Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivity

Selective inhibition of tumor cell associated Vacuolar-ATPase ‘a2’ isoform overcomes cisplatin resistance in ovarian cancer cells

(2016) Arpita Kulshrestha et al.   Molecular Oncology

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro

(2015) Svenja Petzoldt et al.   BIOMETALS

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

(2015) Helena Öhrvik et al.   JOURNAL OF IMMUNOLOGY

The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2)

(2015) Cheng-Yu Tsai et al.   Metallomics

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

(2015) Jing Wang et al.   Nature Chemistry

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function

(2015) Gin-Fu Chen et al.   Scientific Reports

Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria

(2014) Linhong Zhao et al.   CHEMICAL COMMUNICATIONS

Structural Biology of Cisplatin Complexes with Cellular Targets: The Adduct with Human Copper Chaperone Atox1 in Aqueous Solution

(2014) Vania Calandrini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Platination of the copper transporter ATP7A involved in anticancer drug resistance

(2014) Vania Calandrini et al.   DALTON TRANSACTIONS

Cisplatin handover between copper transporters: the effect of reducing agents

(2014) Angela Galliani et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes

(2014) Zhaoyong Xi et al.   Metallomics

Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin

(2014) Carlos P. Huang et al.   Metallomics

Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse

(2013) S. Jain et al.   ANNALS OF ONCOLOGY

Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification

(2013) Nataliya V. Dolgova et al.   BIOCHEMICAL JOURNAL

Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1

(2013) Zhaoyong Xi et al.   CHEMICAL COMMUNICATIONS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

CTR1 Silencing Inhibits Angiogenesis by Limiting Copper Entry into Endothelial Cells

(2013) Gomathy Narayanan et al.   PLoS One

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain

(2013) H. Ohrvik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells

(2013) Maria Palm-Espling et al.   PROTEIN AND PEPTIDE LETTERS

An All-Atom Model of the Structure of Human Copper Transporter 1

(2012) Igor F. Tsigelny et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Overcoming Platinum Resistance through the Use of a Copper-Lowering Agent

(2012) Siqing Fu et al.   MOLECULAR CANCER THERAPEUTICS

Mechanistic Basis for Overcoming Platinum Resistance Using Copper Chelating Agents

(2012) Z. D. Liang et al.   MOLECULAR CANCER THERAPEUTICS

Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila

(2011) Haiqing Hua et al.   BIOMETALS

Prognostic value of the copper transporters, CTR1 and CTR2, in patients with ovarian carcinoma receiving platinum-based chemotherapy

(2011) Yoo-Young Lee et al.   GYNECOLOGIC ONCOLOGY

Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy

(2011) Helen H.W. Chen et al.   LUNG CANCER

Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis

(2011) Takamitsu Miyayama et al.   Metallomics

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

(2011) M. E. Palm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator

(2010) Seiko Ishida et al.   CANCER CELL

Regulation of Copper Transporter 2 Expression by Copper and Cisplatin in Human Ovarian Carcinoma Cells

(2010) B. G. Blair et al.   MOLECULAR PHARMACOLOGY

Copper Transporter 2 Regulates Endocytosis and Controls Tumor Growth and Sensitivity to Cisplatin In Vivo

(2010) B. G. Blair et al.   MOLECULAR PHARMACOLOGY

Therapeutic Targeting of ATP7B in Ovarian Carcinoma

(2009) L. S. Mangala et al.   CLINICAL CANCER RESEARCH

Copper Transporter 2 Regulates the Cellular Accumulation and Cytotoxicity of Cisplatin and Carboplatin

(2009) B. G. Blair et al.   CLINICAL CANCER RESEARCH

Copper-dependent Recycling of hCTR1, the Human High Affinity Copper Transporter

(2009) Shannon A. Molloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper redistribution in Atox1-deficient mouse fibroblast cells

(2009) Reagan McRae et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Crystal Structures of Cisplatin Bound to a Human Copper Chaperone

(2009) Amie K. Boal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three-dimensional structure of the human copper transporter hCTR1

(2009) C. J. De Feo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation

(2008) Shinichi Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of the loss of Atox1 on the cellular pharmacology of cisplatin

(2008) Roohangiz Safaei et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Role of the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-Based Drugs

(2008) C. A. Larson et al.   MOLECULAR PHARMACOLOGY