Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia

BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells

(2016) Michael Butterworth et al.   BRITISH JOURNAL OF CANCER

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise

(2016) Kristopher A. Sarosiek et al.   FEBS Journal

Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

(2016) Giampaolo Morciano et al.   MOLECULAR BIOLOGY OF THE CELL

Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy

(2015) Joan Montero et al.   CELL

BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics

(2015) C Touzeau et al.   LEUKEMIA

Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma

(2015) F Radogna et al.   ONCOGENE

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

(2015) C Cerella et al.   Cell Death & Disease

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

(2013) D. Thomas et al.   BLOOD

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

(2013) R. Pan et al.   Cancer Discovery

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

(2011) M. Vogler et al.   BLOOD

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

(2010) Tom Juncker et al.   BIOCHEMICAL PHARMACOLOGY

The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity

(2010) Chi-Ruei Huang et al.   FEBS LETTERS