A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Inhibits Tumor Growth and Angiogenesis In Vivo

(2014) Taotao Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sensitization of cancer cells to radiation by selenadiazole derivatives by regulation of ROS-mediated DNA damage and ERK and AKT pathways

(2014) Qiang Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Retinoic acid regulates cell cycle genes and accelerates normal mouse liver regeneration

(2014) Hui-Xin Liu et al.   BIOCHEMICAL PHARMACOLOGY

The Combined Therapeutical Effect of Metal-based Drugs and Radiation Therapy: The Present Status of Research

(2014) C. Ceresa et al.   CURRENT MEDICINAL CHEMISTRY

Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling

(2014) Zhennan Zhao et al.   DALTON TRANSACTIONS

Selenadiazole derivatives as potent thioredoxin reductase inhibitors that enhance the radiosensitivity of cancer cells

(2014) Yuan-Wei Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationships of 2′-modified-4′-selenoarabinofuranosyl-pyrimidines as anticancer agents

(2014) Jin-Hee Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Radiotherapy with concurrent cisplatin-based doublet or weekly cisplatin for cervical cancer: A systematic review and meta-analysis

(2014) Fausto Petrelli et al.   GYNECOLOGIC ONCOLOGY

Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase

(2014) Zuandi Luo et al.   Metallomics

Selenium substitution endows cystine with radiosensitization activity against cervical cancer cells

(2014) Qiang Xie et al.   RSC Advances

Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol “Switch-on” Fluorescent Probes and Anti-Cancer Agents

(2013) Taotao Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

(2013) Marc Benderitter et al.   ANTIOXIDANTS & REDOX SIGNALING

Notch Inhibitor: a Promising Carcinoma Radiosensitizer

(2013) Shu-Dong Yu et al.   Asian Pacific Journal of Cancer Prevention

Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles

(2013) Yanyu Huang et al.   BIOMATERIALS

Newly developed strategies for improving sensitivity to radiation by targeting signal pathways in cancer therapy

(2013) Miao Ding et al.   CANCER SCIENCE

Emerging protein targets for metal-based pharmaceutical agents: An update

(2013) Andreia de Almeida et al.   COORDINATION CHEMISTRY REVIEWS

Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway

(2013) Cundong Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular Toxicity Induced by the Photorelease of a Caged Bioactive Molecule: Design of a Potential Dual-Action Ru(II) Complex

(2013) Mark A. Sgambellone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles

(2013) Marco Frasconi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategies for optimizing the response of cancer and normal tissues to radiation

(2013) Everett J. Moding et al.   NATURE REVIEWS DRUG DISCOVERY

Natural Borneol, a Monoterpenoid Compound, Potentiates Selenocystine-Induced Apoptosis in Human Hepatocellular Carcinoma Cells by Enhancement of Cellular Uptake and Activation of ROS-Mediated DNA Damage

(2013) Jianyu Su et al.   PLoS One

Cetuximab, Paclitaxel, Carboplatin, and Radiation for Head and Neck Cancer

(2012) Ariel Birnbaum et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

(2012) Erin Wachter et al.   CHEMICAL COMMUNICATIONS

Ruthenium complexes containing 2,6-bis(benzimidazolyl)pyridine derivatives induce cancer cell apoptosis by triggering DNA damage-mediated p53 phosphorylation

(2012) Linlin Li et al.   DALTON TRANSACTIONS

Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

(2012) Brock S. Howerton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage

(2012) Shane Zaidi et al.   PLoS One

Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor

(2011) D. Wei et al.   CANCER RESEARCH

Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors

(2011) C. Diepart et al.   CANCER RESEARCH

Ruthenium complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers

(2011) Linlin Li et al.   DALTON TRANSACTIONS

Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase

(2011) Edward A. Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex

(2011) Flavia Barragán et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Radiosensitization of Cells Expressing Truncated DNA Polymerase  

(2010) S. Neijenhuis et al.   CANCER RESEARCH

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Reaching for the Other Side: Generating Sequence-Dependent Interstrand Cross-Links with 5-Bromodeoxyuridine and γ-rays†

(2009) Marie-Eve Dextraze et al.   BIOCHEMISTRY

Mechanism of Cellular Uptake of a Ruthenium Polypyridyl Complex†

(2008) Cindy A. Puckett et al.   BIOCHEMISTRY

Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion

(2007) Huawei Zeng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY