Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates

Testing preexisting antibodies prior to AAV gene transfer therapy: rationale, lessons and future considerations

(2022) Jerry R. Mendell et al.   Molecular Therapy-Methods & Clinical Development

Interests of the Non-Human Primate Models for HIV Cure Research

(2021) Gauthier Terrade et al.   Vaccines

Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS

(2021) Sonia Moretti et al.   Pathogens

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors

(2020) Giuseppe Ronzitti et al.   Frontiers in Immunology

Isolating Human Monoclonal Antibodies Against Adeno-Associated Virus From Donors With Pre-existing Immunity

(2020) April R. Giles et al.   Frontiers in Immunology

Immune responses to retinal gene therapy using adeno-associated viral vectors – Implications for treatment success and safety

(2020) Kirsten Bucher et al.   PROGRESS IN RETINAL AND EYE RESEARCH

CRISPR based editing of SIV proviral DNA in ART treated non-human primates

(2020) Pietro Mancuso et al.   Nature Communications

Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods

(2020) Hemangi G. Chaudhari et al.   CRISPR Journal

Identification of preexisting adaptive immunity to Cas9 proteins in humans

(2019) Carsten T. Charlesworth et al.   NATURE MEDICINE

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

(2019) Prasanta K. Dash et al.   Nature Communications

Target-Specific Precision of CRISPR-Mediated Genome Editing

(2018) Anob M. Chakrabarti et al.   MOLECULAR CELL

HIVE-heptagon: A sensible variant-calling algorithm with post-alignment quality controls

(2017) Vahan Simonyan et al.   GENOMICS

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

(2016) R Kaminski et al.   GENE THERAPY

High-performance integrated virtual environment (HIVE): a robust infrastructure for next-generation sequence data analysis

(2016) Vahan Simonyan et al.   Database-The Journal of Biological Databases and Curation

Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence

(2016) Claire Deleage et al.   Current Opinion in Virology

Animal Models for HIV Cure Research

(2016) Benjamin B. Policicchio et al.   Frontiers in Immunology

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

(2013) Thomas J. Cradick et al.   NUCLEIC ACIDS RESEARCH

Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

(2010) Sylvie Boutin et al.   HUMAN GENE THERAPY