☆ 4.7 Article

Synthesis of isoindolinones via a ruthenium-catalyzed cyclization of N-substituted benzamides with allylic alcohols

CHEMICAL COMMUNICATIONS (2015)

期刊

CHEMICAL COMMUNICATIONS

卷 51, 期 14, 页码 2929-2932

出版社

ROYAL SOC CHEMISTRY

DOI: 10.1039/c4cc09877c

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Chemistry, Multidisciplinary

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DST, India [SR/S1/OC-26/2011]
CSIR

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摘要

Substituted aromatic and heteroaromatic amides reacted with substituted allylic alcohols in the presence of a ruthenium catalyst, AgSbF6 and a Cu(OAc)(2)center dot H2O oxidant, affording 3-substituted isoindolinone derivatives with diverse substituents in good to excellent yields. A possible reaction mechanism involving a five-membered ruthenacycle intermediate was proposed and strongly supported by experimental evidence.

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