF PEDIATRICS

Glucagon-Like Peptide-1 Receptor Agonists for Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: An Updated Meta-Analysis of Randomized Controlled Trials

(2021) Alessandro Mantovani et al.   Metabolites

Atherogenic dyslipidemia, but not hyperglycemia, is an independent factor associated with liver fibrosis in subjects with type 2 diabetes and NAFLD: A population –based study

(2021) María Teresa Julián et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

(2021) Ramy Younes et al.   GUT

Visceral Adipose Tissue and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

(2021) Sohrab Nobarani et al.   DIGESTIVE DISEASES AND SCIENCES

Metabolic-associated fatty liver disease and lipoprotein metabolism

(2021) Joerg Heeren et al.   Molecular Metabolism

Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity

(2021) Marco Arrese et al.   SEMINARS IN LIVER DISEASE

The challenge of cardiovascular prevention in NAFLD

(2021) Maria Del Ben et al.   Lancet Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis

(2021) Alessandro Mantovani et al.   Lancet Gastroenterology & Hepatology

Inflammatory Mechanisms Contributing to Endothelial Dysfunction

(2021) Panagiotis Theofilis et al.   Biomedicines

Toll-like receptor 4 activation in platelets from myocardial infarction patients

(2021) Francesco Barillà et al.   THROMBOSIS RESEARCH

Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease

(2020) Stefano Romeo et al.   Cell Metabolism

Independent and joint correlation of PNPLA3 I148M and TM6SF2 E167K variants with the risk of coronary heart disease in patients with non-alcoholic fatty liver disease

(2020) Jian-Ting Wu et al.   Lipids in Health and Disease

Triglycerides and remnant cholesterol associated with risk of aortic valve stenosis: Mendelian randomization in the Copenhagen General Population Study

(2020) Morten Kaltoft et al.   EUROPEAN HEART JOURNAL

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis

(2020) Constantinos A. Parisinos et al.   JOURNAL OF HEPATOLOGY

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans

(2020) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

A Systematic Review of Newer Antidiabetic Agents in the Treatment of Nonalcoholic Fatty Liver Disease

(2020) John A. Dougherty et al.   ANNALS OF PHARMACOTHERAPY

Nonalcoholic Steatohepatitis Is the Most Rapidly Increasing Indication for Liver Transplantation in the United States

(2020) Zobair M. Younossi et al.   Clinical Gastroenterology and Hepatology

NAFLD and cardiovascular diseases: a clinical review

(2020) Philipp Kasper et al.   Clinical Research in Cardiology

Trimethylamine N-Oxide levels are associated with NASH in obese subjects with type 2 diabetes

(2020) Paola León-Mimila et al.   DIABETES & METABOLISM

TMAO as a biomarker of cardiovascular events: a systematic review and meta-analysis

(2020) Luigina Guasti et al.   Internal and Emergency Medicine

Prognostic utility of triglyceride-rich lipoproteins-related markers in patients with coronary artery disease

(2020) Ye-Xuan Cao et al.   JOURNAL OF LIPID RESEARCH

Gut microbiota in human metabolic health and disease

(2020) Yong Fan et al.   NATURE REVIEWS MICROBIOLOGY

Long-Term Risk of Major Adverse Cardiac Events in Atrial Fibrillation Patients on Direct Oral Anticoagulants

(2020) Daniele Pastori et al.   MAYO CLINIC PROCEEDINGS

HDL-Mediated Cholesterol Efflux and Plasma Loading Capacities Are Altered in Subjects with Metabolically- but Not Genetically Driven Non-Alcoholic Fatty Liver Disease (NAFLD)

(2020) Alessia Di Costanzo et al.   Biomedicines

Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity

(2019) Alessia Di Costanzo et al.   PEDIATRIC RESEARCH

Nonalcoholic Fatty Liver Disease and the Heart

(2019) Eric P. Stahl et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease

(2019) Cheng-Maw Ho et al.   Journal of Inflammation-London

Trimethylamine N ‐Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease

(2019) Xuying Tan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

(2019) Stefania Grimaudo et al.   Clinical Gastroenterology and Hepatology

Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality

(2019) Martijn C. G. J. Brouwers et al.   DIABETOLOGIA

Increased liver localization of lipopolysaccharides in human and experimental non‐alcoholic fatty liver disease

(2019) Guido Carpino et al.   HEPATOLOGY

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum Angiopoietin-like peptide 4 levels in patients with hepatic steatosis

(2018) Özgür Altun et al.   CYTOKINE

Synergistic increase in cardiovascular risk in diabetes mellitus with nonalcoholic fatty liver disease

(2018) Yao-Yao Zhou et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of dark chocolate on endothelial function in patients with non-alcoholic steatohepatitis

(2018) L. Loffredo et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study

(2018) Jun Morinaga et al.   PLoS One

Localization of lipopolysaccharide from Escherichia Coli into human atherosclerotic plaque

(2018) Roberto Carnevale et al.   Scientific Reports

Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy

(2018) Alessia Di Costanzo et al.   Scientific Reports

PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases

(2018) Jie Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes: A meta-analysis with bias analysis

(2018) Amy E. Morrison et al.   LIVER INTERNATIONAL

Remnant Lipoprotein Cholesterol and Cardiovascular and Cerebrovascular Events in Patients with Non-Alcoholic Fatty Liver Disease

