p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition
出版年份 2022 全文链接
标题
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition
作者
关键词
-
出版物
Nature Communications
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-10-20
DOI
10.1038/s41467-022-33945-y
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mutant p53: it’s not all one and the same
- (2022) Margaret C. Kennedy et al. CELL DEATH AND DIFFERENTIATION
- Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells
- (2021) K. J. Pienta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- On the role of p53 in the cellular response to aneuploidy
- (2021) Akshay Narkar et al. Cell Reports
- Transient genomic instability drives tumorigenesis through accelerated clonal evolution
- (2021) Ofer Shoshani et al. GENES & DEVELOPMENT
- Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis
- (2021) Marianna Trakala et al. GENES & DEVELOPMENT
- AMPK-mTOR-mediated activation of autophagy promotes formation of dormant polyploid giant cancer cells
- (2021) Bo You et al. CANCER RESEARCH
- Mutant clones in normal epithelium outcompete and eliminate emerging tumours
- (2021) B. Colom et al. NATURE
- Tobacco smoking and somatic mutations in human bronchial epithelium
- (2020) Kenichi Yoshida et al. NATURE
- The mutational landscape of normal human endometrial epithelium
- (2020) Luiza Moore et al. NATURE
- Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium
- (2020) Bartomeu Colom et al. NATURE GENETICS
- A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice
- (2020) Gabriel Piedrafita et al. Nature Communications
- Extensive heterogeneity in somatic mutation and selection in the human bladder
- (2020) Andrew R. J. Lawson et al. SCIENCE
- Selection of oncogenic mutant clones in normal human skin varies with body site
- (2020) Joanna C Fowler et al. Cancer Discovery
- Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
- (2019) David Fernandez-Antoran et al. Cell Stem Cell
- Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
- (2019) Lawrence A. Donehower et al. Cell Reports
- A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies
- (2019) Steffen Boettcher et al. SCIENCE
- The landscape of somatic mutation in normal colorectal epithelial cells
- (2019) Henry Lee-Six et al. NATURE
- Genomic and Functional Approaches to Understanding Cancer Aneuploidy
- (2018) Alison M. Taylor et al. CANCER CELL
- Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer
- (2018) Katherine A. Hoadley et al. CELL
- MutationalPatterns: comprehensive genome-wide analysis of mutational processes
- (2018) Francis Blokzijl et al. Genome Medicine
- Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation
- (2018) Kailin R. Mesa et al. Cell Stem Cell
- Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations
- (2018) Kasumi Murai et al. Cell Stem Cell
- Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium
- (2018) Kazuaki Suda et al. Cell Reports
- Age-related remodelling of oesophageal epithelia by mutated cancer drivers
- (2018) Akira Yokoyama et al. NATURE
- Somatic mutant clones colonize the human esophagus with age
- (2018) Iñigo Martincorena et al. SCIENCE
- Germline TP53 mutations result into a constitutive defect of p53 DNA binding and transcriptional response to DNA damage
- (2017) Yasmine Zerdoumi et al. HUMAN MOLECULAR GENETICS
- Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
- (2017) Xi-Xi Chen et al. Nature Communications
- p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies
- (2017) Mar Soto et al. Cell Reports
- A single dividing cell population with imbalanced fate drives oesophageal tumour growth
- (2016) Julia Frede et al. NATURE CELL BIOLOGY
- Regulation of Cellular Metabolism and Hypoxia by p53
- (2016) Timothy J. Humpton et al. Cold Spring Harbor Perspectives in Medicine
- High burden and pervasive positive selection of somatic mutations in normal human skin
- (2015) I. Martincorena et al. SCIENCE
- Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
- (2015) Amanda M. Goh et al. Oncotarget
- CopywriteR: DNA copy number detection from off-target sequence data
- (2015) Thomas Kuilman et al. GENOME BIOLOGY
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Subclonal variant calling with multiple samples and prior knowledge
- (2014) M. Gerstung et al. BIOINFORMATICS
- DNA copy number analysis of fresh and formalin-fixed specimens by shallow whole-genome sequencing with identification and exclusion of problematic regions in the genome assembly
- (2014) Ilari Scheinin et al. GENOME RESEARCH
- Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change
- (2014) Maria P. Alcolea et al. NATURE CELL BIOLOGY
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- The Life History of 21 Breast Cancers
- (2012) Serena Nik-Zainal et al. CELL
- ZNF750 Is a p63 Target Gene that Induces KLF4 to Drive Terminal Epidermal Differentiation
- (2012) George L. Sen et al. DEVELOPMENTAL CELL
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium
- (2012) D. P. Doupe et al. SCIENCE
- The Ordered Architecture of Murine Ear Epidermis Is Maintained by Progenitor Cells with Random Fate
- (2010) David P. Doupé et al. DEVELOPMENTAL CELL
- Esophageal Squamous Cell Dysplasia and Delayed Differentiation With Deletion of Krüppel-Like Factor 4 in Murine Esophagus
- (2010) Marie–Pier Tetreault et al. GASTROENTEROLOGY
- The R246S hot-spot p53 mutant exerts dominant-negative effects in embryonic stem cells in vitro and in vivo
- (2008) M. K. Lee et al. JOURNAL OF CELL SCIENCE
- Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells
- (2008) B. R. Williams et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now