标题
Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy
作者
关键词
-
出版物
MEDICINAL RESEARCH REVIEWS
Volume 36, Issue 6, Pages 1036-1079
出版商
Wiley
发表日期
2016-07-13
DOI
10.1002/med.21399
参考文献
相关参考文献
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- Aurora Kinase A Promotes Inflammation and Tumorigenesis in Mice and Human Gastric Neoplasia
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- Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cellsviaAKT signaling
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- Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma
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- Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer
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- The pan-Aurora kinase inhibitor, PHA-739358, induces apoptosis and inhibits migration in melanoma cell lines
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- Inhibition of mTOR Pathway Sensitizes Acute Myeloid Leukemia Cells to Aurora Inhibitors by Suppression of Glycolytic Metabolism
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- AMG 900, a Small-Molecule Inhibitor of Aurora Kinases, Potentiates the Activity of Microtubule-Targeting Agents in Human Metastatic Breast Cancer Models
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- The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly
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- Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer
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- Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells
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- MLN8054, A Small Molecule Inhibitor of Aurora Kinase A, Sensitizes Androgen-Resistant Prostate Cancer to Radiation
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- Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells
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- Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation
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- A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines
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- AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma
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- The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-Amplified Neuroblastoma In Vivo
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- Curcumin-Induced Mitotic Spindle Defect and Cell Cycle Arrest in Human Bladder Cancer Cells Occurs Partly through Inhibition of Aurora A
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- Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
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- Regulation of APC/CCdc20 activity by RASSF1A–APC/CCdc20 circuitry
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- In vitroandin vivopharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases
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- Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237
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- Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state
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- A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma
- (2010) G. Gorgun et al. BLOOD
- Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma
- (2010) Xiaojing Wang et al. BRITISH JOURNAL OF HAEMATOLOGY
- Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors
- (2010) E. Claire Dees et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors
- (2010) Anne M. Traynor et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
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- Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
- (2010) M. Payton et al. CANCER RESEARCH
- The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
- (2010) L.-h. Wang et al. CANCER RESEARCH
- Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells
- (2010) Patrizia Cammareri et al. CANCER RESEARCH
- Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cellsin vitro
- (2010) Mariko Tomita et al. CANCER SCIENCE
- Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E
- (2010) Yumi Kim et al. CELL
- Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2
- (2010) G. Yang et al. CLINICAL CANCER RESEARCH
- Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of ENMD-2076, a Novel Angiogenic and Aurora Kinase Inhibitor,in Patients with Advanced Solid Tumors
- (2010) J. R. Diamond et al. CLINICAL CANCER RESEARCH
- Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry
- (2010) Doris Kinzel et al. DEVELOPMENTAL CELL
- Suppression of Aurora-A oncogenic potential by c-Myc downregulation
- (2010) Shangbin Yang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Aurora-A overexpression and aneuploidy predict poor outcome in serous ovarian carcinoma
- (2010) Heini Lassus et al. GYNECOLOGIC ONCOLOGY
- Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib
- (2010) Neeltje Steeghs et al. INVESTIGATIONAL NEW DRUGS
- The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib
- (2010) Kevin R. Kelly et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Discovery ofN-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors
- (2010) Shudong Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Regulation of the Aurora-A gene following topoisomerase I inhibition: implication of the Myc transcription Factor
- (2010) Sandy Courapied et al. Molecular Cancer
- MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo
- (2010) J. J. Huck et al. MOLECULAR CANCER RESEARCH
- Activity of the Aurora Kinase Inhibitor VX-680 against Bcr/Abl-Positive Acute Lymphoblastic Leukemias
- (2010) F. Fei et al. MOLECULAR CANCER THERAPEUTICS
- ENMD-2076 Is an Orally Active Kinase Inhibitor with Antiangiogenic and Antiproliferative Mechanisms of Action
- (2010) G. C. Fletcher et al. MOLECULAR CANCER THERAPEUTICS
- PF-03814735, an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer Therapy
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- The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program
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- Aurora-A expression, hormone receptor status and clinical outcome in hormone related cancers
- (2010) Kakoli Das et al. PATHOLOGY
- Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies
- (2010) I. Astsaturov et al. Science Signaling
- Impact of the expression of Aurora-A, p53, and MIB-1 on the prognosis of urothelial carcinomas of the upper urinary tract
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- Correlation between Aurora-A expression and the prognosis of cervical carcinoma patients
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- Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
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- SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo
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- Aurora A Regulates Prometaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity
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- Phase I Pharmacokinetic and Pharmacodynamic Study of the Aurora Kinase Inhibitor Danusertib in Patients With Advanced or Metastatic Solid Tumors
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- Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I
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- Aurora Kinase A Inhibition Leads to p73-Dependent Apoptosis in p53-Deficient Cancer Cells
- (2008) Altaf A. Dar et al. CANCER RESEARCH
- Inhibition of Aurora-A suppresses epithelial–mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells
- (2008) Xiang-Bo Wan et al. CARCINOGENESIS
- Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization
- (2008) Frederik Wirtz-Peitz et al. CELL
- Expression of Aurora A (but Not Aurora B) Is Predictive of Survival in Breast Cancer
- (2008) Y. Nadler et al. CLINICAL CANCER RESEARCH
- APC/CCdh1 Targets Aurora Kinase to Control Reorganization of the Mitotic Spindle at Anaphase
- (2008) Suzanne Floyd et al. CURRENT BIOLOGY
- Expression of Aurora kinase A and B in normal and malignant cervical tissue: High Aurora A kinase expression in squamous cervical cancer
- (2008) Nae-Fang Twu et al. European Journal of Obstetrics & Gynecology and Reproductive Biology
- Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma
- (2008) Abhijit Mazumdar et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity†
- (2008) Steven Howard et al. JOURNAL OF MEDICINAL CHEMISTRY
- ConsensusPathDB—a database for integrating human functional interaction networks
- (2008) Atanas Kamburov et al. NUCLEIC ACIDS RESEARCH
- Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry
- (2008) A. Seki et al. SCIENCE
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