CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
出版年份 2019 全文链接
标题
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
作者
关键词
-
出版物
EMBO REPORTS
Volume -, Issue -, Pages -
出版商
EMBO
发表日期
2019-07-26
DOI
10.15252/embr.201847592
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability
- (2019) Seung H. Choi et al. GENES & DEVELOPMENT
- Watchdog – a workflow management system for the distributed analysis of large-scale experimental data
- (2018) Michael Kluge et al. BMC BIOINFORMATICS
- EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
- (2018) Amanda Balboni Iniguez et al. CANCER CELL
- The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations
- (2018) Francesca Menghi et al. CANCER CELL
- A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response
- (2018) Takayuki Hoshii et al. CELL
- Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer
- (2018) Yi-Mi Wu et al. CELL
- Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation
- (2018) Johanna Fitz et al. EMBO JOURNAL
- Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
- (2018) Tingjun Lei et al. Nature Communications
- Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
- (2018) Gregory T. Booth et al. Nature Communications
- Tandem Duplications May Supply the Missing Genetic Alterations in Many Triple-Negative Breast and Gynecological Cancers
- (2018) Manisha Rao et al. CANCER CELL
- Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
- (2018) Seychelle M. Vos et al. NATURE
- CDK12 regulates DNA repair genes by suppressing intronic polyadenylation
- (2018) Sara J. Dubbury et al. NATURE
- The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
- (2017) Kevin M. Harlen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Splicing and transcription touch base: co-transcriptional spliceosome assembly and function
- (2017) Lydia Herzel et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion
- (2017) Jerry F. Tien et al. NUCLEIC ACIDS RESEARCH
- BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors
- (2017) Hana Paculová et al. TUMOR BIOLOGY
- CDK8 Kinase Activity Promotes Glycolysis
- (2017) Matthew D. Galbraith et al. Cell Reports
- Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks
- (2017) Ryan Baxley et al. Genes
- Ovarian Cancers Harboring Inactivating Mutations inCDK12Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications
- (2016) Tatiana Popova et al. CANCER RESEARCH
- The interaction of PRC2 with RNA or chromatin is mutually antagonistic
- (2016) Manuel Beltran et al. GENOME RESEARCH
- Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
- (2016) Tinghu Zhang et al. Nature Chemical Biology
- The pol II CTD: new twists in the tail
- (2016) Justyna Zaborowska et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The tandem duplicator phenotype as a distinct genomic configuration in cancer
- (2016) Francesca Menghi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The pol II CTD: new twists in the tail
- (2016) Justyna Zaborowska et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural and Functional Analysis of the Cdk13/Cyclin K Complex
- (2016) Ann Katrin Greifenberg et al. Cell Reports
- CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer
- (2016) Shawn F. Johnson et al. Cell Reports
- ContextMap 2: fast and accurate context-based RNA-seq mapping
- (2015) Thomas Bonfert et al. BMC BIOINFORMATICS
- Cdk12 is essential for embryonic development and the maintenance of genomic stability
- (2015) H-C Juan et al. CELL DEATH AND DIFFERENTIATION
- Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing
- (2015) Kaiwei Liang et al. MOLECULAR AND CELLULAR BIOLOGY
- DNA replication origin activation in space and time
- (2015) Michalis Fragkos et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
- (2015) Kingsley M. Ekumi et al. NUCLEIC ACIDS RESEARCH
- RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II
- (2015) M. Yu et al. SCIENCE
- 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells
- (2014) L. Davidson et al. GENES & DEVELOPMENT
- Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors
- (2014) Poorval M. Joshi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclin-Dependent Kinase 12 Increases 3′ End Processing of Growth Factor-Induced c-FOS Transcripts
- (2014) Tristan T. Eifler et al. MOLECULAR AND CELLULAR BIOLOGY
- The structure and substrate specificity of human Cdk12/Cyclin K
- (2014) Christian A. Bösken et al. Nature Communications
- Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons
- (2014) Iris Jonkers et al. eLife
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
- (2013) I. Bajrami et al. CANCER RESEARCH
- The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code
- (2013) Dirk Eick et al. CHEMICAL REVIEWS
- Causes and consequences of replication stress
- (2013) Michelle K. Zeman et al. NATURE CELL BIOLOGY
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Control of cell cycle transcription during G1 and S phases
- (2013) Cosetta Bertoli et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The ATM protein kinase: regulating the cellular response to genotoxic stress and more
- (2013) Yosef Shiloh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors
- (2013) Andreas R. Gruber et al. Wiley Interdisciplinary Reviews-RNA
- The cyclin K/Cdk12 complex
- (2012) Dalibor Blazek CELL CYCLE
- Detecting differential usage of exons from RNA-seq data
- (2012) S. Anders et al. GENOME RESEARCH
- Interaction of Cyclin-Dependent Kinase 12/CrkRS with Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II
- (2012) S.- W. G. Cheng et al. MOLECULAR AND CELLULAR BIOLOGY
- Gene-specific requirement of RNA polymerase II CTD phosphorylation
- (2012) Julie Drogat et al. MOLECULAR MICROBIOLOGY
- Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
- (2012) Karen Adelman et al. NATURE REVIEWS GENETICS
- Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
- (2012) Stéphane Larochelle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo
- (2012) Bo Gu et al. NUCLEIC ACIDS RESEARCH
- BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain
- (2012) B. N. Devaiah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclin K goes with Cdk12 and Cdk13
- (2012) Jiri Kohoutek et al. Cell Division
- Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
- (2011) Katharina Schlacher et al. CELL
- The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
- (2011) D. Blazek et al. GENES & DEVELOPMENT
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- c-Myc Regulates Transcriptional Pause Release
- (2010) Peter B. Rahl et al. CELL
- CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1
- (2010) B. Bartkowiak et al. GENES & DEVELOPMENT
- Fast and accurate short read alignment with Burrows-Wheeler transform
- (2009) H. Li et al. BIOINFORMATICS
- GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
- (2009) Eran Eden et al. BMC BIOINFORMATICS
- Spt6 enhances the elongation rate of RNA polymerase II in vivo
- (2009) M Behfar Ardehali et al. EMBO JOURNAL
- Phosphorylation of the Pol II CTD by KIN28 Enhances BUR1/BUR2 Recruitment and Ser2 CTD Phosphorylation Near Promoters
- (2009) Hongfang Qiu et al. MOLECULAR CELL
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- Defining mechanisms that regulate RNA polymerase II transcription in vivo
- (2009) Nicholas J. Fuda et al. NATURE
- Rates of in situ transcription and splicing in large human genes
- (2009) Jarnail Singh et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cracking the RNA polymerase II CTD code
- (2008) Sylvain Egloff et al. TRENDS IN GENETICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search