Aurora kinase targeting in lung cancer reduces KRAS-induced transformation

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer

(2015) Brittany M. Bowman et al.   Science Signaling

Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer

(2015) Brittany M. Bowman et al.   Science Signaling

EGFR-mutated lung cancer: a paradigm of molecular oncology

(2015)   Oncotarget

Identification of aurora kinase A as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors

(2015) Chun-Nan Yeh et al.   Oncotarget

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 – 2013)

(2014) Chun Hei Antonio Cheung et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle

(2014) G. Wang et al.   JOURNAL OF CELL SCIENCE

The Prognostic Impact of KRAS, Its Codon and Amino Acid Specific Mutations, on Survival in Resected Stage I Lung Adenocarcinoma

(2014) Benjamin Izar et al.   Journal of Thoracic Oncology

Aurora kinase A mediates c-Myc's oncogenic effects in hepatocellular carcinoma

(2014) Longfeng Lu et al.   MOLECULAR CARCINOGENESIS

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability

(2014) M. Munoz-Barrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals

(2013) I. Perez de Castro et al.   CANCER RESEARCH

The Investigational Aurora Kinase A Inhibitor MLN8237 Induces Defects in Cell Viability and Cell-Cycle Progression in Malignant Bladder Cancer Cells In Vitro and In Vivo

(2013) N. Zhou et al.   CLINICAL CANCER RESEARCH

Let7a inhibits the growth of endometrial carcinoma cells by targetingAurora-B

(2013) Ping Liu et al.   FEBS LETTERS

RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis

(2013) Gong Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer

(2013) Masafumi Takeshita et al.   LUNG CANCER

Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle

(2013) H. Hochegger et al.   Open Biology

Chromosome Instability Modulated by BMI1-AURKA Signaling Drives Progression in Head and Neck Cancer

(2012) C.-H. Chou et al.   CANCER RESEARCH

Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target

(2012) A. V. Patel et al.   CLINICAL CANCER RESEARCH

Danusertib, an aurora kinase inhibitor

(2012) Hielke J Meulenbeld et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Aurora kinase inhibitors: Progress towards the clinic

(2012) Madhu Kollareddy et al.   INVESTIGATIONAL NEW DRUGS

LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy

(2012) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Aurora B kinase phosphorylates and instigates degradation of p53

(2012) C. P. Gully et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aurora B: A New Prognostic Marker and Therapeutic Target in Cancer

(2011) G. Portella et al.   CURRENT MEDICINAL CHEMISTRY

Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation

(2011) Marco Lo Iacono et al.   Journal of Translational Medicine

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

(2010) J. den Hollander et al.   BLOOD

Stable knockdown of Aurora-A by vector-based RNA interference in human esophageal squamous cell carcinoma cell line inhibits tumor cell proliferation, invasion and enhances apoptosis

(2010) Xiaoxia Wang et al.   CANCER BIOLOGY & THERAPY

ALK Inhibition for Non-Small Cell Lung Cancer: From Discovery to Therapy in Record Time

(2010) David E. Gerber et al.   CANCER CELL

RasV12 induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance

(2010) Réda Hadj-Slimane et al.   CELLULAR SIGNALLING

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

(2010) Tony Sourisseau et al.   EMBO Molecular Medicine

Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy

(2010) Anat Biran et al.   INTERNATIONAL JOURNAL OF CANCER

Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer

(2010) Christopher P Gully et al.   Molecular Cancer

Aurora-A overexpression enhances cell-aggregation of Ha-rastransformants through the MEK/ERK signaling pathway

(2009) Ya-Shih Tseng et al.   BMC CANCER

AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo

(2009) A. Oke et al.   CANCER RESEARCH

Deregulated Aurora-B induced tetraploidy promotes tumorigenesis

(2009) Hao G. Nguyen et al.   FASEB JOURNAL

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

(2009) K.-H. Lim et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

(2008) J. A. Engelman et al.   CLINICAL CANCER RESEARCH