Centromere: A Trojan horse for genome stability

Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence

(2023) Xanita Saayman et al.   MOLECULAR CELL

ATR protects centromere identity by promoting DAXX association with PML nuclear bodies

(2023) Isabelle Trier et al.   Cell Reports

ERCC6L2 mitigates replication stress and promotes centromere stability

(2023) Christopher J. Carnie et al.   Cell Reports

CENP-B-mediated DNA loops regulate activity and stability of human centromeres

(2022) Florian Chardon et al.   MOLECULAR CELL

Complete genomic and epigenetic maps of human centromeres

(2022) Nicolas Altemose et al.   SCIENCE

Signatures of copy number alterations in human cancer

(2022) Christopher D. Steele et al.   NATURE

Telomere-to-telomere human DNA replication timing profiles

(2022) Dashiell J. Massey et al.   Scientific Reports

Polymer models reveal how chromatin modification can modulate force at the kinetochore

(2022) Josh Lawrimore et al.   MOLECULAR BIOLOGY OF THE CELL

Fragile sites, chromosomal lesions, tandem repeats, and disease

(2022) Mila Mirceta et al.   Frontiers in Genetics

Centromeric transcription maintains centromeric cohesion in human cells

(2021) Yujue Chen et al.   JOURNAL OF CELL BIOLOGY

Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

(2021) Sumedha Agashe et al.   Nature Communications

DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability

(2021) Barbara Ben Yamin et al.   EMBO JOURNAL

The RAD51 recombinase protects mitotic chromatin in human cells

(2021) Isabel E. Wassing et al.   Nature Communications

Variation and Evolution of Human Centromeres: A Field Guide and Perspective

(2021) Karen H. Miga et al.   Annual Review of Genetics

Diverse mechanisms of centromere specification

(2021) Barbara G. Mellone et al.   CURRENT BIOLOGY

Homologous recombination within repetitive DNA

(2021) Erica J Polleys et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Multi-scale dynamics of heterochromatin repair

(2021) Chiara Merigliano et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Chaperoning histones at the DNA repair dance

(2021) Ujani Chakraborty et al.   DNA REPAIR

A conserved mechanism for regulating replisome disassembly in eukaryotes

(2021) Michael Jenkyn-Bedford et al.   NATURE

Activation of homologous recombination in G1 preserves centromeric integrity

(2021) Duygu Yilmaz et al.   NATURE

BRCA1 prevents R-loop-associated centromeric instability

(2021) Carine Racca et al.   Cell Death & Disease

Epigenetic regulation of centromere function

(2020) Charmaine Yan Yu Wong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity

(2020) Louisa Nelson et al.   Nature Communications

From evolution to function: Two sides of the same CENP-B coin?

(2020) Riccardo Gamba et al.   EXPERIMENTAL CELL RESEARCH

Topoisomerase IIα is essential for maintenance of mitotic chromosome structure

(2020) Christian F. Nielsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

(2020) Åsa Ehlén et al.   Nature Communications

Centromeres under Pressure: Evolutionary Innovation in Conflict with Conserved Function

(2020) Elisa Balzano et al.   Genes

Centromeric Transcription: A Conserved Swiss-Army Knife

(2020) Ganesan Arunkumar et al.   Genes

Mismatch Repair Pathway, Genome Stability and Cancer

(2020) Nives Pećina-Šlaus et al.   Frontiers in Molecular Biosciences

A genetic memory initiates the epigenetic loop necessary to preserve centromere position

(2020) Sebastian Hoffmann et al.   EMBO JOURNAL

R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast

(2020) Prashant K. Mishra et al.   MOLECULAR BIOLOGY OF THE CELL

Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes

(2019) Tom D. Deegan et al.   MOLECULAR CELL

A tumor suppressive DNA translocase named FANCM

(2019) Jihane Basbous et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Centromeric Satellite DNAs: Hidden Sequence Variation in the Human Population

(2019) Miga   Genes

PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling

(2019) Owen Addis Jones et al.   Nature Communications

Plk1 protects kinetochore–centromere architecture against microtubule pulling forces

(2019) Robert F Lera et al.   EMBO REPORTS

Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination

(2019) Darren R. Heintzman et al.   Cell Reports

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Transposable elements: genome innovation, chromosome diversity, and centromere conflict

(2018) Savannah J. Klein et al.   CHROMOSOME RESEARCH

hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability

(2018) Zhengke Li et al.   EMBO JOURNAL

Non-B-Form DNA Is Enriched at Centromeres

(2018) Sivakanthan Kasinathan et al.   MOLECULAR BIOLOGY AND EVOLUTION

53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process

(2018) Ankana Tiwari et al.   Nature Communications

CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome

(2018) Motoko Unoki et al.   JOURNAL OF CLINICAL INVESTIGATION

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Mechanisms of DNA damage, repair, and mutagenesis

(2017) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

HJURP interaction with the condensin II complex during G1 promotes CENP-A deposition

(2017) Meghan C. Barnhart-Dailey et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage

