Clones of aging: When better fitness can be dangerous

Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold

(2023) Song Wu et al.   Cell Reports

Aging reduces liver resiliency by dysregulating Hedgehog signaling

(2022) Raquel Maeso‐Díaz et al.   AGING CELL

Clonal hematopoiesis: Mutation-specific adaptation to environmental change

(2022) Marcus A. Florez et al.   Cell Stem Cell

The longitudinal dynamics and natural history of clonal haematopoiesis

(2022) Margarete A. Fabre et al.   NATURE

Clonal dynamics of haematopoiesis across the human lifespan

(2022) Emily Mitchell et al.   NATURE

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

(2022) Ruzhica Bogeska et al.   Cell Stem Cell

The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

(2022) Fabio Marongiu et al.   Molecular Oncology

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

(2022) Siddhartha P. Kar et al.   NATURE GENETICS

The impact of inflammation-induced tumor plasticity during myeloid transformation

(2022) Anna Yeaton et al.   Cancer Discovery

Hypoxia-Regulated Tumor-Derived Exosomes and Tumor Progression: A Focus on Immune Evasion

(2022) Xuejun Shao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sleep exerts lasting effects on hematopoietic stem cell function and diversity

(2022) Cameron S. McAlpine et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

(2022) Kasumi Murai et al.   Nature Communications

Clonal hematopoiesis, somatic mosaicism, and age-associated disease

(2022) Megan A. Evans et al.   PHYSIOLOGICAL REVIEWS

TNF Receptors Choose HSC Fate in Supporting Dnmt3a-Mutant Clonal Hematopoiesis

(2022) Katia E. Niño et al.   Cancer Discovery

Inherent mosaicism and extensive mutation of human placentas

(2021) Tim H. H. Coorens et al.   NATURE

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease

(2021) Ahmed A. Z. Dawoud et al.   LEUKEMIA

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

(2021) Peter G. Miller et al.   BLOOD

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis

(2021) Peter Geon Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutant clones in normal epithelium outcompete and eliminate emerging tumours

(2021) B. Colom et al.   NATURE

When does a PNH clone have clinical significance?

(2021) Daria V. Babushok   Hematology-American Society of Hematology Education Program

Cell competition, cooperation, and cancer

(2021) Fabio Marongiu et al.   NEOPLASIA

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

(2020) Ezio Laconi et al.   BRITISH JOURNAL OF CANCER

Tobacco smoking and somatic mutations in human bronchial epithelium

(2020) Kenichi Yoshida et al.   NATURE

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

(2020) K. Brazhnik et al.   Science Advances

The mutational landscape of normal human endometrial epithelium

(2020) Luiza Moore et al.   NATURE

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

(2020) Tomoya Muto et al.   NATURE IMMUNOLOGY

The evolutionary dynamics and fitness landscape of clonal hematopoiesis

(2020) Caroline J. Watson et al.   SCIENCE

The role of stem cell niche in intestinal aging

(2020) Nalle Pentinmikko et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Macroscopic somatic clonal expansion in morphologically normal human urothelium

(2020) Ruoyan Li et al.   SCIENCE

Decoy fitness peaks, tumor suppression, and aging

(2019) Kelly C. Higa et al.   AGING CELL

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

Beneficial Noncancerous Mutations in Liver Disease

(2019) Miryam Müller et al.   TRENDS IN GENETICS

The Sleep-Immune Crosstalk in Health and Disease

(2019) Luciana Besedovsky et al.   PHYSIOLOGICAL REVIEWS

Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease

(2019) Siddhartha Jaiswal et al.   Nature Reviews Cardiology

Intestinal Stem Cell Aging: Origins and Interventions

(2019) Heinrich Jasper   Annual Review of Physiology

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Somatic mosaicism: implications for the cardiovascular system

(2019) Soichi Sano et al.   EUROPEAN HEART JOURNAL

An inflammatory environment containing TNFα favors Tet2 -mutant clonal hematopoiesis

(2018) Samuel O. Abegunde et al.   EXPERIMENTAL HEMATOLOGY

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

(2018) Rebecca Stephens et al.   JOURNAL OF MOLECULAR BIOLOGY

Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues

(2018) Ayana Sasaki et al.   Cell Reports

Aging and the rise of somatic cancer-associated mutations in normal tissues

(2018) Rosa Ana Risques et al.   PLoS Genetics

Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations

(2018) Kasumi Murai et al.   Cell Stem Cell

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

(2018) Kazuaki Suda et al.   Cell Reports

Biomarkers of Cellular Senescence and Skin Aging

(2018) Audrey S. Wang et al.   Frontiers in Genetics

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

(2018) Akira Yokoyama et al.   NATURE

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition

(2017) Masatoshi Yamamoto et al.   NATURE

Correction of aberrant growth preserves tissue homeostasis

(2017) Samara Brown et al.   NATURE

Cancer-Associated Mutations in Endometriosis without Cancer

(2017) Michael S. Anglesio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment

(2017) Erika Cadoni et al.   Oncotarget

Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis

(2017) Chao Zheng et al.   Scientific Reports

Aging promotes neoplastic disease through effects on the tissue microenvironment

(2016) Fabio Marongiu et al.   Aging-US

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

(2016) Jing Fang et al.   NATURE IMMUNOLOGY

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

(2016) H. Matsumura et al.   SCIENCE

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Cell-autonomous decrease in proliferative competitiveness of the aged hepatocyte

(2015) Maria Paola Serra et al.   JOURNAL OF HEPATOLOGY

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

(2015) Colin S Cooper et al.   NATURE GENETICS

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cdc42 is involved in basal cell carcinoma carcinogenesis

(2013) Maria Giovanna Tucci et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression

(2013) T. M. Regan Anderson et al.   CANCER RESEARCH

Helicobacter pylori-induced alteration of epithelial cell signaling and polarity: A possible mechanism of gastric carcinoma etiology and disparity

(2013) Mahasin A. Osman et al.   Cytoskeleton

Loss of the Par3 Polarity Protein Promotes Breast Tumorigenesis and Metastasis

(2012) Luke Martin McCaffrey et al.   CANCER CELL

Rho GTPase signaling in the development of colorectal cancer

(2012) Fernanda Leve et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cancer as a disease of tissue pattern formation

(2012) Fabio Marongiu et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Detection of the Onset of Ischemia and Carcinogenesis by Hypoxia-Inducible Transcription Factor-Based In Vivo Bioluminescence Imaging

(2011) Tetsuya Kadonosono et al.   PLoS One

The influence of donor age on liver regeneration and hepatic progenitor cell populations

(2011) Yoshihiro Ono et al.   SURGERY

Epithelial organization, cell polarity and tumorigenesis

(2011) Luke Martin McCaffrey et al.   TRENDS IN CELL BIOLOGY

Aging and liver regeneration

(2009) Nikolai A. Timchenko   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolic reprogramming, caloric restriction and aging

(2009) Rozalyn M. Anderson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Continuous Cell Injury Promotes Hepatic Tumorigenesis in Cdc42-Deficient Mouse Liver

(2008) Jolanda van Hengel et al.   GASTROENTEROLOGY

Cell polarity proteins: common targets for tumorigenic human viruses

(2008) R T Javier   ONCOGENE

The microenvironments of multistage carcinogenesis

(2008) Ezio Laconi et al.   SEMINARS IN CANCER BIOLOGY

Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression

(2008) Jennifer S. Fang et al.   SEMINARS IN CANCER BIOLOGY