R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast

Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize

(2020) Yalin Liu et al.   PLOS BIOLOGY

Point centromere activity requires an optimal level of centromeric noncoding RNA

(2019) Yick Hin Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

Protein kinases in mitotic phosphorylation of budding yeast CENP-A

(2019) Prashant K. Mishra et al.   CURRENT GENETICS

The regulation of chromosome segregation via centromere loops

(2019) Josh Lawrimore et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Saccharomyces cerevisiae Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding

(2019) Chi-Fu Chen et al.   GENETICS

R-Loops Promote Antisense Transcription across the Mammalian Genome

(2019) Sue Mei Tan-Wong et al.   MOLECULAR CELL

R-Loops as Promoters of Antisense Transcription

(2019) Ana G. Rondón et al.   MOLECULAR CELL

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

(2019) Leonid Andronov et al.   Nature Communications

Kinetochore-associated Stu2 promotes chromosome biorientation in vivo

(2019) Matthew P. Miller et al.   PLoS Genetics

Budding yeast CENP-ACse4 interacts with the N-terminus of Sgo1 and regulates its association with centromeric chromatin

(2018) Prashant K. Mishra et al.   CELL CYCLE

A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A

(2018) Sultan Ciftci-Yilmaz et al.   GENETICS

A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A

(2018) Sultan Ciftci-Yilmaz et al.   GENETICS

Geometric partitioning of cohesin and condensin are a consequence of chromatin loops

(2018) Josh Lawrimore et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability

(2018) Lorenzo Costantino et al.   MOLECULAR CELL

Centromeric and ectopic assembly of CENP-A chromatin in health and cancer: old marks and new tracks

(2018) Abhishek Bharadwaj Sharma et al.   NUCLEIC ACIDS RESEARCH

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Histone Mutants Separate R Loop Formation from Genome Instability Induction

(2017) Desiré García-Pichardo et al.   MOLECULAR CELL

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Polo kinase Cdc5 associates with centromeres to facilitate the removal of centromeric cohesin during mitosis

(2016) Prashant K. Mishra et al.   MOLECULAR BIOLOGY OF THE CELL

Pat1 protects centromere-specific histone H3 variant Cse4 from Psh1-mediated ubiquitination

(2015) Prashant K. Mishra et al.   MOLECULAR BIOLOGY OF THE CELL

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Topology and Global Architecture of Point Centromeres

(2015) Ofelia Díaz-Ingelmo et al.   Cell Reports

Out of Balance: R-loops in Human Disease

(2014) Matthias Groh et al.   PLoS Genetics

Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip

(2014) Yujia A. Chan et al.   PLoS Genetics

Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria

(2014) Aziz El Hage et al.   PLoS Genetics

Chromosomal Instability, Aneuploidy, and Cancer

(2014) Samuel F. Bakhoum et al.   Frontiers in Oncology

A 3D Map of the Yeast Kinetochore Reveals the Presence of Core and Accessory Centromere-Specific Histone

(2013) Julian Haase et al.   CURRENT BIOLOGY

Structural Integrity of Centromeric Chromatin and Faithful Chromosome Segregation Requires Pat1

(2013) P. K. Mishra et al.   GENETICS

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants

(2012) P. C. Stirling et al.   GENES & DEVELOPMENT

Interactions Between the Kinetochore Complex and the Protein Kinase A Pathway in Saccharomyces cerevisiae

(2012) Lina Ma et al.   G3-Genes Genomes Genetics

R-loop-mediated genomic instability is caused by impairment of replication fork progression

(2011) W. Gan et al.   GENES & DEVELOPMENT

A Role for Histone H4K16 Hypoacetylation inSaccharomyces cerevisiaeKinetochore Function

(2011) John S. Choy et al.   GENETICS

Point centromeres contain more than a single centromere-specific Cse4 (CENP-A) nucleosome

(2011) Josh Lawrimore et al.   JOURNAL OF CELL BIOLOGY

Histone H3-variant Cse4-induced positive DNA supercoiling in the yeast plasmid has implications for a plasmid origin of a chromosome centromere

(2011) C.-C. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misregulation of Scm3p/HJURP Causes Chromosome Instability in Saccharomyces cerevisiae and Human Cells

(2011) Prashant K. Mishra et al.   PLoS Genetics

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain

(2010) Prerana Ranjitkar et al.   MOLECULAR CELL

Centromeric Nucleosomes Induce Positive DNA Supercoils

(2009) Takehito Furuyama et al.   CELL

The S-Phase Checkpoint Is Required To Respond to R-Loops Accumulated in THO Mutants

(2009) B. Gomez-Gonzalez et al.   MOLECULAR AND CELLULAR BIOLOGY

Pericentromeric Sister Chromatid Cohesion Promotes Kinetochore Biorientation

(2009) Tessie M. Ng et al.   MOLECULAR BIOLOGY OF THE CELL

Pericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis

(2008) Elaine Yeh et al.   CURRENT BIOLOGY

Altered Dosage and Mislocalization of Histone H3 and Cse4p Lead to Chromosome Loss in Saccharomyces cerevisiae

(2008) W.-C. Au et al.   GENETICS