Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer′s and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies

Value of cerebrospinal fluid α-synuclein species as biomarker in Parkinson's diagnosis and prognosis

(2016) Lucilla Parnetti et al.   Biomarkers in Medicine

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity

(2016) Nicolas R Barthélemy et al.   JOURNAL OF PROTEOME RESEARCH

Protein biomarkers in Parkinson's disease: Focus on cerebrospinal fluid markers and synaptic proteins

(2016) Steffen Halbgebauer et al.   MOVEMENT DISORDERS

Advances in targeted proteomics and applications to biomedical research

(2016) Tujin Shi et al.   PROTEOMICS

Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis

(2015) Patrick Weydt et al.   ANNALS OF NEUROLOGY

Validation of a commercially available enzyme-linked immunoabsorbent assay for the quantification of human α-Synuclein in cerebrospinal fluid

(2015) Niels Kruse et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Quantification of CSF biomarkers using an electrochemiluminescence-based detection system in the differential diagnosis of AD and sCJD

(2015) Franc Llorens et al.   JOURNAL OF NEUROLOGY

Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study

(2015) Niels Kruse et al.   NEUROBIOLOGY OF AGING

Subtype and regional regulation of prion biomarkers in sporadic Creutzfeldt-Jakob disease

(2015) Franc Llorens et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A Practical Guide to Immunoassay Method Validation

(2015) Ulf Andreasson et al.   Frontiers in Neurology

Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity

(2015) Tessandra Stewart et al.   Acta Neuropathologica Communications

Increased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels

(2014) Sylvie Slaets et al.   Alzheimers & Dementia

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt–Jakob disease

(2014) Takashi Kasai et al.   JOURNAL OF NEUROLOGY

Intact Protein Analysis of Ubiquitin in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Differences in Alzheimer’s Disease and Frontotemporal Lobar Degeneration

(2014) Patrick Oeckl et al.   JOURNAL OF PROTEOME RESEARCH

In-depth Characterization of the Cerebrospinal Fluid (CSF) Proteome Displayed Through the CSF Proteome Resource (CSF-PR)

(2014) Astrid Guldbrandsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach

(2014) Steven A. Carr et al.   MOLECULAR & CELLULAR PROTEOMICS

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease

(2014) Oskar Hansson et al.   Alzheimers Research & Therapy

Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies

(2013) Adrien W. Schmid et al.   MOLECULAR & CELLULAR PROTEOMICS

Criteria for the diagnosis of corticobasal degeneration

(2013) M. J. Armstrong et al.   NEUROLOGY

α-Synucleinopathy phenotypes

(2013) Heather McCann et al.   PARKINSONISM & RELATED DISORDERS

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis of Patients With Dementia and/or Parkinsonian Disorders

(2012) Sara Hall et al.   ARCHIVES OF NEUROLOGY

α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system

(2012) Brit Mollenhauer et al.   JOURNAL OF NEURAL TRANSMISSION

Development of electrochemiluminescence-based singleplex and multiplex assays for the quantification of α-synuclein and other proteins in cerebrospinal fluid

(2012) Niels Kruse et al.   METHODS

Global Identification and Characterization of BothO-GlcNAcylation and Phosphorylation at the Murine Synapse

(2012) Jonathan C. Trinidad et al.   MOLECULAR & CELLULAR PROTEOMICS

Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration

(2012) Katrin Beyer et al.   MOLECULAR NEUROBIOLOGY

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects

(2012) Brit Mollenhauer et al.   NEUROSCIENCE LETTERS

Phosphorylated  -Synuclein in Parkinson's Disease

(2012) Y. Wang et al.   Science Translational Medicine

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

(2011) Evangelia Emmanouilidou et al.   PLoS One

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Early Aggregation Steps in α-Synuclein as Measured by FCS and FRET: Evidence for a Contagious Conformational Change

(2010) Sangeeta Nath et al.   BIOPHYSICAL JOURNAL

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases

(2010) Sarah Jesse et al.   JOURNAL OF NEUROLOGY

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

(2010) K. E. Paleologou et al.   JOURNAL OF NEUROSCIENCE

A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain

(2010) Masayo Fujita et al.   Nature Communications

γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein

(2009) Natalia Ninkina et al.   HUMAN MOLECULAR GENETICS

Alpha- and Gamma-Synuclein Proteins Are Present in Cerebrospinal Fluid and Are Increased in Aged Subjects with Neurodegenerative and Vascular Changes

(2008) E.B. Mukaetova-Ladinska et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Site-Specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes

(2008) Z. Wang et al.   DIABETES

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

(2008) Brit Mollenhauer et al.   EXPERIMENTAL NEUROLOGY

Cerebrospinal fluid biomarkers of neurodegeneration in chronic neurological diseases

(2008) Hayrettin Tumani et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood

(2008) Robin Barbour et al.   Neurodegenerative Diseases

A more efficient enzyme-linked immunosorbent assay for measurement of α-synuclein in cerebrospinal fluid

(2007) Wieneke J.A. van Geel et al.   JOURNAL OF NEUROSCIENCE METHODS

Solvent-induced collapse of α-synuclein and acid-denatured cytochrome c

(2002) Artemiza S. Morar et al.   PROTEIN SCIENCE