Article
Biochemical Research Methods
Harumi Kagiwada, Takayuki Kiboku, Hitomi Matsuo, Masashi Kitazawa, Kazuhiko Fukui, Katsuhisa Horimoto
Summary: Cellular protein phosphorylation is crucial for signal transduction, and the newly developed phosphorylation array system effectively assesses the activity of signaling pathways perturbed by external stimuli, offering a new approach to understanding intracellular signal transduction mechanisms.
Review
Pharmacology & Pharmacy
Meng Pan, Danrong Hu, Liping Yuan, Yan Yu, Yicong Li, Zhiyong Qian
Summary: Sonodynamic therapy (SDT) is a noninvasive treatment modality that utilizes low-frequency and low-intensity ultrasound to kill tumor cells. Gas-assisted therapy has been proposed to enhance the effectiveness of SDT. This review summarizes the mechanisms of SDT and gas-assisted SDT, introduces the applications of gas-assisted SDT for cancer therapy, and discusses the challenges and perspectives of gas-assisted SDT for future clinical applications.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Oncology
Nils-Petter Rudqvist, Manushak Avagyan, Dhan Chand
Summary: Radiation therapy and anti-CTLA-4 combination therapy can be effective for some patients, and adding CD40 may provide additional benefits. Next-generation anti-CTLA-4 antibodies like botensilimab show promise in clinical trials, and combining them with radiation therapy and/or CD40 agonist may offer additional benefits for challenging tumor types.
Article
Materials Science, Multidisciplinary
Hanan Al-Ghamdi, M. Elsafi, M. Sayyed, Aljawhara H. Almuqrin, P. Tamayo
Summary: This study prepared a group of heavy concrete samples containing varying concentrations of tungsten oxide, and studied the mechanical and radiation shielding properties of the samples using theoretical and experimental techniques. The results showed that adding WO3 and barite to the concrete increased the density and radiation shielding capability of the samples.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Review
Oncology
Xuejia Tang, Chenghai Zuo, Pengchao Fang, Guojing Liu, Yongyi Qiu, Yi Huang, Rongrui Tang
Summary: GBM remains the most lethal and common primary brain tumor, with poor prognosis mainly due to high rate of tumor recurrence caused by resistance to standard therapies. GSCs play a crucial role in GBM and are a key target for treatment, with research and targeted therapy showing promise in improving outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mohammad Habeeb, Huay Woon You, Kiran Balasaheb Aher, Girija Balasaheb Bhavar, Vidyarani Sujitkumar Khot, Shweta Mishra
Summary: Colorectal cancer (CRC) arises from genetic and epigenetic variations in the normal colon and rectum, causing the progression from adenomas to malignant tumors. Current treatment success rates for localized CRC range from 70 to 90%. Signaling pathways involved in multidrug resistance play a crucial role in CRC, making them potential targets for novel therapies. Nanotechnology has the potential to enhance cancer treatment by improving drug delivery systems. However, there are challenges and barriers that need to be overcome for effective utilization of nanomedicine in cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Optics
V Altunal, V Guckan, A. Ozdemir, Y. Zydhachevskyy, Y. Lawrence, Y. Yu, Z. Yegingil
Summary: This study investigated the structural, morphological, luminescent, and dosimetric characteristics of newly produced BeO based ceramic pellets, and compared them with commercially developed BeO Thermalox 995 chips. The BeO-based ceramics were prepared via co-precipitation synthesis method and their luminescence properties were studied for dosimetry applications. The newly developed BeO dosimeters showed high OSL sensitivity and good reproducibility, with a linear response to beta-radiation exposure.
JOURNAL OF LUMINESCENCE
(2022)
Article
Oncology
Zhangyi Luo, Katherine M. Eichinger, Anju Zhang, Song Li
Summary: Recent discoveries in cancer metabolism have identified potential metabolic targets to improve cancer therapy. However, the complexity of metabolic pathways and interactions between tumor cells and immune cells present challenges. Further research is needed to understand the differential effects of metabolic inhibition on cancer cells and immune cells and explore nanotechnology as a potential solution.
Review
Biochemistry & Molecular Biology
Zhi Zhu, A. J. Robert McGray, Weijian Jiang, Binfeng Lu, Pawel Kalinski, Zong Sheng Guo
Summary: Oncolytic viruses (OVs) are a new class of multi-modal immunotherapies for cancer, with the key to their effectiveness being the immune response they elicit. However, the clinical effectiveness of OV as a monotherapy is limited, leading researchers to explore combinations with other anti-cancer agents. The signaling pathways in cancer and immune cells offer promising targets for rational cancer therapy design. Small molecule modulators of these pathways have shown potential in enhancing anti-tumor immunity.
Review
Pharmacology & Pharmacy
Shin Ishikane, Masaki Arioka, Fumi Takahashi-Yanaga
Summary: Fibrosis occurs in all organs and tissues except the brain, leading to dysfunction and ultimately death. Myofibroblasts, which play a major role in fibrosis, are diverse in origin and can originate from various cell types. Despite significant progress in anti-cancer drug development, the development of anti-fibrotic agents has lagged. This review discusses the origin and transdifferentiation signaling pathways of myofibroblasts and explores the development of new drugs and repositioning of existing drugs for anti-fibrotic therapy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hao Xu, Wentao Wang, Xin Liu, Wei Huang, Chen Zhu, Yaozeng Xu, Huilin Yang, Jiaxiang Bai, Dechun Geng
Summary: Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous advances have occurred in targeted therapy. Bone-targeted therapy has been considered a promising therapeutic approach for handling the challenges in drug therapy for skeletal diseases. Recent advances in therapeutic strategies based on bone targeting, including targeting strategies based on bone structure and remodeling biology, as well as bone-targeted therapeutic agents and drug delivery strategies, are discussed in this review.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Brandi Miller, Rabina Mainali, Ravinder Nagpal, Hariom Yadav
Summary: The study found that synbiotic yogurt significantly reduced the development of diabetes induced by high-fat diet and streptozotocin, improved gut microbiota composition, and protected pancreatic islet morphology compared to the control yogurt.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Hongzheng Wu, Wanxin Chen, Zhenni Chen, Xianping Li, Min Wang
Summary: Organelles form tight connections at membrane contact sites, playing a crucial role in regulating homeostasis and cell function. The contact between endoplasmic reticulum (ER) and mitochondria is well known for its involvement in ion and lipid transport, ROS signaling, membrane dynamics, and cellular metabolism. However, the targeting mechanism and potential therapeutic targets at the mitochondria-associated endoplasmic reticulum membranes (MAM) for sensitizing traditional chemotherapy and developing new tumor therapeutic strategies have not been fully discussed. In this review, we highlight the key roles of signaling pathways at the ER-mitochondria contact site in tumorigenesis and focus on novel anticancer therapy strategies targeting potential MAM targets.
AGEING RESEARCH REVIEWS
(2023)
Review
Oncology
Adam Ioannou, Marianna Fontana, Julian D. Gillmore
Summary: This article discusses transthyretin (TTR), a protein that can misfold into amyloid fibrils and cause neuropathy and cardiomyopathy. Therapeutic strategies such as siRNA and ASO drugs have shown efficacy in reducing TTR synthesis. Several drugs have been licensed for the treatment of ATTR-PN, and early data suggest potential for ATTR-CM treatment as well.
Article
Chemistry, Multidisciplinary
Chunlan Pu, Shirui Wang, Lei Liu, Zhonghui Feng, Hongjia Zhang, Qianyuan Gong, Yueshan Sun, Yuanbiao Guo, Rui Li
Summary: Proteolysis targeting chimeras (PROTACs) are bifunctional degrader molecules that hijack the ubiquitin-proteasome system (UPS) to eliminate targeted proteins. Despite some PROTACs reaching clinical research, challenges such as poor oral bioavailability and potential toxic side effects still exist. This review provides an overview of recent strategies to improve PROTACs durability by enhancing cell permeability and reducing toxic side effects. The impact of these strategies on oral bioavailability, as well as their advantages and drawbacks, are discussed, aiming to provide a useful reference toolbox for PROTACs design and promote its clinical application.
CHINESE CHEMICAL LETTERS
(2023)
Review
Engineering, Biomedical
Shenglin Luo, Erlong Zhang, Yongping Su, Tianmin Cheng, Chunmeng Shi
Article
Engineering, Biomedical
Shenglin Luo, Xu Tan, Qingrong Qi, Qinyuan Guo, Xinze Ran, Lilong Zhang, Erlong Zhang, Yufeng Liang, Lingling Weng, Hu Zheng, Tianmin Cheng, Yongping Su, Chunmeng Shi
Article
Engineering, Biomedical
Erlong Zhang, Shenglin Luo, Xu Tan, Chunmeng Shi
Article
Engineering, Biomedical
Yang Wang, Tao Liu, Erlong Zhang, Shenglin Luo, Xu Tan, Chunmeng Shi
Article
Biotechnology & Applied Microbiology
M. Ding, E. Zhang, R. He, X. Wang, R. Li, W. Wang, Q. Yi
CANCER GENE THERAPY
(2012)
Article
Biotechnology & Applied Microbiology
Y. Peng, J. Yang, E. Zhang, H. Sun, Q. Wang, T. Wang, Y. Su, C. Shi
CANCER GENE THERAPY
(2012)
Correction
Biotechnology & Applied Microbiology
Miao Ding, Erlong Zhang, Rong He, Xingyong Wang, Rong Li, Weidong Wang, Qijian Yi
CANCER GENE THERAPY
(2012)
Review
Pharmacology & Pharmacy
Erlong Zhang, Chao Zhang, Yongping Su, Tianmin Cheng, Chunmeng Shi
DRUG DISCOVERY TODAY
(2011)
Article
Biotechnology & Applied Microbiology
Yixing Gao, Lan Feng, Luping Zhang, Jianhui Geng, Erlong Zhang
Summary: The study found that ATF4 promotes high expression of MTHFD2 in NSCLC through MYC mediation, indicating the important role of MTHFD2 in the development of NSCLC.