Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury

Circulating mitochondrial DNA is a pro-inflammatory DAMP in sickle cell disease

(2021) Laxminath Tumburu et al.   BLOOD

Mitochondrial Regulation of Macrophage Response Against Pathogens

(2021) Subhadip Choudhuri et al.   Frontiers in Immunology

Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15

(2020) EunBin Kong et al.   CELL DEATH AND DIFFERENTIATION

Structural Insights into STING Signaling

(2020) Sabrina L. Ergun et al.   TRENDS IN CELL BIOLOGY

Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formation

(2020) Joanne Wei Kay Ku et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive Plasma Mitochondrial DNA is Associated with Disease Progression in Scleroderma Associated Interstitial Lung Disease

(2020) Changwan Ryu et al.   Arthritis & Rheumatology

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

(2020) Ana Copaescu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion

(2020) Xufei Zhang et al.   Cell Death & Disease

STING-dependent autophagy suppresses Nosema bombycis infection in silkworms, Bombyx mori

(2020) Xiaoting Hua et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

STING-dependent induction of lipid peroxidation mediates intestinal ischemia-reperfusion injury

(2020) Jie Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Changes in the Levels of Damage-Associated Molecular Patterns Following Continuous Veno–Venous Hemofiltration Therapy on Outcomes in Acute Kidney Injury Patients With Sepsis

(2019) Jie Wu et al.   Frontiers in Immunology

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

Degree of STING activation is associated with disease outcomes

(2019) Qiongyuan Hu et al.   GUT

The Role of Autophagy in Sepsis: Protection and Injury to Organs

(2019) Xin Yin et al.   Frontiers in Physiology

Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients

(2019) Hilary E. Faust et al.   CHEST

Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

(2019) Wei Luo et al.   CIRCULATION

Sepsis roadmap: What we know, what we learned, and where we are going

(2019) Vijay Kumar   CLINICAL IMMUNOLOGY

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

(2018) Yuxiao Sun et al.   CIRCULATION

PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT

(2018) Meizi Qian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute Respiratory Distress Syndrome

(2018) Eddy Fan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury

(2018) Amar Abdullah et al.   Journal of Neuroinflammation

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

(2018) Sulayman Benmerzoug et al.   Nature Communications

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

(2018) Katerina Gkirtzimanaki et al.   Cell Reports

Autophagy in sepsis: Degradation into exhaustion?

(2016) Jeffery Ho et al.   Autophagy

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

An Autophagic Flux Probe that Releases an Internal Control

(2016) Takeshi Kaizuka et al.   MOLECULAR CELL

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS

(2015) Kirsten Neudoerffer Kangelaris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Mortality Rates for Patients With Acute Lung Injury/ARDS Have Decreased Over Time

(2008) Massimo Zambon et al.   CHEST

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE