PAR2 deficiency tunes inflammatory microenvironment to magnify STING signalling for mitigating cancer metastasis via anionic CRISPR/Cas9 nanoparticles

Postsurgical wound management and prevention of triple-negative breast cancer recurrence with a pryoptosis-inducing, photopolymerizable hydrogel

(2023) Dandan Mi et al.   JOURNAL OF CONTROLLED RELEASE

STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma

(2023) Jing Hu et al.   NATURE

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

(2022) Kyle M. Garland et al.   CHEMICAL REVIEWS

Prolonged activation of innate immune pathways by a polyvalent STING agonist

(2021) Suxin Li et al.   Nature Biomedical Engineering

Polymeric PD-L1 blockade nanoparticles for cancer photothermal-immunotherapy

(2021) Yunjian Yu et al.   BIOMATERIALS

Anticancer nano-delivery systems based on bovine serum albumin nanoparticles: A critical review

(2021) Raghu Solanki et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer

(2020) K.G.K. Deepak et al.   PHARMACOLOGICAL RESEARCH

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

(2020) Jesse M. Jaynes et al.   Science Translational Medicine

Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging

(2020) Yue Quan et al.   Oxidative Medicine and Cellular Longevity

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

(2020) Tuo Wei et al.   Nature Communications

PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR

(2020) Yuhong Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy

(2020) Hui Peng et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nanomedicinal delivery of stimulator of interferon genes agonists: recent advances in virus vaccination

(2020) Saborni Chattopadhyay et al.   Nanomedicine

CRISPR-Cas9 for cancer therapy: Opportunities and challenges

(2019) Minjiang Chen et al.   CANCER LETTERS

Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets

(2019) Yiran Liang et al.   SEMINARS IN CANCER BIOLOGY

An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

(2019) Brian C. Evans et al.   Nature Communications

PAR2 deficiency enhances myeloid cell-mediated immunosuppression and promotes colitis-associated tumorigenesis

(2019) Ziliang Ke et al.   CANCER LETTERS

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

(2018) Ling Li et al.   BIOMATERIALS

Evolutionary history of human colitis-associated colorectal cancer

(2018) Ann-Marie Baker et al.   GUT

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Hyaluronan Reduces Cationic Liposome-Induced Toxicity and Enhances the Antitumor Effect of Targeted Gene Delivery in Mice

(2018) Yanping Qian et al.   ACS Applied Materials & Interfaces

A multi-functional macrophage and tumor targeting gene delivery system for the regulation of macrophage polarity and reversal of cancer immunoresistance

(2018) Xiao-Yan He et al.   Nanoscale

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

PAR2 promotes M1 macrophage polarization and inflammation via FOXO1 pathway

(2018) Liang Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis

(2017) Jeonghyun Ahn et al.   Cell Reports

Hematopoietic Tissue Factor–Protease-Activated Receptor 2 Signaling Promotes Hepatic Inflammation and Contributes to Pathways of Gluconeogenesis and Steatosis in Obese Mice

(2015) Jing Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis

(2015) Shardool Jain et al.   BIOMATERIALS

Proteinase-activated Receptor 2 Promotes Cancer Cell Migration through RNA Methylation-mediated Repression of miR-125b

(2015) Lan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression

(2015) Haiqiang Cao et al.   JOURNAL OF CONTROLLED RELEASE

Ligand-Modified Human Serum Albumin Nanoparticles for Enhanced Gene Delivery

(2015) Jennifer Look et al.   MOLECULAR PHARMACEUTICS

Multifunctional, self-assembling anionic peptide-lipid nanocomplexes for targeted siRNA delivery

(2014) Aristides D. Tagalakis et al.   BIOMATERIALS

Proteinase-activated receptor-2 modulates human macrophage differentiation and effector function

(2013) Rachael Steven et al.   Innate Immunity

Protease activated receptor-2 induces migration of pancreatic cancer cells in an extracellular ATP dependent manner

(2013) Kun Shi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cationic Bovine Serum Albumin Based Self-Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer

(2013) Jianfeng Han et al.   Small

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Biodistribution of liposome/DNA systems after subcutaneous and intraperitoneal inoculation

(2009) Nadia S. Chiaramoni et al.   JOURNAL OF LIPOSOME RESEARCH