ERCC6L2 mitigates replication stress and promotes centromere stability

CellProfiler 4: improvements in speed, utility and usability

(2021) David R. Stirling et al.   BMC BIOINFORMATICS

Activation of homologous recombination in G1 preserves centromeric integrity

(2021) Duygu Yilmaz et al.   NATURE

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication

(2020) Amaia Ercilla et al.   Cell Reports

ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells

(2020) Xiaojing Liu et al.   CELL RESEARCH

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis

(2020) Claudia Baumann et al.   Nature Communications

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining

(2020) Paola Francica et al.   Cell Reports

ERCC6L2 defines a novel entity within inherited acute myeloid leukemia

(2019) Suvi P. M. Douglas et al.   BLOOD

Using combined evidence from replicates to evaluate ChIP-seq peaks

(2018) Vahid Jalili et al.   BIOINFORMATICS

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

(2018) Rajat Gupta et al.   CELL

hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability

(2018) Zhengke Li et al.   EMBO JOURNAL

FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1‐defective cells

(2018) Junya Tomida et al.   EMBO JOURNAL

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

(2018) Harveer Dev et al.   NATURE CELL BIOLOGY

Genome-wide analysis of replication timing by next-generation sequencing with E/L Repli-seq

(2018) Claire Marchal et al.   Nature Protocols

KAP1 facilitates reinstatement of heterochromatin after DNA replication

(2018) Suk Min Jang et al.   NUCLEIC ACIDS RESEARCH

Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelicERCC6L2variants

(2018) Hemanth Tummala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERCC6L2 -associated inherited bone marrow failure syndrome

(2018) Iren Shabanova et al.   Molecular Genetics & Genomic Medicine

SHLD2/FAM35A co‐operates with REV7 to coordinate DNA double‐strand break repair pathway choice

(2018) Steven Findlay et al.   EMBO JOURNAL

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

(2018) Hind Ghezraoui et al.   NATURE

The shieldin complex mediates 53BP1-dependent DNA repair

(2018) Sylvie M. Noordermeer et al.   NATURE

An OB-fold complex controls the repair pathways for DNA double-strand breaks

(2018) Shengxian Gao et al.   Nature Communications

The role of fork stalling and DNA structures in causing chromosome fragility

(2018) Simran Kaushal et al.   GENES CHROMOSOMES & CANCER

Repetitive Fragile Sites: Centromere Satellite DNA As a Source of Genome Instability in Human Diseases

(2018) Elizabeth M. Black et al.   Genes

The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells

(2017) Chenhui Huang et al.   EXPERIMENTAL CELL RESEARCH

Chromatin and nucleosome dynamics in DNA damage and repair

(2017) Michael H. Hauer et al.   GENES & DEVELOPMENT

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

(2017) Ying Wai Chan et al.   NATURE CELL BIOLOGY

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

(2017) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the function of ZRANB3 in replication stress response

(2017) Marek Sebesta et al.   Nature Communications

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

A nonsense mutation in the DNA repair factor Hebo causes mild bone marrow failure and microcephaly

(2016) Shu Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

A simple method for generating high-resolution maps of genome-wide protein binding

(2015) Peter J Skene et al.   eLife

MASSIF-1: a beamline dedicated to the fully automatic characterization and data collection from crystals of biological macromolecules

(2015) Matthew W. Bowler et al.   JOURNAL OF SYNCHROTRON RADIATION

ERCC6L2 Mutations Link a Distinct Bone-Marrow-Failure Syndrome to DNA Repair and Mitochondrial Function

(2014) Hemanth Tummala et al.   AMERICAN JOURNAL OF HUMAN GENETICS

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

(2014) Alexandre Maréchal et al.   CELL RESEARCH

PTIP associates with Artemis to dictate DNA repair pathway choice

(2014) Jiadong Wang et al.   GENES & DEVELOPMENT

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

Centromere fragmentation is a common mitotic defect of S and G2checkpoint override

(2013) Neil Beeharry et al.   CELL CYCLE

The balancing act of DNA repeat expansions

(2013) Jane C Kim et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome

(2013) Bari J. Ballew et al.   PLoS Genetics

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response

(2012) R. Weston et al.   GENES & DEVELOPMENT

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas

(2011) C. Martinez-A et al.   CARCINOGENESIS

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Epigenetic Centromere Propagation and the Nature of CENP-A Nucleosomes

(2011) Ben E. Black et al.   CELL

The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation

(2011) D. White et al.   MOLECULAR CANCER RESEARCH

Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability

(2011) R B Slee et al.   ONCOGENE

New insights into the formation and resolution of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Mechanisms of trinucleotide repeat instability during human development

(2010) Cynthia T. McMurray   NATURE REVIEWS GENETICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Identification of a novel, widespread, and functionally important PCNA-binding motif

(2009) Karin M. Gilljam et al.   JOURNAL OF CELL BIOLOGY

Identification of sister chromatids by DNA template strand sequences

(2009) Ester Falconer et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Characterization of chromosomes and chromosomal fragments in human lymphocyte micronuclei by telomeric and centromeric FISH

(2008) H. K. Lindberg et al.   MUTAGENESIS

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY