Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors

Lecanemab (BAN2401): an anti–beta-amyloid monoclonal antibody for the treatment of Alzheimer disease

(2023) Grace E. Vitek et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

(2022) Honghua Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties

(2022) Joana Reis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synaptogenic effect of APP -Swedish mutation in familial Alzheimer’s disease

(2022) Bo Zhou et al.   Science Translational Medicine

Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer’s Disease

(2022) Xinnan Li et al.   ACS Chemical Neuroscience

Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease

(2022) Xinnan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease

(2021) Hong Yao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase

(2019) Bhupinder Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease

(2019) Tarana Umar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multi-target design strategies for the improved treatment of Alzheimer's disease

(2019) Pengfei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease

(2019) Divan G. van Greunen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents

(2018) Simone Carradori et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A novel selective MAO-B inhibitor with neuroprotective and anti-Parkinsonian properties

(2018) Hugh H. Chan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

(2018) K. Rajasekhar et al.   RSC Advances

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Indanones As High-Potency Reversible Inhibitors of Monoamine Oxidase

(2015) Samantha Mostert et al.   ChemMedChem

Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease

(2015) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Autophagy in Alzheimer’s disease

(2015) Ameneh Zare-shahabadi et al.   REVIEWS IN THE NEUROSCIENCES

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

(2014) Angel Agis-Torres et al.   Current Neuropharmacology

Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease

(2014) Neng Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release

(2014) John P.M. Finberg   PHARMACOLOGY & THERAPEUTICS

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases

(2012) L. Pisani et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

(2011) Anne Eckert et al.   Alzheimers Research & Therapy

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy

(2010) Elina Zotova et al.   Alzheimers Research & Therapy