Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens

Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro

(2021) Eva Doleželová et al.   Scientific Reports

Comprehensive understanding of multiple actions of anticancer drug tamoxifen in isolated mitochondria

(2021) Yufu Unten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action

(2020) Natalia V. Terekhova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Adaptive iron utilization compensates for the lack of an inducible uptake system in Naegleria fowleri and represents a potential target for therapeutic intervention

(2020) Dominik Arbon et al.   PLoS Neglected Tropical Diseases

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

(2019) Susan Wyllie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tamoxifen acts on Trypanosoma cruzi sphingolipid pathway triggering an apoptotic death process

(2019) Malena Landoni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Behavior of the DPH fluorescence probe in membranes perturbed by drugs

(2019) Chetan Poojari et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis

(2019) José Ignacio Manzano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Discovery of Novel Antiprotozoal Agents

(2019) Lee et al.   MOLECULES

Hardly Vacuous: The Parasitophorous Vacuolar Membrane of Malaria Parasites

(2019) Daniel E. Goldberg et al.   TRENDS IN PARASITOLOGY

Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum

(2018) Tamara A. Piñero et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

(2018) Sona Hubackova et al.   CELL DEATH AND DIFFERENTIATION

Iron economy in Naegleria gruberi reflects its metabolic flexibility

(2018) Jan Mach et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial

(2018) Victor Kande Betu Ku Mesu et al.   LANCET

Candida albicans - Biology, molecular characterization, pathogenicity, and advances in diagnosis and control – An update

(2018) Maryam Dadar et al.   MICROBIAL PATHOGENESIS

Giardia: an under-reported foodborne parasite

(2018) Una Ryan et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

(2018) Cristiana T. Trinconi et al.   International Journal for Parasitology-Drugs and Drug Resistance

Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion

(2017) Francisco José Fueyo González et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

(2017) Alena Zíková et al.   PLoS Pathogens

Cryptococcosis

(2016) Eileen K. Maziarz et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

(2016) Abdulsalam A.M. Alkhaldi et al.   International Journal for Parasitology-Drugs and Drug Resistance

Naegleria fowleri: Pathogenesis, Diagnosis, and Treatment Options

(2015) Eddie Grace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ADP/ATP Carrier and Its Relationship to Oxidative Phosphorylation in Ancestral Protist Trypanosoma brucei

(2015) Anna Gnipová et al.   EUKARYOTIC CELL

ATPaseTb2, a Unique Membrane-bound FoF1-ATPase Component, Is Essential in Bloodstream and Dyskinetoplastic Trypanosomes

(2015) Karolína Šubrtová et al.   PLoS Pathogens

Antiproliferative and Uncoupling Effects of Delocalized, Lipophilic, Cationic Gallic Acid Derivatives on Cancer Cell Lines. Validation in Vivo in Singenic Mice

(2014) José A. Jara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug repurposing and human parasitic protozoan diseases

(2014) Katherine T. Andrews et al.   International Journal for Parasitology-Drugs and Drug Resistance

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

(2013) Manu De Rycker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

(2013) ROB DON et al.   PARASITOLOGY

A Targeted and FRET-Based Ratiometric Fluorescent Nanoprobe for Imaging Mitochondrial Hydrogen Peroxide in Living Cells

(2013) Fangkai Du et al.   Small

Membrane fluidity and activity of membrane ATPases in human erythrocytes under the influence of polyhydroxylated fullerene

(2012) Jacek Grebowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Phosphonium lipocations as antiparasitic agents

(2012) Timothy E. Long et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold

(2012) JosÉ Teixeira et al.   FREE RADICAL RESEARCH

Synthesis and Structure–Activity Analysis of New Phosphonium Salts with Potent Activity against African Trypanosomes

(2012) Andrea Taladriz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

(2011) Miguel Shingu-Vazquez et al.   EUKARYOTIC CELL

Enigmatic Presence of Mitochondrial Complex I in Trypanosoma brucei Bloodstream Forms

(2011) Sachin Surve et al.   EUKARYOTIC CELL

Complex I (NADH:ubiquinone oxidoreductase) is active in but non-essential for procyclic Trypanosoma brucei

(2010) Zdeněk Verner et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY