Antimicrobial potential of quaternary phosphonium salt compounds: a review

Phosphine chalcogenides and their derivatives from red phosphorus and functionalized pyridines, imidazoles, pyrazoles and their antimicrobial and cytostatic activity

(2023) Svetlana Malysheva et al.   BIOORGANIC CHEMISTRY

Synthetic Antibacterial Quaternary Phosphorus Salts Promote Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing

(2023) Liang-Wen Shi et al.   International Journal of Nanomedicine

Atom Economical QPCs: Phenyl-Free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants

(2023) Laura M. Thierer et al.   ACS Infectious Diseases

Soft QPCs: Biscationic Quaternary Phosphonium Compounds as Soft Antimicrobial Agents

(2023) Samantha R. Brayton et al.   ACS Infectious Diseases

Mitochondria-Targeted Curcumin: A Potent Antibacterial Agent against Methicillin-Resistant Staphylococcus aureus with a Possible Intracellular ROS Accumulation as the Mechanism of Action

(2023) Carmen-Ecaterina Leferman et al.   Antibiotics-Basel

Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance

(2022) Kyle J. Sommers et al.   ACS Infectious Diseases

Rigidity‐Activity Relationships of bisQPC Scaffolds against Pathogenic Bacteria

(2022) Aaron C. Spahr et al.   ChemMedChem

Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens

(2022) Dominik Arbon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Structure of Quaternary Phosphonium Salts Based on Phosphorylated Sterically Hindered Phenols

(2022) I. V. Galkina et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Synthesis, biological evaluation and structure-activity relationship of 2-(2-hydroxyaryl)alkenylphosphonium salts with potency as anti-MRSA agents

(2022) Natalia V. Terekhova et al.   BIOORGANIC CHEMISTRY

Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria

(2022) Cedric Dzidzor Kodjo Amengor et al.   HETEROATOM CHEMISTRY

Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates

(2022) Marina E. Michaud et al.   ACS Infectious Diseases

Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris

(2022) Martina Raschig et al.   ARCHIV DER PHARMAZIE

Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria

(2021) Olga V. Tsepaeva et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and characterization of azobenzene derivatives and azobenzene-imidazolium conjugates with selective antimicrobial potential

(2021) Halimah Funmilayo Babamale et al.   JOURNAL OF MOLECULAR STRUCTURE

Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome

(2021) Chih-Wei Chen et al.   Antibiotics-Basel

Triphenilphosphonium Analogs of Chloramphenicol as Dual-Acting Antimicrobial and Antiproliferating Agents

(2021) Julia A. Pavlova et al.   Antibiotics-Basel

Synthesis, antimicrobial activity and cytotoxicity of triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues

(2021) Irina Yu. Strobykina et al.   BIOORGANIC CHEMISTRY

Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties

(2021) Vadim V. Ermolaev et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fluorescein Derivatives as Antibacterial Agents Acting via Membrane Depolarization

(2020) Pavel A. Nazarov et al.   Biomolecules

Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action

(2020) Natalia V. Terekhova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent Development in Fluorescein derivatives

(2020) Mani Rajasekar   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, Surface Activity, and Biological Activities of Phosphonium and Metronidazole Salts

(2020) Miloš Lukáč et al.   JOURNAL OF SURFACTANTS AND DETERGENTS

The Similarities between Human Mitochondria and Bacteria in the Context of Structure, Genome, and Base Excision Repair System

(2020) Karolina Boguszewska et al.   MOLECULES

Plastoquinone In and Beyond Photosynthesis

(2020) Michel Havaux   TRENDS IN PLANT SCIENCE

Triphenylphosphonium conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis and cytotoxicity evaluation

(2020) Irina Yu. Strobykina et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and Antimicrobial Activity of (3-Formyl-4-hydroxybenzyl)triphenylphosphonium Chloride Acylhydrazones

(2020) M. R. Milenković et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Linking 7-Nitrobenzo-2-oxa-1,3-diazole (NBD) to Triphenylphosphonium Yields Mitochondria-Targeted Protonophore and Antibacterial Agent

(2020) I. R. Iaubasarova et al.   BIOCHEMISTRY-MOSCOW

Pharmacological characterization of a structurally new class of antibacterial compound, triphenyl-phosphonium conjugated diarylheptanoid: Antibacterial activity and molecular mechanism

(2020) Shweta Kumari et al.   JOURNAL OF BIOSCIENCES

Derivatization of Rosmarinic Acid Enhances its in vitro Antitumor, Antimicrobial and Antiprotozoal Properties

(2019) Silvia Bittner Fialová et al.   MOLECULES

Betulin and its derivatives as novel compounds with different pharmacological effects

(2019) Shayan Amiri et al.   BIOTECHNOLOGY ADVANCES

Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

(2019) Anna Hordyjewska et al.   PHYTOCHEMISTRY REVIEWS

Synthesis, Anticancer and Antibacterial Activity of Betulinic and Betulonic Acid C-28-Triphenylphosphonium Conjugates with Variable Alkyl Linker Length

(2019) Olga V. Tsepaeva et al.   Anti-Cancer Agents in Medicinal Chemistry

Antibacterial activity of new structural class of semisynthetic molecule, triphenyl-phosphonium conjugated diarylheptanoid

(2019) Shweta Kumari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis

(2019) José Ignacio Manzano et al.   JOURNAL OF MEDICINAL CHEMISTRY

New 1,3-oxazolylphosphonium salts as potential biocides: QSAR study, synthesis, antibacterial activity and toxicity evaluation

(2018) Maria M. Trush et al.   Letters in Drug Design & Discovery

Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides

(2018) Ezequiel Silva Nigenda et al.   MedChemComm

The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs

(2018) Huan Chen et al.   Frontiers in Microbiology

Phenothiazine: A Better Scaffold against Tuberculosis

(2018) Satheeshkumar Sellamuthu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation

(2018) Wenqiang Chang et al.   Nature Communications

Mitochondria-Targeted Drugs

(2018) Roman A. Zinovkin et al.   Current Molecular Pharmacology

Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion

(2017) Francisco José Fueyo González et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure–Activity Relationships and Membrane Targeting Properties

(2017) Tianming Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A review on metronidazole: an old warhorse in antimicrobial chemotherapy

(2017) David Leitsch   PARASITOLOGY

Synthesis, characterization and antimicrobial activity of β-aminovinylphosphonium salts derived from aromatic amino acids

(2017) Sergey A. Borodkin et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents

(2017) Ming Li et al.   ACS Medicinal Chemistry Letters

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design

(2017) Jianguo Li et al.   Frontiers in Neuroscience

Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity

(2016) Hangjun Ke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular mechanisms of membrane targeting antibiotics

(2016) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

(2016) Abdulsalam A.M. Alkhaldi et al.   International Journal for Parasitology-Drugs and Drug Resistance

Uncoupling and toxic action of alkyltriphenylphosphonium cations on mitochondria and the bacterium Bacillus subtilis as a function of alkyl chain length

(2015) L. S. Khailova et al.   BIOCHEMISTRY-MOSCOW

Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity

(2015) Leonel A. Cortes et al.   PLoS One

Tuning the hydrophobicity overcomes unfavorable deprotonation making octylamino-substituted 7-nitrobenz-2-oxa-1,3-diazole (n-octylamino-NBD) a protonophore and uncoupler of oxidative phosphorylation in mitochondria

(2014) Stepan S. Denisov et al.   BIOELECTROCHEMISTRY

Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis

(2014) Elyse A. Dunn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mitochondrial-Targeted Curcuminoids: A Strategy to Enhance Bioavailability and Anticancer Efficacy of Curcumin

(2014) Cheruku Apoorva Reddy et al.   PLoS One

Dodecyl and octyl esters of fluorescein as protonophores and uncouplers of oxidative phosphorylation in mitochondria at submicromolar concentrations

(2013) Maria M. Shchepinova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Small azobenzene derivatives active against bacteria and fungi

(2013) Stefano Piotto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sensitization of gram-negative bacteria by targeting the membrane potential

(2013) Keren Goldberg et al.   FASEB JOURNAL

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Phosphonium lipocations as antiparasitic agents

(2012) Timothy E. Long et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Subcellular Localization and Activity of Gambogic Acid

(2012) Gianni Guizzunti et al.   CHEMBIOCHEM

A Review on Biological Activities and Chemical Synthesis of Hydrazide Derivatives

(2012) R. Narang et al.   CURRENT MEDICINAL CHEMISTRY

Investigation of mutation distribution in DNA gyrase and topoisomerase IV genes in ciprofloxacin-non-susceptible Enterobacteriaceae isolated from blood cultures in a tertiary care university hospital in South Korea, 2005–2010

(2012) You Sun Nam et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synthesis and Structure–Activity Analysis of New Phosphonium Salts with Potent Activity against African Trypanosomes

(2012) Andrea Taladriz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antimicrobial Activities of Phosphonium Salts on Basis of Triphenylphosphine and 3,5-Di-Tert-Butyl-4-Hydroxybenzyl Bromide

(2012) Irina Galkina et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Phenothiazine: the seven lives of pharmacology's first lead structure

(2011) Maike J. Ohlow et al.   DRUG DISCOVERY TODAY

Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?

(2011) Gianni Guizzunti et al.   INVESTIGATIONAL NEW DRUGS

Natural salicylates: foods, functions and disease prevention

(2011) Garry G. Duthie et al.   Food & Function

Chemistry and Biology of the CagedGarciniaXanthones

(2010) Oraphin Chantarasriwong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects

(2010) Prabodh Chander Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

New Benzophenone-Derived Bisphosphonium Salts as Leishmanicidal Leads Targeting Mitochondria through Inhibition of Respiratory Complex II

(2010) J. Román Luque-Ortega et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Membrane potential is important for bacterial cell division

(2010) H. Strahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caged Garcinia Xanthones: Development Since 1937

(2009) Q.-B. Han et al.   CURRENT MEDICINAL CHEMISTRY

Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore

(2009) F. F. Severin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA