Statins inhibit blastocyst formation by preventing geranylgeranylation

Transcription factor AP-2  induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage

(2015) Z. Cao et al.   DEVELOPMENT

Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos

(2015) Yoshikazu Hirate et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats

(2015) Anna Guldvang et al.   REPRODUCTIVE TOXICOLOGY

Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst

(2015) Tristan Frum et al.   TRENDS IN GENETICS

Statins and congenital malformations: cohort study

(2015) B. T. Bateman et al.   BMJ-British Medical Journal

Statins and congenital malformations: cohort study

(2015) B. T. Bateman et al.   BMJ-British Medical Journal

Inhibition of RHO–ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst

(2014) Kanako Kono et al.   DEVELOPMENTAL BIOLOGY

Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst

(2014) Teresa Rayon et al.   DEVELOPMENTAL CELL

Targeting Cellular Squalene Synthase, an Enzyme Essential for Cholesterol Biosynthesis, Is a Potential Antiviral Strategy against Hepatitis C Virus

(2014) Kyoko Saito et al.   JOURNAL OF VIROLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

The pharmacology of statins

(2014) Cesare R. Sirtori   PHARMACOLOGICAL RESEARCH

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

(2014) Behzad Yeganeh et al.   PHARMACOLOGY & THERAPEUTICS

Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies

(2014) Shahram Eisa-Beygi et al.   REPRODUCTIVE TOXICOLOGY

Squalene Synthase As a Target for Chagas Disease Therapeutics

(2014) Na Shang et al.   PLoS Pathogens

Human isoprenoid synthase enzymes as therapeutic targets

(2014) Jaeok Park et al.   Frontiers in Chemistry

Shifts in Intended and Unintended Pregnancies in the United States, 2001–2008

(2013) Lawrence B. Finer et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Rho-Associated Kinase Activity Is Required for Proper Morphogenesis of the Inner Cell Mass in the Mouse Blastocyst1

(2013) Arlene May A. Laeno et al.   BIOLOGY OF REPRODUCTION

Targeting GGTase-I Activates RHOA, Increases Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in Mice

(2013) Omar M. Khan et al.   CIRCULATION

The Hippo Pathway Member Nf2 Is Required for Inner Cell Mass Specification

(2013) Katie Cockburn et al.   CURRENT BIOLOGY

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

(2013) Yoshikazu Hirate et al.   CURRENT BIOLOGY

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

(2013) Liying Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms

(2013) Chuen Yan Leung et al.   Nature Communications

Teratogenic Risk of Statins in Pregnancy

(2012) Laura M Godfrey et al.   ANNALS OF PHARMACOTHERAPY

Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain

(2012) Christian Riebeling et al.   CRITICAL REVIEWS IN TOXICOLOGY

Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis

(2012) Hirotaka Tao et al.   DEVELOPMENTAL BIOLOGY

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse

(2012) Kathy K. Niakan et al.   DEVELOPMENTAL BIOLOGY

Human hypoblast formation is not dependent on FGF signalling

(2011) Mila Roode et al.   DEVELOPMENTAL BIOLOGY

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

(2011) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell Polarity Regulator PARD6B Is Essential for Trophectoderm Formation in the Preimplantation Mouse Embryo1

(2010) Vernadeth B. Alarcon   BIOLOGY OF REPRODUCTION

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2

(2010) A. Ralston et al.   DEVELOPMENT

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Making the blastocyst: lessons from the mouse

(2010) Katie Cockburn et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage

(2010) Connie C Wong et al.   NATURE BIOTECHNOLOGY

Pharmacologic Inhibition of Squalene Synthase and Other Downstream Enzymes of the Cholesterol Synthesis Pathway

(2009) Stephanie Seiki et al.   Cardiology in Review

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL