Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

(2015) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

(2015) Claudia Cerella et al.   CANCER LETTERS

Effects of Natural Products on Mcl-1 Expression and Function

(2015) Florian Muller et al.   CURRENT MEDICINAL CHEMISTRY

Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetraenoic acid

(2015) F. Radogna et al.   MITOCHONDRION

Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure

(2015) Sherin I. Hashem et al.   STEM CELLS

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

(2015) C Cerella et al.   Cell Death & Disease

Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine

(2015) Ljubica Vucicevic et al.   Autophagy

Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells

(2015) Fangfang Lang et al.   PLoS One

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

(2014) Marie Stampe Ostenfeld et al.   Autophagy

From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment

(2014) Claudia Cerella et al.   BIOTECHNOLOGY ADVANCES

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma

(2014) Stefan Salcher et al.   Molecular Cancer

Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines

(2014) Yan Wang et al.   MOLECULAR CARCINOGENESIS

Loss of PINK1 Impairs Stress-Induced Autophagy and Cell Survival

(2014) Dajana Parganlija et al.   PLoS One

Inhibiting Na+/K+ ATPase Can Impair Mitochondrial Energetics and Induce Abnormal Ca2+ Cycling and Automaticity in Guinea Pig Cardiomyocytes

(2014) Qince Li et al.   PLoS One

Inhibition of Autophagic Flux by Salinomycin Results in Anti-Cancer Effect in Hepatocellular Carcinoma Cells

(2014) Johannes Klose et al.   PLoS One

Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation

(2013) Fengli Hu et al.   APOPTOSIS

Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials

(2013) M. Slingerland et al.   INVESTIGATIONAL NEW DRUGS

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells

(2013) P Cheng et al.   Cell Death & Disease

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

(2012) Tiejun Zhang et al.   Autophagy

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

(2012) Claudia Cerella et al.   MITOCHONDRION

RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex

(2012) B A Abhari et al.   ONCOGENE

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

(2011) Stephanos Pavlides et al.   ANTIOXIDANTS & REDOX SIGNALING

Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation

(2011) Chuan-Ming Xie et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chelation of Lysosomal Iron Protects Dopaminergic SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide Toxicity by Precluding Autophagy and Akt Dephosphorylation

(2011) Roberta Castino et al.   TOXICOLOGICAL SCIENCES

Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

(2010) Michael Schnekenburger et al.   BIOCHEMICAL PHARMACOLOGY

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

(2010) Tom Juncker et al.   BIOCHEMICAL PHARMACOLOGY

FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress

(2010) Arunima Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al2S4)

(2009) Claudia Cerella et al.   APOPTOSIS

UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death

(2009) Tom Juncker et al.   BIOCHEMICAL PHARMACOLOGY

TARGETING THE α 1 SUBUNIT OF THE SODIUM PUMP TO COMBAT GLIOBLASTOMA CELLS

(2009) Florence Lefranc et al.   NEUROSURGERY

Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes

(2009) Flavia Radogna et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism

(2009) F. Radogna et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE