TLR9 regulates the autophagy–lysosome pathway to promote dendritic cell maturation and activation by activating the TRAF6‐cGAS‐STING pathway

STING controls energy stress-induced autophagy and energy metabolism via STX17

(2022) Yueguang Rong et al.   JOURNAL OF CELL BIOLOGY

Autophagy in lupus nephritis: A delicate balance between regulation and disease

(2022) Manuel Alfredo Podestà et al.   AUTOIMMUNITY REVIEWS

Dendritic cells in systemic lupus erythematosus: From pathogenesis to therapeutic applications

(2022) Juan Liu et al.   JOURNAL OF AUTOIMMUNITY

CREG1 promotes lysosomal biogenesis and function

(2021) Jie Liu et al.   Autophagy

CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling

(2021) Zhi-Quan Xu et al.   INFLAMMATION

Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury

(2021) Qinjie Liu et al.   Cell Death & Disease

Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA

(2020) Chetna Soni et al.   IMMUNITY

NCoR1 fine‐tunes type‐I IFN response in cDC1 dendritic cells by directly regulating Myd88‐IRF7 axis under TLR9

(2020) Abdul Ahad et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation

(2020) Arthid Thim-uam et al.   iScience

Toll-like receptor signalling in B cells during systemic lupus erythematosus

(2020) Simon Fillatreau et al.   Nature Reviews Rheumatology

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

(2019) Anping Li et al.   Journal of Hematology & Oncology

Ubiquitination of cGAS by TRAF6 regulates anti-DNA viral innate immune responses

(2019) Xianfei Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients

(2019) Xinran Yuan et al.   Nature Communications

Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation

(2019) Young-Chan Kim et al.   Nature Chemical Biology

Identification and isolation of splenic tissue resident macrophage subpopulations by flow cytometry

(2018) Satoshi Fujiyama et al.   INTERNATIONAL IMMUNOLOGY

β-Glucan induces autophagy in dendritic cells and influences T-cell differentiation

(2018) Jun Ding et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

(2017) Alexis Combes et al.   Nature Communications

Can the cargo control the car? Mitochondrial DNA as a stimulator of TLR9-mediated autophagosome–lysosome fusion

(2016) Lisa M Lindqvist   CELL DEATH AND DIFFERENTIATION

Update on Lupus Nephritis

(2016) Salem Almaani et al.   Clinical Journal of the American Society of Nephrology

Correlation between TLR9 Expression and Cytokine Secretion in the Clinical Diagnosis of Systemic Lupus Erythematosus

(2015) Hui Rao et al.   MEDIATORS OF INFLAMMATION

The regional function of cGAS/STING signal in multiple organs: One of culprit behind systemic lupus erythematosus?

(2015) Liang Ding et al.   MEDICAL HYPOTHESES

Suppression of systemic autoimmunity by the innate immune adaptor STING

(2015) Shruti Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency of Autophagy in Dendritic Cells Protects against Experimental Autoimmune Encephalomyelitis

(2014) Abhisek Bhattacharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCK8 negatively regulates the TLR9-induced activation of human peripheral blood pDCs by targeting TRAF6 signaling

(2013) Xianxian Jia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

Late Endosome/Lysosome-Localized Rab7b Suppresses TLR9-Initiated Proinflammatory Cytokine and Type I IFN Production in Macrophages

(2009) M. Yao et al.   JOURNAL OF IMMUNOLOGY