ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides

Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

(2023) Alexander Waclawiczek et al.   Cancer Discovery

A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy

(2023) Shanshan Pei et al.   Cancer Discovery

Associating Drug Sensitivity with Differentiation Status Identifies Effective Combinations for Acute Myeloid Leukemia

(2022) Stephen E Kurtz et al.   Blood Advances

Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

(2022) Daniel Bottomly et al.   CANCER CELL

Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn

(2022) Jue Zhang et al.   iScience

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

(2022) Heikki Kuusanmäki et al.   BLOOD

Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis

(2021) Antoni Olona et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML

(2021) Maximilian Stahl et al.   Blood Advances

The Past, Present and Future of Venetoclax Plus Hypomethylating Agent Combination Therapies in AML

(2021) Anagha Inguva et al.   Clinical Lymphoma Myeloma & Leukemia

Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia

(2021) Brian S. White et al.   npj Precision Oncology

Quantitative Proteomics of the Cancer Cell Line Encyclopedia

(2020) David P. Nusinow et al.   CELL

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Acute Myeloid Leukemia Patients

(2020) Shanshan Pei et al.   Cancer Discovery

Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

(2020) Shruti Bhatt et al.   CANCER CELL

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

(2019) Peter van Galen et al.   CELL

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

(2019) Heikki Kuusanmäki et al.   HAEMATOLOGICA

Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers

(2019) Dhanasekhar Reddy et al.   LIFE SCIENCES

Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death

(2018) Naira F. Z. Schneider et al.   Frontiers in Pharmacology

Hydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: Involvement of ER stress and DAMP release

(2018) Aloran Mazumder et al.   CANCER LETTERS

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

(2018) Marion Orsini et al.   CELL DEATH AND DIFFERENTIATION

Clinical evaluation of P-glycoprotein inhibition by venetoclax: a drug interaction study with digoxin

(2017) Manoj S. Chiney et al.   XENOBIOTICA

Koi Fish-Scale Iridophore Cells Orient Guanine Crystals to Maximize Light Reflection

(2017) Nir Funt et al.   ChemPlusChem

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

(2017) Luiz H. A. Cavalcante-Silva et al.   Frontiers in Physiology

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

(2016) T.-C. Ho et al.   BLOOD

Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia

(2016) C Cerella et al.   LEUKEMIA

Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia

(2016) S. S. Y. Lam et al.   Science Translational Medicine

Monocytes and macrophages in flow: an ESCCA initiative on advanced analyses of monocyte lineage using flow cytometry

(2015) Claude Lambert et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma

(2015) F Radogna et al.   ONCOGENE

Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

(2015) Mette Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

(2015) C Cerella et al.   Cell Death & Disease

IFN Priming Is Necessary but Not Sufficient To Turn on a Migratory Dendritic Cell Program in Lupus Monocytes

(2014) A. Rodriguez-Pla et al.   JOURNAL OF IMMUNOLOGY

A gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes

(2014) Hubert Hackl et al.   LEUKEMIA & LYMPHOMA

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α

(2013) Ji Cao et al.   BIOCHEMICAL PHARMACOLOGY

Identification of a 24-Gene Prognostic Signature That Improves the European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: An International Collaborative Study

(2013) Zejuan Li et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site

(2013) M. Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency

(2012) Guo Wei et al.   CANCER CELL

Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

(2012) Claudia Cerella et al.   MITOCHONDRION

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Interaction of Digitalis-Like Compounds with P-Glycoprotein

(2012) Elnaz Gozalpour et al.   TOXICOLOGICAL SCIENCES

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

(2010) Tom Juncker et al.   BIOCHEMICAL PHARMACOLOGY

Cardiac glycosides are potent inhibitors of interferon-β gene expression

(2010) Junqiang Ye et al.   Nature Chemical Biology

Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

(2009) Andrea Perne et al.   PLoS One

An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia

(2008) K. H. Metzeler et al.   BLOOD