Pharmacokinetics and Metabolism Investigation of Oleocanthal

Oleocanthal – Characterization, production, safety, functionality and in vivo evidences

(2023) Fernando Rivero-Pino   Food Chemistry

Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized Double-Blind Prospective Human Study

(2022) Christina Fytili et al.   Nutrients

Availability and Metabolic Fate of Olive Phenolic Alcohols Hydroxytyrosol and Tyrosol in the Human GI Tract Simulated by the In Vitro GIDM–Colon Model

(2022) Maria Eleni Sakavitsi et al.   Metabolites

Exploring the Immunotherapeutic Potential of Oleocanthal against Murine Cutaneous Leishmaniasis

(2022) Kalliopi Karampetsou et al.   PLANTA MEDICA

Metabolism and Bioavailability of Olive Bioactive Constituents Based on In Vitro, In Vivo and Human Studies

(2022) Theodora Nikou et al.   Nutrients

Absorption, Distribution, Metabolism, and Excretion of the Main Olive Tree Phenols and Polyphenols: A Literature Review

(2021) Sebastià Galmés et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique

(2021) Anallely López-Yerena et al.   Pharmaceutics

Tissue Distribution of Oleocanthal and Its Metabolites after Oral Ingestion in Rats

(2021) Anallely López-Yerena et al.   Antioxidants

Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats

(2020) López-Yerena et al.   Pharmaceutics

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases

(2020) María Luisa Castejón et al.   Antioxidants

Biomimetic Synthesis of Oleocanthal, Oleacein, and Their Analogues Starting from Oleuropein, A Major Compound of Olive Leaves

(2020) Georgia Sarikaki et al.   JOURNAL OF NATURAL PRODUCTS

The Inhibitory Effect of Extra Virgin Olive Oil and Its Active Compound Oleocanthal on Prostaglandin-Induced Uterine Hypercontraction and Pain—Ex Vivo and In Vivo Study

(2020) Yi-Fen Chiang et al.   Nutrients

Olive Oil Quality and Authenticity Assessment Aspects Employing FIA-MRMS and LC-Orbitrap MS Metabolomic Approaches

(2020) Theodora Nikou et al.   Frontiers in Public Health

(−)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

(2019) Abu Siddique et al.   Nutrients

Development of the LC-MS/MS method for determining the p-cresol level in plasma

(2019) Natalia Korytowska et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

(2019) Karković Marković et al.   MOLECULES

(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells

(2019) Limor Goren et al.   PLoS One

Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?

(2019) Abdullah Al Shoyaib et al.   PHARMACEUTICAL RESEARCH

Oleocanthalic and Oleaceinic acids: New compounds from Extra Virgin Olive Oil (EVOO)

(2018) Apostolis Angelis et al.   Phytochemistry Letters

The Biological Activities of Oleocanthal from a Molecular Perspective

(2018) Kok-Lun Pang et al.   Nutrients

CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol

(2017) Jose Rodríguez-Morató et al.   FOOD CHEMISTRY

An integrated process for the recovery of high added-value compounds from olive oil using solid support free liquid-liquid extraction and chromatography techniques

(2017) Apostolis Angelis et al.   JOURNAL OF CHROMATOGRAPHY A

Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

(2017) Mesut Mete et al.   Turkish Neurosurgery

Hippurate as a metabolomic marker of gut microbiome diversity: Modulation by diet and relationship to metabolic syndrome

(2017) Tess Pallister et al.   Scientific Reports

Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol

(2016) Jose Rodríguez-Morató et al.   DRUG METABOLISM REVIEWS

Pharmacokinetics of Tyrosol Metabolites in Rats

(2016) Da-Hye Lee et al.   MOLECULES

Differential absorption and metabolism of hydroxytyrosol and its precursors oleuropein and secoiridoids

(2016) María-Carmen López de las Hazas et al.   Journal of Functional Foods

Bioactivity of phenolic acids: Metabolites versus parent compounds: A review

(2015) Sandrina A. Heleno et al.   FOOD CHEMISTRY

Oleocanthal Modulates Estradiol-Induced Gene Expression Involving Estrogen Receptor α

(2015) Annekathrin Keiler et al.   PLANTA MEDICA

Biological activities of the natural antioxidant oleuropein: Exceeding the expectation – A mini-review

(2015) Imed Hassen et al.   Journal of Functional Foods

Olive Phenolics as c-Met Inhibitors: (-)-Oleocanthal Attenuates Cell Proliferation, Invasiveness, and Tumor Growth in Breast Cancer Models

(2014) Mohamed R. Akl et al.   PLoS One

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

A Concise and Efficient Total Synthesis of Oleocanthal

(2013) Matteo Valli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaeaL.) leaf extract

(2013) Martin de Bock et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bioavailability of phenols from a phenol-enriched olive oil

(2011) Manuel Suárez et al.   BRITISH JOURNAL OF NUTRITION

(−)-Oleocanthal as a c-Met Inhibitor for the Control of Metastatic Breast and Prostate Cancers

(2011) Ahmed Elnagar et al.   PLANTA MEDICA

Exploratory analysis of human urine by LC–ESI-TOF MS after high intake of olive oil: understanding the metabolism of polyphenols

(2010) Rocío García-Villalba et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Human absorption of a supplement containing purified hydroxytyrosol, a natural antioxidant from olive oil, and evidence for its transient association with low-density lipoproteins

(2010) Maria González-Santiago et al.   PHARMACOLOGICAL RESEARCH

Sensory Characterization of the Irritant Properties of Oleocanthal, a Natural Anti-Inflammatory Agent in Extra Virgin Olive Oils

(2009) S. Cicerale et al.   CHEMICAL SENSES

Improved method for identifying and quantifying olive oil phenolic compounds and their metabolites in human plasma by microelution solid-phase extraction plate and liquid chromatography–tandem mass spectrometry

(2009) Manuel Suárez et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES