Subcellular Localization and Activity of Gambogic Acid

Mechanisms of Gambogic Acid-Induced Apoptosis in Non-Small Cell Lung Cancer Cells in Relation to Transferrin Receptors

(2014) Xiaoli Zhu et al.   JOURNAL OF CHEMOTHERAPY

Fused Xanthone Derivatives as Antiproliferative Agents

(2012) Nicole Pouli et al.   Anti-Cancer Agents in Medicinal Chemistry

Studies on chemical modification and biology of a natural product, gambogic acid (III): Determination of the essential pharmacophore for biological activity

(2011) Xiaojian Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Gambogic Acid, a Natural Product Inhibitor of Hsp90

(2011) Jason Davenport et al.   JOURNAL OF NATURAL PRODUCTS

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

(2011) A Lemarie et al.   ONCOGENE

Chemistry and Biology of the CagedGarciniaXanthones

(2010) Oraphin Chantarasriwong et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Synthetic Caged Garcinia Xanthone Cluvenone Induces Cell Stress and Apoptosis and Has Immune Modulatory Activity

(2010) A. Batova et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gambogic acid down-regulates MDM2 oncogene and induces p21Waf1/CIP1 expression independent of p53

(2009) Jing-Jing Rong et al.   CANCER LETTERS

Suppression of Tumor Growth In vivo by the Mitocan  -tocopheryl Succinate Requires Respiratory Complex II

(2009) L.-F. Dong et al.   CLINICAL CANCER RESEARCH

Caged Garcinia Xanthones: Development Since 1937

(2009) Q.-B. Han et al.   CURRENT MEDICINAL CHEMISTRY

General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent

(2009) Li Zhao et al.   DRUG AND CHEMICAL TOXICOLOGY

Targeting mitochondrial apoptosis by betulinic acid in human cancers

(2009) Simone Fulda et al.   DRUG DISCOVERY TODAY

Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells

(2009) Xiaoyuan Xu et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

(2009) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Mitochondria as targets for cancer therapy

(2009) Stephen J. Ralph et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Evaluation of the pharmacophoric motif of the caged Garcinia xanthones

(2009) Oraphin Chantarasriwong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells

(2009) Feifei Nie et al.   TOXICOLOGY

Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid

(2008) Jared Kuemmerle et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells

(2008) Qing Zhao et al.   CANCER LETTERS

Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor and reactive oxygen species

(2008) E Ortiz-Sánchez et al.   LEUKEMIA

Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells

(2008) Jing Chen et al.   LIFE SCIENCES

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

(2008) Dayong Zhai et al.   MOLECULAR CANCER THERAPEUTICS

Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

(2008) Hongyan Gu et al.   MOLECULAR CANCER THERAPEUTICS

Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma

(2008) Xin Wang et al.   PROTEOMICS

Inhibition of glioblastoma growth and angiogenesis by gambogic acid: An in vitro and in vivo study

(2007) Lei Qiang et al.   BIOCHEMICAL PHARMACOLOGY