Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation

(2023) Matthew J. Cuneo et al.   MOLECULAR CELL

Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

(2023) F Emil Thomasen et al.   eLife

A conceptual framework for understanding phase separation and addressing open questions and challenges

(2022) Tanja Mittag et al.   MOLECULAR CELL

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions

(2022) Mrityunjoy Kar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomolecular condensates and cancer

(2021) Ann Boija et al.   CANCER CELL

Structure–Function Properties in Disordered Condensates

(2021) Kamal Bhandari et al.   JOURNAL OF PHYSICAL CHEMISTRY B

How Hierarchical Interactions Make Membraneless Organelles Tick Like Clockwork

(2021) Jeremy D. Schmit et al.   TRENDS IN BIOCHEMICAL SCIENCES

The emerging role of SPOP protein in tumorigenesis and cancer therapy

(2020) Yizuo Song et al.   Molecular Cancer

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Beyond aggregation: Pathological phase transitions in neurodegenerative disease

(2020) Cécile Mathieu et al.   SCIENCE

Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

(2019) Lindsay B. Case et al.   SCIENCE

The ubiquitin ligase adaptor SPOP in cancer

(2019) Matthew J. Cuneo et al.   FEBS Journal

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation

(2019) Tae Hun Kim et al.   SCIENCE

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

Protein Network Structure Enables Switching between Liquid and Gel States

(2019) Jeremy D. Schmit et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

(2017) Hana Janouskova et al.   NATURE MEDICINE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

(2017) Tyler S Harmon et al.   eLife

Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles

(2016) Melissa R Marzahn et al.   EMBO JOURNAL

Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination

(2016) Wendy K. Pierce et al.   JOURNAL OF MOLECULAR BIOLOGY

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP

(2013) Laura K. van Geersdaele et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase

(2012) Wesley J. Errington et al.   STRUCTURE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

(2009) Qing Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of component exchange at PML nuclear bodies

(2008) S. Weidtkamp-Peters et al.   JOURNAL OF CELL SCIENCE