N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA

Recent Advances in Modified Cap Analogs: Synthesis, Biochemical Properties, and mRNA Based Vaccines

(2022) Muthian Shanmugasundaram et al.   CHEMICAL RECORD

N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering

(2022) Renata Grzela et al.   RNA

Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates

(2021) Magdalena Chrabąszczewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isoxazole-containing 5′ mRNA cap analogues as inhibitors of the translation initiation process

(2020) Karolina Piecyk et al.   BIOORGANIC CHEMISTRY

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

(2019) Beata Miedziak et al.   RNA

The recent progress of isoxazole in medicinal chemistry

(2018) Jie Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Modified ARCA analogs providing enhanced translational properties of capped mRNAs

(2018) Ilona Kocmik et al.   CELL CYCLE

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides

(2018) Renata Grzela et al.   RNA

mRNA cap regulation in mammalian cell function and fate

(2018) Alison Galloway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Isoxazole Derivatives as Regulators of Immune Functions

(2018) Michał Zimecki et al.   MOLECULES

Discovery of m7G-cap in eukaryotic mRNAs

(2015) Yasuhiro FURUICHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

mRNA transcript therapy

(2014) Drew Weissman   Expert Review of Vaccines

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Triazole-containing monophosphate mRNA cap analogs as effective translation inhibitors

(2014) Karolina Piecyk et al.   RNA

Synthesis of N2-modified 7-methylguanosine 5′-monophosphates as nematode translation inhibitors

(2012) Karolina Piecyk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

Structural basis for nematode eIF4E binding an m 2,2,7 G-Cap and its implications for translation initiation

(2011) Weizhi Liu et al.   NUCLEIC ACIDS RESEARCH

Copper-catalyzed azide–alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(i) acetylides

(2010) Jason E. Hein et al.   CHEMICAL SOCIETY REVIEWS

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

(2009) Joanna Kowalska et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

(2007) Gian Cesare Tron et al.   MEDICINAL RESEARCH REVIEWS