Review
Clinical Neurology
Jon B. Toledo, Carla Abdelnour, Rimona S. Weil, Daniel Ferreira, Federico Rodriguez-Porcel, Andrea Pilotto, Kathryn A. Wyman-Chick, Michel J. Grothe, Joseph P. M. Kane, Angela Taylor, Arvid Rongve, Sonja Scholz, James B. Leverenz, Bradley F. Boeve, Dag Aarsland, Ian G. McKeith, Simon Lewis, Iracema Leroi, John P. Taylor
Summary: Dementia with Le bodies (DLB) is clinically characterized by visual hallucinations, fluctuations, rapid eye movement (REM) sleep behavioral disorder, and parkinsonism. However, neuropathological studies have shown the coexistence of Alzheimer's disease, TAR DNA-binding protein 43 (TDP-43), and cerebrovascular pathologies in DLB cases. These co-pathologies should be taken into consideration in clinical trials for DLB individuals.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Anna Emdina, Peter Hermann, Daniela Varges, Sabine Nuhn, Stefan Goebel, Timothy Bunck, Fabian Maass, Matthias Schmitz, Franc Llorens, Niels Kruse, Paul Lingor, Brit Mollenhauer, Inga Zerr
Summary: The study suggests that CSF oc-synuclein may serve as a potential prognostic marker for disease progression, affective symptoms, and executive cognitive function in Parkinson's disease.
Article
Clinical Neurology
Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Deniz Yilmazer-Hanke, Sarah Anderl-Straub, Christine von Arnim, Lutz Froelich, Luis Aragao Gomes, Lucrezia Hausner, Andre Huss, Holger Jahn, Jochen Weishaupt, Albert C. Ludolph, Dietmar R. Thal, Markus Otto
Summary: A novel ELISA was established to evaluate beta-synuclein as a potential marker for Alzheimer's disease. The study found increased levels of beta-synuclein in the CSF of some patients, supporting its potential use as a marker of synaptic degeneration. Furthermore, beta-synuclein was localized in glutamatergic synapses, with its expression reduced in AD patients' brain tissue.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Junna Hayashi, John A. Carver
Summary: This article reviews the current literature on human βS to better understand its role in homeostasis and pathology. The structure of βS is discussed, as well as its ability to act as a molecular chaperone, regulate synaptic function and other cellular pathways. The mutations associated with dementia with Lewy bodies are also explored, along with the impact of post-translational modifications on βS.
Review
Biochemistry & Molecular Biology
Paula M. Loveland, Jenny J. Yu, Leonid Churilov, Nawaf Yassi, Rosie Watson
Summary: This study reviewed inflammation investigation methods in Lewy body dementia (LBD) and identified alterations in inflammatory signals compared to individuals without neurodegenerative disease and other neurodegenerative diseases. The results suggest that both the innate and adaptive immune system contribute to inflammation associated with LBD pathology and clinical features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Fabricio Ferreira de Oliveira, Marjorie Camara Miraldo, Eduardo Ferreira de Castro-Neto, Sandro Soares de Almeida, Sandro Luiz de Andrade Matas, Paulo Henrique Ferreira Bertolucci, Maria da Graca Naffah-Mazzacoratti
Summary: Behavioral features may predict proteinopathies in neurodegenerative diseases, study examined associations of CSF biomarkers with neuropsychiatric features in DLB compared with AD and controls. DLB patients showed more intense behavioral burden, biomarker ratios were similar to AD, and APOE epsilon 4 status influenced amyloidogenesis and tau pathology differently in DLB and AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Sarah Holper, Rosie Watson, Nawaf Yassi
Summary: The advances in tau detection have revolutionized the diagnosis of neurodegenerative diseases, offering improved diagnostic accuracy and potential as a predictor of clinical progression and drug therapy response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Amber Nous, Mandy Melissa Jane Wittens, Yannick Vermeiren, Peter Paul De Deyn, Christine Van Broeckhoven, Guy Nagels, Ilse Smolders, Sebastiaan Engelborghs
Summary: This study aimed to evaluate the correlation between serum melatonin levels and spinal CSF melatonin levels in AD. The results showed a positive correlation between daytime serum melatonin levels and spinal CSF melatonin levels in AD patients, but no correlation was found between daytime melatonin levels and changes in cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medical Laboratory Technology
Camilla Steen Jensen, Helena Sophia Gleerup, Christian Sandoe Musaeus, Steen Gregers Hasselbalch, Peter Hogh, Gunhild Waldemar, Anja Hviid Simonsen
Summary: This study examined the levels of glucose in the cerebrospinal fluid (CSF) and plasma, as well as the CSF/plasma glucose ratio, in a large cohort from a mixed memory clinic population. The results showed that these measures were not able to differentiate between healthy controls and patients with different types of dementia disorders.
CLINICAL BIOCHEMISTRY
(2023)
Article
Neurosciences
Rui Pan, Shuyi Luo, Qing Huang, Weiwei Li, Tianshu Cai, Kelin Lai, Xiaolei Shi
Summary: This study investigated the associations of iron accumulation with neurodegenerative and inflammatory changes in Alzheimer's disease. The results showed that CSF ferritin levels were related to cognitive performance and other biomarkers, and higher levels were observed in more advanced stages of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Karolina Minta, Gunnar Brinkmalm, Erik Portelius, Per Johansson, Johan Svensson, Petronella Kettunen, Anders Wallin, Henrik Zetterberg, Kaj Blennow, Ulf Andreasson
Summary: The study identified that the concentrations of brevican and neurocan peptides were significantly decreased in the cerebrospinal fluid of VaD patients, suggesting their potential as diagnostic biomarkers for VaD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Zhen Hong, Chen Tian, Tessandra Stewart, Patrick Aro, David Soltys, Matt Bercow, Lifu Sheng, Kayla Borden, Tarek Khrisat, Catherine Pan, Cyrus P. Zabetian, Elaine R. Peskind, Joseph F. Quinn, Thomas J. Montine, Jan Aasly, Min Shi, Jing Zhang
Summary: Through sensitive nanoscale flow cytometry assays, it was found that total a-syn-positive and aggregated a-syn-positive EVs in CSF may serve as a helpful tool in PD diagnosis.
Article
Neurosciences
Sara Hall, Christina D. Orru, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman, Charles H. Adler, Thomas G. Beach, Byron Caughey, Oskar Hansson
Summary: This study used α Syn RT-QuIC to analyze CSF samples from patients with Lewy body disorders (LBD), and found that it has high sensitivity and specificity for identifying LBD cases with clinicopathological confirmation. However, it has lower sensitivity for non-standard LBD or asymptomatic LBD cases.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Neurosciences
Seyyed Hani Moussavi Nik, Tenielle Porter, Morgan Newman, Benjamin Bartlett, Imran Khan, Miheer Sabale, Melissa Eccles, Amy Woodfield, David Groth, Vincent Dore, Victor L. Villemagne, Colin L. Masters, Ralph N. Martins, Simon M. Laws, Michael Lardelli, Giuseppe Verdile
Summary: The study found that PS2V is upregulated in the brains of Alzheimer's disease patients but also present at significant levels in other dementia patients. The transcript of PS2V was detected in lymphocytes, and the ratio of PS2V/PSEN2 was significantly increased in mild cognitive impairment and AD groups compared to the control group, with this increase in ratio significantly correlated with hippocampal volume.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Sanna Read, Bo Hu, Josie Dixon, Nicola Brimblecombe, Raphael Wittenberg, Carol Brayne, Sube Banerjee
Summary: Compared to individuals with intact memory/orientation, people with dementia or low memory/orientation reported more unmet needs and unrequired help. These challenges were particularly pronounced for individuals with poorer cognition and potentially in the early stages of dementia, and were associated with lower quality of life.
AGING & MENTAL HEALTH
(2023)
Article
Geriatrics & Gerontology
Rotem Perach, Sanna Read, Ben Hicks, Peter R. Harris, Jennifer Rusted, Carol Brayne, Margaret Dangoor, Eleanor Miles, Josie Dixon, Louise Robinson, Alan Thomas, Sube Banerjee
Summary: This study aims to identify factors that predict loneliness for individuals with dementia and their caregivers during the COVID-19 pandemic. The study found that caregiver's loneliness was directly associated with caregiver type, anxiety levels, formal day activities, and cognitive impairment. For individuals with dementia, caregiver type, initial levels of social resources, wellbeing, and cognitive impairment predicted changes in loneliness through indirect effects on social contacts.
AGING & MENTAL HEALTH
(2023)
Article
Geriatrics & Gerontology
Connor D. Richardson, Hannah Roscoe, Emma Green, Racheal Brooks, Linda Barnes, Fiona E. Matthews, Carol Brayne
Summary: The prevalence of loneliness among older people has increased during the COVID-19 pandemic compared to before. Factors associated with prevalent loneliness include prior loneliness, living alone, being female, living in a deprived area, separation from family during the pandemic, and frequent pre-pandemic social contact at community groups. Weekly technology-mediated contact using telephone or video calls is associated with lower odds of loneliness.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Multidisciplinary Sciences
Deborah L. O. King, Richard Henson, Rogier Kievit, Noham Wolpe, Carol Brayne, Lorraine K. Tyler, James B. A. Rowe, Kamen A. Tsvetanov, Cam-CAN
Summary: Cardiovascular ageing is associated with cognitive impairment, but the specific contributions of different cardiovascular factors to cognitive function are not clear.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Sebastian Walsh, Ishtar Govia, Ruth Peters, Edo Richard, Blossom C. M. Stephan, Nikki-Anne Wilson, Lindsay Wallace, Kaarin J. Anstey, Carol Brayne
Summary: Dementia is a global public health challenge, and individual-level prevention strategies have limited potential. A population-level approach is needed to reduce the incidence of dementia and address global inequalities in risk. This approach can be highly cost-effective.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Sebastian Walsh, Carol Brayne
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Clinical Neurology
Gladys Maestre, Maria Carrillo, Raj Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Kazeem Akinwande, Joshua Akinyemi, Rufus Akinyemi, Onoja Akpa, Suvarna Alladi, Ricardo Allegri, Raul Arizaga, Faheem Arshad, Oyedunni Arulogun, David Ndetei, Olusegun Baiyewu, Thomas Issac, Tarek Bellaj, Judith Boshe, Carol Brayne, David Brodie-Mends, Richard Brown, Jennifer Cahn, Nkouonlack Cyrille, Albertino Damasceno, Ranil de Silva, Rohan de Silva, Mamuka Djibuti, Anna Jane Dreyer, Ratnavalli Ellajosyula, Temitope Farombi, Bernard Fongang, Stefania Forner, Rob Friedland, Noe Garza, Antoine Gbessemehlan, Eliza (Eleni-Zacharoula) Georgiou, Riadh Gouider, Ishtar Govia, Lea Grinberg, Maelenn Guerchet, Seid Gugssa, Joy Louise Gumikiriza-Onoria, Deborah Gustafson, Eef Hogervorst, Michael Hornberger, Agustin Ibanez, Masafumi Ihara, Ozama Ismail, Thomas Issac, Linus Joensson, Celestin Kaputu, Wambui Karanja, Jackline Karungi, Desire Tshala-Katumbay, Brian Kunkle, Joseph H. Lee, Iracema Leroi, Raphaella Lewis, Gill Livingston, Francisco Lopera, Kamada Lwere, Facundo Manes, Lingani Mbakile-Mahlanza, Pedro Mena, Bruce Miller, Athanase Millogo, Abdul Mohamed, Christine Musyimi, Victoria Mutiso, Noeline Nakasujja, David Ndetei, Sam Nightingale, Alfred K. Njamnshi, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius Ogeng'o, Adesola Ogunniyi, Maira Okada De Oliveira, Njideka Okubadejo, Martin Orrell, Akintunde Orunmuyi, Mayowa Owolabi, Stella Paddick, Margaret A. Pericak-Vance, Zvezdan Pirtosek, Felix Potocnik, Bill Preston, Rema Raman, Kirti Ranchod, Mie Rizig, Monica Rosselli, Roy Deepa, Upal Roy, Marufjon Salokhiddinov, Mary Sano, Fred Sarfo, Claudia L. Satizabal, Diego Sepulveda-Falla, Sudha Seshadri, Claire Sexton, Ingmar Skoog, Peter St George-Hyslop, Claudia Suemoto, Jeremy Tanner, Prekshya Thapa, Kamadore Toure, Valentine Ucheagwu, Chinedu Udeh-Momoh, Victor Valcour, Jeffery Vance, Mathew Varghese, Jaime Vera, Richard Walker, Wendy Weidner, Walsh Sebastian, Patrice Whitehead Gay, Henrik Zetterberg, Yared Zewde
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Alex Tsui, Natalie Yeo, Samuel D. Searle, Helen Bowden, Katrin Hoffmann, Joanne Hornby, Arley Goslett, Maryse Weston-Clarke, David Lanham, Patrick Hogan, Anna Seeley, Mark Rawle, Nish Chaturvedi, Elizabeth L. Sampson, Kenneth Rockwood, Colm Cunningham, E. Wesley Ely, Sarah J. Richardson, Carol Brayne, Graciela Muniz Terrera, Zoe Tieges, Alasdair M. J. MacLullich, Daniel Davis
Summary: This study examines the relationship between cognitive function and the severity of delirium in older adults. The authors find a U-shaped relationship, indicating that both lower and higher cognitive function are associated with more severe delirium symptoms. This highlights the importance of cognitive function in the prevention and treatment of delirium.
Article
Public, Environmental & Occupational Health
Michelle C. Odden, Adina Zhang, Neal Jawadekar, Annabel Tan, Andrew E. Moran, M. Maria Glymour, Carol Brayne, Adina Zeki Al Hazzouri, Sebastian Calonico
Summary: Regression discontinuity design (RDD) is a quasi-experimental method used for causal inference. This study aims to estimate the effect of statins on myocardial infarction (MI) using RDD and compare it with other methods. The findings suggest that RDD is superior in replicating the protective effect of statins with MI, although precision is poor.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Zhirong Yang, Chang Wei, Xiaojuan Li, Jinqiu Yuan, Xuefeng Gao, Bingyu Li, Ziyi Zhao, Sengwee Toh, Xin Yu, Carol Brayne, Zuyao Yang, Feng Sha, Jinling Tang
Summary: This study found that the regular use of laxatives is associated with a higher risk of all-cause dementia, especially in individuals who use multiple types of laxatives or osmotic laxatives.
Article
Clinical Neurology
Mohammed D. Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E. Matthews, Li Su, Paul G. Ince, Stephen B. Wharton, Dennis Wang
Summary: This study applies machine learning approaches to identify critical features of Alzheimer-related pathologies associated with dementia. Results show that Braak neurofibrillary tangle stage, beta-amyloid, and cerebral amyloid angiopathy are the most important features for dementia classification. The best-performing dementia classifier achieved 79% sensitivity, 69% specificity, and 75% precision using the top eight neuropathological features.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Communication
Ahmet Begde, Manisha Jain, Maria Goodwin, Carol Brayne, Linda Barnes, Rachael Brooks, Emma Green, Connor Richardson, Tom Dening, Thomas Wilcockson, Eef Hogervorst
Summary: Technology is seen as a solution for the aging population in the UK to improve independence and health. However, factors such as age, gender, access to technology, and physical health affect older adults' willingness to use memory assistive and ADL supportive technologies. Healthcare providers, policymakers, and technology producers should target older people, females, and those with less access to technology to promote healthy and independent aging.
INFORMATION COMMUNICATION & SOCIETY
(2023)
Letter
Clinical Neurology
Sebastian Walsh, Richard Merrick, Carol Brayne
Article
Geriatrics & Gerontology
Emma Nichols, Richard Merrick, Simon Hay, Dibya Himali, Jayandra J. Himali, Sally Hunter, Hannah A. D. Keage, Caitlin S. Latimer, Matthew R. Scott, Jaimie Steinmetz, Jamie M. Walker, Stephen B. Wharton, Crystal Wiedner, Paul K. Crane, Dirk Keene, Lenore J. Launer, Fiona E. Matthews, Julie Schneider, Sudha Seshadri, Lon White, Carol Brayne, Theo Vos
Summary: This study aimed to harmonise neuropathology measures across multiple community-based autopsy cohorts and assess the prevalence, correlation, and co-occurrence of neuropathologies in the ageing population. The results showed that the co-occurrence of neuropathologies in older adults was strongly associated with dementia status, highlighting the complexity of underlying brain pathologies. Rating: 9 out of 10.
LANCET HEALTHY LONGEVITY
(2023)
Letter
Clinical Neurology
Sebastian Walsh, Richard Merrick, Carol Brayne