Article
Pharmacology & Pharmacy
Menglu Wang, Lina Ding, Chi Zhang, Huan Yu, Xinyu Ma, Xinming Wang, Fei Zhong, Qunlin Zhang
Summary: In this study, it was found that natural borneol (NB) can promote the cellular uptake of Piperlongumine (PL) in glioma cells, enhancing its therapeutic efficacy. This effect is achieved through down-regulation of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) expression. This work provides a new strategy for improving the efficacy of PL in glioma treatment.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ines Tawfik, Benjamin Gottschalk, Angelo Jarc, Doruntina Bresilla, Rene Rost, Barbara Obermayer-Pietsch, Wolfgang F. Graier, Corina T. Madreiter-Sokolowski
Summary: Thyroid hormones regulate mitochondrial Ca2+ uptake, leading to increased energy metabolism and reactive oxygen species production.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kah-Lok Thye, Wan Muhamad Asrul Nizam Wan Abdullah, Zetty Norhana Balia Yusof, Chien-Yeong Wee, Janna Ong-Abdullah, Jiun-Yan Loh, Wan-Hee Cheng, Dhilia Udie Lamasudin, Kok-Song Lai
Summary: This study found that lambda-carrageenan can significantly improve the growth of banana plants, including plant height, root length, pseudostem diameter, and fresh weight, at an optimum concentration. The treatment with lambda-carrageenan also increased root structure and facilitated nutrient uptake. Further research revealed that lambda-carrageenan increases chlorophyll content, protein content, and phenolic content, thereby enhancing photosynthesis rate, protein biosynthesis, and secondary metabolites biosynthesis, which ultimately stimulate the growth of banana plants. Additionally, lambda-carrageenan at the optimum concentration also increased catalase and peroxidase activities, leading to a reduction in hydrogen peroxide and malondialdehyde and maintaining cellular homeostasis in banana plants.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Faqian Shen, Yi Lin, Miriam Hoehn, Xianjin Luo, Markus Doeblinger, Ernst Wagner, Ulrich Laechelt
Summary: This study presents a versatile platform for the cellular delivery of various cargo peptides by integrating them into metallo-peptidic coordination nanoparticles. These nanoparticles can enhance the stability and membrane permeability of the peptides, making them efficient in delivering bioactive cargos into cells. The nanoparticles also generate reactive oxygen species (ROS) in cells, further enhancing their therapeutic potential.
Article
Biochemistry & Molecular Biology
Wen-Tsan Chang, Yung-Ding Bow, Yen-Chun Chen, Chia-Yang Li, Jeff Yi-Fu Chen, Yi-Ching Chu, Yen-Ni Teng, Ruei-Nian Li, Chien-Chih Chiu
Summary: The study demonstrates that the combination treatment of diTFPP and C-2-ceramide can significantly enhance cell death in HCC cells through disrupting sphingolipid metabolism, inhibiting cell cycle-related gene expression, inducing autophagy, and reactive oxygen species-responsive changes in gene expression.
Article
Oncology
Manting Sun, Dan Liu, Yang Yuan, Juhua Dan, Shuting Jia, Ying Luo, Jing Liu
Summary: This study reveals the mechanism by which compound IHZ-1 activates JNK in hepatocellular carcinoma through enhancing ROS generation and autophagy, leading to cell apoptosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
M. Brzezinski, W. Gonciarz, B. Kost, M. Chmiela
Summary: Histamine is involved in neurotransmission, inflammatory response, and immunity. It can enhance drug-loaded nanoparticles distribution, but the risk of deleterious effects limits its delivery. In this study, histamine was used as an initiator for lactide polymerization to prepare doxorubicin-loaded nanoparticles, which showed enhanced cytotoxicity towards gastric cancer cells and reduced production of ZO-1 protein. This strategy may lead to effective, targeted, and low-toxic delivery of drugs into cancer cells.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Chezhiyan Sumithaa, Tamilvelan Manjunathan, Olga Mazuryk, Silda Peters, Renjith S. Pillai, Malgorzata Brindell, Pushparathinam Gopinath, Mani Ganeshpandian
Summary: Organometallic compounds are promising candidates in the development of metallochemotherapeutics. In this study, two Ru(II)-pcymene complexes containing natural products were synthesized and characterized. These complexes exhibited higher cytotoxicity and antioxidant activity, and were shown to accumulate in melanoma cancer cells. Their cytotoxicity was positively correlated with cell uptake and mainly resulted from the induction of singlet oxygen production in cancer cells. The complexes also moderately altered the adhesion properties of cancer cells, which is beneficial for antimetastatic treatment.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Cristina de la Torre, Raquel Gavara, Alba Garcia-Fernandez, Maxim Mikhaylov, Maxim N. Sokolov, Juan F. Miravet, Felix Sancenon, Ramon Martinez-Manez, Francisco Galindo
Summary: By incorporating the hexanuclear molybdenum cluster into amino-decorated mesoporous silica nanoparticles, a new molybdenum-based hybrid photosensitizer was developed. The hybrid photosensitizer showed high porosity and efficient generation of singlet oxygen, making it effective for photodynamic therapy against human cervical cancer cells.
BIOMATERIALS ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Ping Wu, Siyuan Liu, Jianyu Su, Jianping Chen, Lin Li, Runguang Zhang, Tianfeng Chen
Article
Food Science & Technology
Xiaofeng Meng, Xiaomei Dong, Wen Wang, Liu Yang, Xia Zhang, Yanfang Li, Tianfeng Chen, Hang Ma, Da Qi, Jianyu Su
JOURNAL OF FOOD SCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Xia Zhang, Liting Wan, Lin Li, Zhenbo Xu, Jianyu Su, Bing Li, Jianrong Huang
Article
Agriculture, Multidisciplinary
Jingjing Luo, Xiaofeng Meng, Jianyu Su, Hang Ma, Wen Wang, Liming Fang, Huade Zheng, Yexia Qin, Tianfeng Chen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Nanjing Zhong, Zhongyu Gui, Li Xu, Jianrong Huang, Kun Hu, Yongqing Gao, Xia Zhang, Zhenbo Xu, Jianyu Su, Bing Li
LIPIDS IN HEALTH AND DISEASE
(2013)
Article
Biochemistry & Molecular Biology
Xia Zhang, Lin Li, He Xie, Zhili Liang, Jianyu Su, Guoqin Liu, Bing Li
Article
Multidisciplinary Sciences
Xia Zhang, Lin Li, Zhenbo Xu, Zhili Liang, Jianyu Su, Jianrong Huang, Bing Li
Article
Food Science & Technology
Longmei Weng, Lin Li, Lili Ji, Di Zhao, Zhenbo Xu, Jianyu Su, Bing Li, Xia Zhang
JOURNAL OF FOOD SCIENCE
(2019)
Article
Food Science & Technology
Ying Cai, Jingwei Guan, Wen Wang, Li Wang, Jianyu Su, Liming Fang
Summary: A novel, biodegradable, pH, and light-responsive composite film with enhanced antibacterial activity was developed, with the synergistic effects of Zn2+ and singlet oxygen contributing to a 99.9% reduction of Escherichia coli and Staphylococcus aureus strains, as well as a strong anti-adhesion property toward bacteria. This composite film shows great potential as an antibacterial packaging material for extending the shelf life of fruits, meat, and other food products.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Zhenhuan Song, Ting Liu, Haoqiang Lai, Xiaofeng Meng, Liu Yang, Jianyu Su, Tianfeng Chen
Summary: This study introduces a hydrothermal strategy assisted by ethylenediaminetetraacetic acid (EDTA) to synthesize polytypic bismuth telluride (Bi2Te3) nanoplates (BT NPs) with different sizes and morphologies. The size-dependent radio-sensitization and metabolism characteristics of BT NPs were investigated. The larger-sized BT NPs catalyzed the conversion of OH- to center dot OH, while the smaller-sized BT NPs produced higher O-1(2) levels, enhancing the radiotherapy effects. Metabolomic analysis revealed different metabolic pathways for larger and smaller BT NPs.
Article
Nanoscience & Nanotechnology
Shanshan Lai, Yanjiao Wang, Yuanyuan Wan, Hang Ma, Liming Fang, Jianyu Su
Summary: In this study, a smart magnetoelectric coating was developed to give stainless steel adjustable electrical properties and antibacterial effects. The antibacterial mechanism of the coating was also explored. This research provides a new solution for the hygiene and cleaning of food processing devices.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Liu Yang, Siyu Chen, Hongxin Wei, Yinzhu Luo, Feng Cong, Wende Li, Liangzhi Hong, Jianyu Su
Summary: The study developed a low-temperature PTT method based on borneol-containing polymer-modified MXene nanosheets, which effectively eliminates multidrug-resistant bacteria through targeted photothermal therapy and is safe for human use.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Qiwen Tang, Qi Ke, Qi Chen, Xinyi Zhang, Jianyu Su, Chengyun Ning, Liming Fang
Summary: A self-powered and intrinsic bactericidal patch based on a triboelectric nanogenerator (TENG) is proposed in this study. The patch is composed of electrospun polymer tribo-layers and a chemical vapor-deposited polypyrrole electrode, which provides excellent flexibility, breathability, and wettability. The patch kills over 96% of bacteria through electrical stimulation and promotes the healing of infected diabetic rat skin wounds within 2 weeks.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Lei Yin, Qiwen Tang, Qi Ke, Xinyi Zhang, Jianyu Su, Hua Zhong, Liming Fang
Summary: In this study, an antibacterial and proangiogenic dressing is developed by encapsulating DMOG in ZIF-8 and electrospinning it with Gel-PCL. The dressing sequentially releases bactericidal zinc ions and angiogenic DMOG molecules, eliminating bacterial infection and promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiaofeng Meng, Jingwei Guan, Shanshan Lai, Liming Fang, Jianyu Su
Summary: This paper reports a promising drug based on CCM incorporated into ZIF-8, which has high drug loading capability and drug release behavior, as well as excellent antibacterial activity. The experimental results suggest that ZIF@CCM can increase the permeability of bacterial cell membrane, thereby disrupting the bacterial cell membrane and achieving microbial inactivation.