(2017) Josh Lawrimore et al.   MOLECULAR BIOLOGY OF THE CELL

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

(2017) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Nuclear Dynamics of Heterochromatin Repair

(2017) Nuno Amaral et al.   TRENDS IN GENETICS

CENP-A chromatin disassembly in stressed and senescent murine cells

(2017) Sabrine Hédouin et al.   Scientific Reports

Alpha-CENTAURI: assessing novel centromeric repeat sequence variation with long read sequencing

(2016) Volkan Sevim et al.   BIOINFORMATICS

Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles

(2016) Megan E. Aldrup-MacDonald et al.   GENOME RESEARCH

Epigenome Maintenance in Response to DNA Damage

(2016) Juliette Dabin et al.   MOLECULAR CELL

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

(2016) Delphine Benarroch-Popivker et al.   MOLECULAR CELL

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

DNA damage signalling targets the kinetochore to promote chromatin mobility

(2016) Jonathan Strecker et al.   NATURE CELL BIOLOGY

The mutation spectrum in genomic late replication domains shapes mammalian GC content

(2016) Ephraim Kenigsberg et al.   NUCLEIC ACIDS RESEARCH

CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly

(2016) Sebastian Hoffmann et al.   Cell Reports

The Causes and Consequences of Topological Stress during DNA Replication

(2016) Andrea Keszthelyi et al.   Genes

Differential DNA lesion formation and repair in heterochromatin and euchromatin

(2015) Chunhua Han et al.   CARCINOGENESIS

Functions and regulation of the multitasking FANCM family of DNA motor proteins

(2015) Xiaoyu Xue et al.   GENES & DEVELOPMENT

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

The mechanism of DNA replication termination in vertebrates

(2015) James M. Dewar et al.   NATURE

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

(2015) S. J. Falk et al.   SCIENCE

Oncogenes create a unique landscape of fragile sites

(2015) Karin Miron et al.   Nature Communications

PTEN regulates DNA replication progression and stalled fork recovery

(2015) Jinxue He et al.   Nature Communications

The origins and processing of ultra fine anaphase DNA bridges

(2014) Ying Liu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

Loss of BRCA1 impairs centromeric cohesion and triggers chromosomal instability

(2014) Aurélie Di Paolo et al.   FASEB JOURNAL

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

(2014) K. Skourti-Stathaki et al.   GENES & DEVELOPMENT

Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation

(2014) Nehmé Saksouk et al.   MOLECULAR CELL

Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome

(2014) Indri Erliandri et al.   NUCLEIC ACIDS RESEARCH

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining

(2013) Angela Helfricht et al.   CELL CYCLE

The balancing act of DNA repeat expansions

(2013) Jane C Kim et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The N-terminal 45-kDa Domain of Dna2 Endonuclease/Helicase Targets the Enzyme to Secondary Structure DNA

(2013) Chul-Hwan Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Relationship of DNA Replication Timing to Different Forms of Human Mutation and Variation

(2012) Amnon Koren et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold

(2012) Tatsuya Nishino et al.   CELL

Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes

(2012) T.-M. Kim et al.   GENOME RESEARCH

Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication

(2012) Erin Walsh et al.   JOURNAL OF MOLECULAR BIOLOGY

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

(2012) R M Jones et al.   ONCOGENE

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the FANCM–MHF complex reveals physical features for functional assembly

(2012) Yuyong Tao et al.   Nature Communications

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

On the origins of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   CELL CYCLE

Give me a break, but not in mitosis

(2011) Simona Giunta et al.   CELL CYCLE

XenopusHJURP and condensin II are required for CENP-A assembly

(2011) Rafael Bernad et al.   JOURNAL OF CELL BIOLOGY

Cohesin's Concatenation of Sister DNAs Maintains Their Intertwining

(2011) Ana-Maria Farcas et al.   MOLECULAR CELL

Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1

(2011) Xiangduo Kong et al.   PLoS One

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage

(2010) Gayane Ambartsumyan et al.   HUMAN MOLECULAR GENETICS

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

(2010) L. H.-C. Wang et al.   JOURNAL OF CELL SCIENCE

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM

(2010) Thiyam Ramsing Singh et al.   MOLECULAR CELL

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

(2010) Zhijiang Yan et al.   MOLECULAR CELL

CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR

(2010) Mikel Zaratiegui et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution of Centromeric Proteins and PARP-1 during Mitosis and Apoptosis

(2009) Federica Perdoni et al.   Annals of the New York Academy of Sciences

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

(2009) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

Active establishment of centromeric CENP-A chromatin by RSF complex

(2009) Marinela Perpelescu et al.   JOURNAL OF CELL BIOLOGY

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation

(2009) Alexander Samoshkin et al.   PLoS One

Double-strand DNA breaks recruit the centromeric histone CENP-A

(2009) S. G. Zeitlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic regulation of heterochromatic DNA stability

(2008) Jamy C Peng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

Topoisomerase II Inactivation Prevents the Completion of DNA Replication in Budding Yeast

(2008) Jonathan Baxter et al.   MOLECULAR CELL