Cyclin K dependent regulation of Aurora B affects apoptosis and proliferation by induction of mitotic catastrophe in prostate cancer

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

(2017) Nicolas Mottet et al.   EUROPEAN UROLOGY

Ovarian Cancers Harboring Inactivating Mutations inCDK12Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications

(2016) Tatiana Popova et al.   CANCER RESEARCH

Role and therapeutic potential of CDK12 in human cancers

(2016) Rosaria Chilà et al.   CANCER TREATMENT REVIEWS

Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer

(2016) Santosh Gupta et al.   CLINICAL CANCER RESEARCH

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

(2016) Tinghu Zhang et al.   Nature Chemical Biology

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

Cdk12 is essential for embryonic development and the maintenance of genomic stability

(2015) H-C Juan et al.   CELL DEATH AND DIFFERENTIATION

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

(2015) Margaret M. Mc Gee   MEDIATORS OF INFLAMMATION

Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage

(2015) Francesco Marampon et al.   Oncotarget

Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

(2015) Juan Miguel Mosquera et al.   NEOPLASIA

Mitotic spindle multipolarity without centrosome amplification

(2014) Helder Maiato et al.   NATURE CELL BIOLOGY

A Distinct Expression Pattern of Cyclin K in Mammalian Testes Suggests a Functional Role in Spermatogenesis

(2014) Xiaocong Xiang et al.   PLoS One

Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability

(2014) M. Munoz-Barrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostate cancer biomarkers: An update

(2014) Javier Romero Otero et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity

(2013) I. Bajrami et al.   CANCER RESEARCH

Effect of cyclin G2 on proliferative ability of prostate cancer PC-3 cell

(2013) D. W. Cui et al.   TUMOR BIOLOGY

High-throughput SNP-based authentication of human cell lines

(2012) Felipe Castro et al.   INTERNATIONAL JOURNAL OF CANCER

Prostate Cancer Biochemical Recurrence Rates After Robotic-Assisted Laparoscopic Radical Prostatectomy

(2012) Serge Ginzburg et al.   JSLS-Journal of the Society of Laparoendoscopic Surgeons

Frequent Amplification of CENPF, GMNN and CDK13 Genes in Hepatocellular Carcinomas

(2012) Hye-Eun Kim et al.   PLoS One

Cyclin K goes with Cdk12 and Cdk13

(2012) Jiri Kohoutek et al.   Cell Division

p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737

(2011) Katrin E. Tagscherer et al.   APOPTOSIS

The Aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe

(2011) Yungan Tao et al.   CELL CYCLE

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Aurora B: A New Prognostic Marker and Therapeutic Target in Cancer

(2011) G. Portella et al.   CURRENT MEDICINAL CHEMISTRY

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study

(2011) Jack Cuzick et al.   LANCET ONCOLOGY

Enhanced Radiosensitivity of Androgen-Resistant Prostate Cancer: AZD1152-Mediated Aurora Kinase B Inhibition

(2011) Kenneth J Niermann et al.   RADIATION RESEARCH

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

(2010) J. den Hollander et al.   BLOOD

Overexpression of C-MYC oncogene in prostate cancer predicts biochemical recurrence

(2010) D Hawksworth et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Aurora B expression in post-puberal testicular germ cell tumours

(2009) Francesco Esposito et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High-throughput detection and multiplex identification of cell contaminations

(2009) M. Schmitt et al.   NUCLEIC ACIDS RESEARCH

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA