Kinetics of trisulfide-to-disulfide conversion of therapeutic IgG1 monoclonal antibodies under physiological conditions: a case study of casirivimab and imdevimab

Stabilities of Three Key Biological Trisulfides with Implications for Their Roles in the Release of Hydrogen Sulfide and Bioaccumulation of Sulfane Sulfur

(2022) Eric M. Brown et al.   ACS Omega

Liquid Chromatography-Multiple Reaction Monitoring-Mass Spectrometry Assay for Quantitative Measurement of Therapeutic Antibody Cocktail REGEN-COV Concentrations in COVID-19 Patient Serum

(2021) Xuefei Zhong et al.   ANALYTICAL CHEMISTRY

Predictive In Vitro Vitreous and Serum Models and Methods to Assess Thiol-Related Quality Attributes in Protein Therapeutics

(2020) Y. Diana Liu et al.   ANALYTICAL CHEMISTRY

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

(2020) David M. Weinreich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modeling on-column reduction of trisulfide bonds in monoclonal antibodies during protein A chromatography

(2017) Sanchayita Ghose et al.   JOURNAL OF CHROMATOGRAPHY A

Assessing in vivo dynamics of multiple quality attributes from a therapeutic IgG4 monoclonal antibody circulating in cynomolgus monkey

(2016) Yinyin Li et al.   mAbs

The thiol pool in human plasma: The central contribution of albumin to redox processes

(2013) Lucía Turell et al.   FREE RADICAL BIOLOGY AND MEDICINE

IgG2 disulfide isoform conversion kinetics

(2013) Yaoqing Diana Liu et al.   MOLECULAR IMMUNOLOGY

Evaluation of protein disulfide conversion in vitro using a continuous flow dialysis system

(2012) Xinzhao Grace Jiang et al.   ANALYTICAL BIOCHEMISTRY

Characterization of trisulfide modification in antibodies

(2010) Sheng Gu et al.   ANALYTICAL BIOCHEMISTRY

Efficient on-column conversion of IgG1 trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography

(2010) Hiromasa Aono et al.   JOURNAL OF CHROMATOGRAPHY A