Inhibition of the Cyclin K‐CDK12 complex induces DNA damage and increases the effect of androgen deprivation therapy in prostate cancer
出版年份 2023 全文链接
标题
Inhibition of the Cyclin K‐CDK12 complex induces DNA damage and increases the effect of androgen deprivation therapy in prostate cancer
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF CANCER
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2023-11-02
DOI
10.1002/ijc.34778
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Emerging systemic treatment for metastatic castration-resistant prostate cancer: a review of recent randomized controlled trials
- (2023) Takafumi Yanagisawa et al. CURRENT OPINION IN UROLOGY
- Prognostic and clinicopathological value of CDK12 mutation in prostate cancer: a meta-analysis
- (2023) Wenjian Zhang et al. Expert Review of Anticancer Therapy
- Cancer statistics, 2022
- (2022) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Talazoparib plus enzalutamide in metastatic castration-resistant prostate cancer: TALAPRO-2 phase III study design
- (2022) Neeraj Agarwal et al. Future Oncology
- CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer
- (2022) Rui Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CRISPR screening identifies CDK12 as a conservative vulnerability of prostate cancer
- (2021) Hanqi Lei et al. Cell Death & Disease
- Nivolumab Reduces PD1 Expression and Alters Density and Proliferation of Tumor Infiltrating Immune Cells in a Tissue Slice Culture Model of Renal Cell Carcinoma
- (2021) Philipp J. Stenzel et al. Cancers
- Heterogeneity of genomic profile in patients with HER2-positive breast cancer
- (2020) Bo Chen et al. ENDOCRINE-RELATED CANCER
- Olaparib for Metastatic Castration-Resistant Prostate Cancer
- (2020) Johann de Bono et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
- (2020) Zhe Hong et al. MOLECULAR CELL
- EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent
- (2020) Nicolas Mottet et al. EUROPEAN UROLOGY
- CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability
- (2019) Seung H. Choi et al. GENES & DEVELOPMENT
- CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
- (2019) Anil Paul Chirackal Manavalan et al. EMBO REPORTS
- CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
- (2019) Malgorzata Krajewska et al. Nature Communications
- CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma
- (2019) Cun Wang et al. GUT
- Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma
- (2019) Meijuan Geng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
- (2018) Amanda Balboni Iniguez et al. CANCER CELL
- Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer
- (2018) Yi-Mi Wu et al. CELL
- Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trial
- (2018) Noel Clarke et al. LANCET ONCOLOGY
- Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
- (2018) Tingjun Lei et al. Nature Communications
- Role of Androgen Receptor in Prostate Cancer: A Review
- (2018) Kazutoshi Fujita et al. World Journal of Mens Health
- Genomic analysis of DNA repair genes and androgen signaling in prostate cancer
- (2018) Kasey Jividen et al. BMC CANCER
- State-of-the-art strategies for targeting the DNA damage response in cancer
- (2018) Patrick G. Pilié et al. Nature Reviews Clinical Oncology
- Cyclin K dependent regulation of Aurora B affects apoptosis and proliferation by induction of mitotic catastrophe in prostate cancer
- (2017) Sabrina Schecher et al. INTERNATIONAL JOURNAL OF CANCER
- WNT signalling in prostate cancer
- (2017) Virginia Murillo-Garzón et al. Nature Reviews Urology
- Ovarian Cancers Harboring Inactivating Mutations inCDK12Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications
- (2016) Tatiana Popova et al. CANCER RESEARCH
- Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
- (2016) Tinghu Zhang et al. Nature Chemical Biology
- Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition
- (2016) Olga Villamar et al. Oncotarget
- Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing
- (2015) Kaiwei Liang et al. MOLECULAR AND CELLULAR BIOLOGY
- Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
- (2015) Kingsley M. Ekumi et al. NUCLEIC ACIDS RESEARCH
- Cyclin D1 expression in prostate carcinoma
- (2014) R.A. Pereira et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- Comparative Genomic and Transcriptomic Analyses of LNCaP and C4-2B Prostate Cancer Cell Lines
- (2014) Lien Spans et al. PLoS One
- A Distinct Expression Pattern of Cyclin K in Mammalian Testes Suggests a Functional Role in Spermatogenesis
- (2014) Xiaocong Xiang et al. PLoS One
- Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
- (2013) I. Bajrami et al. CANCER RESEARCH
- Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate
- (2013) Sophia Lisette Maund et al. LABORATORY INVESTIGATION
- A Hormone-DNA Repair Circuit Governs the Response to Genotoxic Insult
- (2013) J. F. Goodwin et al. Cancer Discovery
- Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers
- (2013) W. R. Polkinghorn et al. Cancer Discovery
- PTEN in DNA damage repair
- (2012) Mei Ming et al. CANCER LETTERS
- Cyclin K goes with Cdk12 and Cdk13
- (2012) Jiri Kohoutek et al. Cell Division
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
- (2011) D. Blazek et al. GENES & DEVELOPMENT
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