Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis

(2016) Marjolein Garsen et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase

(2013) Jennifer C. Wilson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity

(2013) Kenneth K.C. Bramwell et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of heparanase and the endothelial glycocalyx in the development of proteinuria

(2013) Marjolein Garsen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Synthesis of a Pseudo-Disaccharide Library and Its Application to the Characterisation of the Heparanase Catalytic Site

(2013) Victoria Vinader et al.   PLoS One

Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues

(2013) Edward Hammond et al.   FEBS Open Bio

Structure–activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors

(2011) Tiehai Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

(2011) N. Gil et al.   DIABETES

(1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-d-glucitol (TS-071) is a Potent, Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for Type 2 Diabetes Treatment

(2010) Hiroyuki Kakinuma et al.   JOURNAL OF MEDICINAL CHEMISTRY