(2018) Daniele Pastori et al.   Journal of Clinical Medicine

Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals

(2017) Bo Kobberø Lauridsen et al.   EUROPEAN HEART JOURNAL

PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease

(2017) Nynke Simons et al.   GASTROENTEROLOGY

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

(2017) P. Dongiovanni et al.   JOURNAL OF INTERNAL MEDICINE

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

(2017) Stefan Stender et al.   NATURE GENETICS

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

PNPLA3 variant and portal/periportal histological pattern in patients with biopsy-proven non-alcoholic fatty liver disease: a possible role for oxidative stress

(2017) Guido Carpino et al.   Scientific Reports

Non-alcoholic fatty liver disease fibrosis score and preclinical vascular damage in morbidly obese patients

(2016) Alessandra Gentili et al.   DIGESTIVE AND LIVER DISEASE

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Hepatic Steatosis and Insulin Resistance, But Not Steatohepatitis, Promote Atherogenic Dyslipidemia in NAFLD

(2016) Fernando Bril et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis

(2016) Giovanni Targher et al.   JOURNAL OF HEPATOLOGY

Combined effects of thePNPLA3rs738409,TM6SF2rs58542926, andMBOAT7rs641738 variants on NAFLD severity: a multicenter biopsy-based study

(2016) Marcin Krawczyk et al.   JOURNAL OF LIPID RESEARCH

Relation of Nonalcoholic Fatty Liver Disease and Framingham Risk Score to Flow-Mediated Dilation in Patients With Cardiometabolic Risk Factors

(2015) Daniele Pastori et al.   AMERICAN JOURNAL OF CARDIOLOGY

Severity of Nonalcoholic Fatty Liver Disease and Progression to Cirrhosis Are Associated With Atherogenic Lipoprotein Profile

(2015) Mohammad S. Siddiqui et al.   Clinical Gastroenterology and Hepatology

Glucokinase regulatory protein

(2015) Anne Raimondo et al.   CURRENT OPINION IN LIPIDOLOGY

The dual and opposite role of theTM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis

(2015) Carlos J. Pirola et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PNPLA3polymorphisms (rs738409) and non-alcoholic fatty liver disease risk and related phenotypes: a meta-analysis

(2015) Long Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development – a potential therapeutic target?

(2015) Paola Dongiovanni et al.   Expert Review of Gastroenterology & Hepatology

Similar Reduction of Cholesterol-Adjusted Vitamin E Serum Levels in Simple Steatosis and Non-Alcoholic Steatohepatitis

(2015) Daniele Pastori et al.   Clinical and Translational Gastroenterology

The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis

(2014) Amit G Singal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

NOX2-generated oxidative stress is associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease

(2014) Maria Del Ben et al.   BMC GASTROENTEROLOGY

Postprandial lipemia as a cardiometabolic risk factor

(2014) Angela Pirillo et al.   CURRENT MEDICAL RESEARCH AND OPINION

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

(2014) Y.-L. Liu et al.   JOURNAL OF HEPATOLOGY

The rs738409 (I148M) variant of thePNPLA3gene and cirrhosis: a meta-analysis

(2014) Jian-Hua Shen et al.   JOURNAL OF LIPID RESEARCH

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

(2014) Oddgeir L Holmen et al.   NATURE GENETICS

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Reduced Atherosclerotic Burden in Subjects With Genetically Determined Low Oxidative Stress

(2013) Francesco Violi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nonalcoholic Fatty Liver Disease: A Novel Cardiometabolic Risk Factor for Type 2 Diabetes and Its Complications

(2013) Giovanni Targher et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

From NAFLD in clinical practice to answers from guidelines

(2013) Fabio Nascimbeni et al.   JOURNAL OF HEPATOLOGY

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease

(2013) Salvatore Petta et al.   PLoS One

Relationship Between Aspartate Aminotransferase-to-Platelet Ratio Index and Carotid Intima-Media Thickness in Obese Adolescents with Non-Alcoholic Fatty Liver Disease

(2013) Sert Ahmet et al.   Journal of Clinical Research in Pediatric Endocrinology

Safety and impact on cardiovascular events of long-term multifactorial treatment in patients with metabolic syndrome and abnormal liver function tests: a post hoc analysis of the randomised ATTEMPT study

(2012) Vassilios G. Athyros et al.   Archives of Medical Science

PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals

(2012) Maria Antonella Burza et al.   DIGESTIVE AND LIVER DISEASE

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Nonalcoholic Fatty Liver Disease in Lean Individuals in the United States

(2012) Zobair M. Younossi et al.   MEDICINE

Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease

(2011) S. Petta et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study

(2011) R. M. Williamson et al.   DIABETES CARE

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

(2010) Elizabeth K. Speliotes et al.   HEPATOLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

(2010) João-Bruno Soares et al.   Hepatology International

Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: Non-invasive elastography-based study in chronic liver disease

(2010) Marcin Krawczyk et al.   JOURNAL OF HEPATOLOGY

Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

(2010) Vasilios G Athyros et al.   LANCET

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Fatty liver, insulin resistance, and dyslipidemia

(2008) Martin Adiels et al.   Current Diabetes Reports

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease

(2008) Janus P. Ong et al.   JOURNAL OF HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

NASH Predicts Plasma Inflammatory Biomarkers Independently of Visceral Fat in Men

(2008) Giovanni Targher et al.   Obesity

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA