Assessing in vivo dynamics of multiple quality attributes from a therapeutic IgG4 monoclonal antibody circulating in cynomolgus monkey

Affinity proteomics to study endogenous protein complexes: Pointers, pitfalls, preferences and perspectives

(2015) John LaCava et al.   BIOTECHNIQUES

Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL proteomics

(2015) Graziella E. Ronsein et al.   Journal of Proteomics

Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics

(2015) Richard S Rogers et al.   mAbs

A robust pipeline for rapid production of versatile nanobody repertoires

(2014) Peter C Fridy et al.   NATURE METHODS

Nanobody-based products as research and diagnostic tools

(2014) Thomas De Meyer et al.   TRENDS IN BIOTECHNOLOGY

IgG1 Thioether Bond Formationin Vivo

(2013) Qingchun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule

(2013) David Ouellette et al.   mAbs

Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies

(2012) Sheng Yin et al.   PHARMACEUTICAL RESEARCH

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

Rates and impact of human antibody glycation in vivo

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

N-terminal Glutamate to Pyroglutamate Conversionin Vivofor Human IgG2 Antibodies

(2011) Y. Diana Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

(2011) Weirong Wang et al.   MOLECULAR IMMUNOLOGY

C-terminal lysine processing of human immunoglobulin G2 heavy chain in vivo

(2010) Bing Cai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody

(2009) Pavlo Pristatsky et al.   ANALYTICAL CHEMISTRY

Human antibody Fc deamidation in vivo

(2009) Y. Diana Liu et al.   BIOLOGICALS

Immunoglobulin G4: an odd antibody

(2009) R. C. Aalberse et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

The effect of Fc glycan forms on human IgG2 antibody clearance in humans

(2008) X. Chen et al.   GLYCOBIOLOGY

Human IgG2 Antibody Disulfide Rearrangementin Vivo

(2008) Y. Diana Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY