Mass spectrometry characterization of antibodies at the intact and subunit levels: From targeted to large-scale analysis
出版年份 2023 全文链接
标题
Mass spectrometry characterization of antibodies at the intact and subunit levels: From targeted to large-scale analysis
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume 492, Issue -, Pages 117117
出版商
Elsevier BV
发表日期
2023-08-17
DOI
10.1016/j.ijms.2023.117117
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Added Value of Internal Fragments for Top-Down Mass Spectrometry of Intact Monoclonal Antibodies and Antibody–Drug Conjugates
- (2023) Benqian Wei et al. Analytical Chemistry
- Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody
- (2023) Dario A. T. Cramer et al. mAbs
- Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern
- (2022) Danique M. H. van Rijswijck et al. Nature Communications
- Divergent Antibody Repertoires Found for Omicron versus Wuhan SARS-CoV-2 Strains Using Ig-MS
- (2022) Eleonora Forte et al. Journal of Proteome Research
- Generating Informative Sequence Tags from Antigen-Binding Regions of Heavily Glycosylated IgA1 Antibodies by Native Top-Down Electron Capture Dissociation
- (2021) Jean-Francois Greisch et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Electron Transfer Dissociation Parameter Optimization Using Design of Experiments Increases Sequence Coverage of Monoclonal Antibodies
- (2021) Milos Cejkov et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Sequential Ion–Ion Reactions for Enhanced Gas-Phase Sequencing of Large Intact Proteins in a Tribrid Orbitrap Mass Spectrometer
- (2021) Jake T. Kline et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- High-Throughput Multi-attribute Analysis of Antibody-Drug Conjugates Enabled by Trapped Ion Mobility Spectrometry and Top-Down Mass Spectrometry
- (2021) Eli J. Larson et al. ANALYTICAL CHEMISTRY
- Epitope Mapping of Polyclonal Antibodies by Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS)
- (2021) Susanne Ständer et al. ANALYTICAL CHEMISTRY
- Mass Spectrometry-Based De Novo Sequencing of Monoclonal Antibodies Using Multiple Proteases and a Dual Fragmentation Scheme
- (2021) Weiwei Peng et al. JOURNAL OF PROTEOME RESEARCH
- Human plasma IgG1 repertoires are simple, unique, and dynamic
- (2021) Albert Bondt et al. Cell Systems
- Development of an efficient mAb quantification assay by LC-MS/MS using rapid on-bead digestion
- (2021) Huai-Hsuan Chiu et al. ANALYTICA CHIMICA ACTA
- Extending Native Top-Down Electron Capture Dissociation to MDa Immunoglobulin Complexes Provides Useful Sequence Tags Covering Their Critical Variable Complementarity-Determining Regions
- (2021) Jean-Francois Greisch et al. ANALYTICAL CHEMISTRY
- Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire
- (2021) Rafael D. Melani et al. JOURNAL OF PROTEOME RESEARCH
- Quantitative N-Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis
- (2021) Bastiaan L. Duivelshof et al. Pharmaceutics
- Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry
- (2020) Jared O. Kafader et al. JOURNAL OF PROTEOME RESEARCH
- Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes
- (2020) Jared O. Kafader et al. NATURE METHODS
- Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry
- (2020) Tobias P. Wörner et al. NATURE METHODS
- High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry
- (2020) William S. Sawyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comprehensive Middle-Down Mass Spectrometry Characterization of an Antibody–Drug Conjugate by Combined Ion Activation Methods
- (2020) Eleanor Watts et al. ANALYTICAL CHEMISTRY
- Top-Down Characterization of an Intact Monoclonal Antibody Using Activated Ion Electron Transfer Dissociation
- (2020) Jean M. Lodge et al. ANALYTICAL CHEMISTRY
- Inter-laboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry
- (2020) Kristina Srzentic et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Intact and subunit-specific analysis of bispecific antibodies by sheathless CE-MS
- (2020) Christoph Gstöttner et al. ANALYTICA CHIMICA ACTA
- Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective
- (2020) John F. Kellie et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins
- (2019) Jared Otto Kafader et al. ANALYTICAL CHEMISTRY
- Top-down Mass Spectrometry Analysis of Human Serum Autoantibody Antigen-Binding Fragments
- (2019) Zhe Wang et al. Scientific Reports
- Classification of Plasma Cell Disorders by 21 Tesla Fourier Transform Ion Cyclotron Resonance Top-Down and Middle-Down MS/MS Analysis of Monoclonal Immunoglobulin Light Chains in Human Serum
- (2019) Lidong He et al. ANALYTICAL CHEMISTRY
- Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches
- (2019) Frederik Lermyte et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Middle-Down Multi-Attribute Analysis of Antibody-Drug Conjugates with Electron Transfer Dissociation
- (2019) Bifan Chen et al. ANALYTICAL CHEMISTRY
- A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry
- (2019) Oscar Hernandez-Alba et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Long-Range Conformational Changes in Monoclonal Antibodies Revealed Using FPOP-LC-MS/MS
- (2019) Owen Cornwell et al. ANALYTICAL CHEMISTRY
- Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry
- (2019) Rafael D. Melani et al. mAbs
- Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry
- (2019) Xiaobin Xu et al. PLoS One
- Direct Determination of Antibody Chain Pairing by Top-down and Middle-down Mass Spectrometry Using Electron Capture Dissociation and Ultraviolet Photodissociation
- (2019) Jared B. Shaw et al. ANALYTICAL CHEMISTRY
- Enhanced Sequence Coverage of Large Proteins by Combining Ultraviolet Photodissociation with Proton Transfer Reactions
- (2019) James D. Sanders et al. ANALYTICAL CHEMISTRY
- Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics
- (2019) Luca Fornelli et al. MOLECULAR & CELLULAR PROTEOMICS
- Enzyme-Containing Spin Membranes for Rapid Digestion and Characterization of Single Proteins
- (2018) Weijing Liu et al. ANALYST
- Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques
- (2018) Luca Fornelli et al. ANALYTICAL CHEMISTRY
- Complementary middle-down and intact monoclonal antibody proteoform characterization by capillary zone electrophoresis - Mass spectrometry
- (2018) Arseniy M. Belov et al. ELECTROPHORESIS
- Multiplexed Middle-Down Mass Spectrometry Reveals Light and Heavy Chain Connectivity in a Monoclonal Antibody
- (2018) Kristina Srzentic et al. ANALYTICAL CHEMISTRY
- Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry
- (2018) Yutong Jin et al. mAbs
- Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry
- (2018) Yuri E.M. van der Burgt et al. ANALYTICAL CHEMISTRY
- Activated Ion-Electron Transfer Dissociation Enables Comprehensive Top-Down Protein Fragmentation
- (2017) Nicholas M. Riley et al. JOURNAL OF PROTEOME RESEARCH
- Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer
- (2017) Luca Fornelli et al. Journal of Proteomics
- Mapping the Binding Interface of VEGF and a Monoclonal Antibody Fab-1 Fragment with Fast Photochemical Oxidation of Proteins (FPOP) and Mass Spectrometry
- (2017) Ying Zhang et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS
- (2017) Lidong He et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- The Immunoregulatory Roles of Antibody Glycosylation
- (2017) Madeleine F. Jennewein et al. TRENDS IN IMMUNOLOGY
- Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis
- (2016) Jonathan Sjögren et al. ANALYST
- Understanding the Impact of Methionine Oxidation on the Biological Functions of IgG1 Antibodies Using Hydrogen/Deuterium Exchange Mass Spectrometry
- (2016) Jingjie Mo et al. ANALYTICAL CHEMISTRY
- Characterization of Therapeutic Monoclonal Antibodies at the Subunit-Level using Middle-Down 193 nm Ultraviolet Photodissociation
- (2016) Victoria C. Cotham et al. ANALYTICAL CHEMISTRY
- Optimal Synthetic Glycosylation of a Therapeutic Antibody
- (2016) Thomas B. Parsons et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Progress in Top-Down Proteomics and the Analysis of Proteoforms
- (2016) Timothy K. Toby et al. Annual Review of Analytical Chemistry
- Determination of critical quality attributes for monoclonal antibodies using quality by design principles
- (2016) Nadja Alt et al. BIOLOGICALS
- Native Mass Spectrometry: What is in the Name?
- (2016) Aneika C. Leney et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Full validation of therapeutic antibody sequences by middle-up mass measurements and middle-down protein sequencing
- (2016) Anja Resemann et al. mAbs
- Ion Activation Methods for Peptides and Proteins
- (2015) Jennifer S. Brodbelt ANALYTICAL CHEMISTRY
- Hydrogen-Deuterium Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies
- (2015) Ranajoy Majumdar et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics
- (2015) Richard S Rogers et al. mAbs
- Advantages of Extended Bottom-Up Proteomics Using Sap9 for Analysis of Monoclonal Antibodies
- (2014) Kristina Srzentić et al. ANALYTICAL CHEMISTRY
- Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry
- (2014) Luca Fornelli et al. ANALYTICAL CHEMISTRY
- Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry
- (2014) Qingchun Zhang et al. mAbs
- Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry
- (2014) Sara Rosati et al. Nature Protocols
- Top-Down Structural Analysis of an Intact Monoclonal Antibody by Electron Capture Dissociation-Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry
- (2013) Yuan Mao et al. ANALYTICAL CHEMISTRY
- Proteoform: a single term describing protein complexity
- (2013) Lloyd M Smith et al. NATURE METHODS
- Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS
- (2012) Luca Fornelli et al. MOLECULAR & CELLULAR PROTEOMICS
- Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry
- (2011) Guillaume Chevreux et al. ANALYTICAL BIOCHEMISTRY
- Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry
- (2011) Yury O. Tsybin et al. ANALYTICAL CHEMISTRY
- Identification and characterization of oxidation and deamidation sites in monoclonal rat/mouse hybrid antibodies
- (2010) Vera Timm et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-orbitrap mass spectrometer
- (2009) Pavel V. Bondarenko et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Top-down N-terminal sequencing of Immunoglobulin subunits with electrospray ionization time of flight mass spectrometry
- (2008) Da Ren et al. ANALYTICAL BIOCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started