Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease

TEMPORARY REMOVAL: Therapeutic opportunities for the treatment of NASH with genetically validated targets

(2023) Daniel Lindén et al.   JOURNAL OF HEPATOLOGY

Are there outcome differences between NAFLD and metabolic‐associated fatty liver disease?

(2022) Zobair M. Younossi et al.   HEPATOLOGY

GLP-1 Receptor Agonists and Coronary Arteries: From Mechanisms to Events

(2022) Aurélie Pahud de Mortanges et al.   Frontiers in Pharmacology

Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner

(2022) Adel Abo Mansour et al.   BIOMEDICINE & PHARMACOTHERAPY

Immunomodulatory functions of FXR

(2022) Stefano Fiorucci et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation

(2022) Fen Yang et al.   JACC-Basic to Translational Science

GLP-1 Receptor Agonists for the Reduction of Atherosclerotic Cardiovascular Risk in Patients With Type 2 Diabetes

(2022) Nikolaus Marx et al.   CIRCULATION

Acute high fat diet impairs macrophage supported intestinal damage resolution

(2022) Andrea A. Hill et al.   JCI Insight

Bile acids and their receptors in metabolic disorders

(2021) Stefano Fiorucci et al.   PROGRESS IN LIPID RESEARCH

Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies

(2021) Youngmin A. Lee et al.   JOURNAL OF INTERNAL MEDICINE

Linking liver metabolic and vascular disease via bile acid signaling

(2021) Stefano Fiorucci et al.   TRENDS IN MOLECULAR MEDICINE

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

(2020) Giovanni Sorrentino et al.   GASTROENTEROLOGY

T cell subsets and functions in atherosclerosis

(2020) Ryosuke Saigusa et al.   Nature Reviews Cardiology

Association of serum fibroblast growth factor 19 levels with arteriosclerosis parameters assessed by arterial stiffness and atherogenic index of plasma in patients with type 2 diabetes

(2020) Wang-shu Liu et al.   Diabetology & Metabolic Syndrome

Characterisation of endogenous Galectin-1 and -9 expression in monocyte and macrophage subsets under resting and inflammatory conditions

(2020) Franziska Krautter et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut Microbiota in Hypertension and Atherosclerosis: A Review

(2020) Barbara J. H. Verhaar et al.   Nutrients

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

(2019) Patricia D. Finn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis

(2019) Mei Zhou et al.   JOURNAL OF LIPID RESEARCH

High-fat diet promotes experimental colitis by inducing oxidative stress in the colon

(2019) Xue Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E−/- mice

(2019) Manse Kim et al.   BIOMATERIALS

Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis

(2019) Mohammad Shadab Siddiqui et al.   JOURNAL OF HEPATOLOGY

Disbiome database: linking the microbiome to disease

(2018) Yorick Janssens et al.   BMC MICROBIOLOGY

Bile acids in glucose metabolism in health and disease

(2018) Hagit Shapiro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

(2018) Jonathan D Roth et al.   WORLD JOURNAL OF GASTROENTEROLOGY

seq-ImmuCC: Cell-Centric View of Tissue Transcriptome Measuring Cellular Compositions of Immune Microenvironment From Mouse RNA-Seq Data

(2018) Ziyi Chen et al.   Frontiers in Immunology

Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis

(2018) Adriana Carino et al.   FASEB JOURNAL

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

Role of TGR5 (GPBAR1) in Liver Disease

(2018) Dieter Häussinger et al.   SEMINARS IN LIVER DISEASE

Animal models of atherosclerosis

(2017) Besa Emini Veseli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

Nanotraps with biomimetic surface as decoys for chemokines

(2017) Ivan Guryanov et al.   Nanomedicine-Nanotechnology Biology and Medicine

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis

(2016) Giovanni Targher et al.   JOURNAL OF HEPATOLOGY

Plasma membrane-bound G protein-coupled bile acid receptor attenuates liver ischemia/reperfusion injury via the inhibition of toll-like receptor 4 signaling in mice

(2016) Haojun Yang et al.   LIVER TRANSPLANTATION

Role of gut microbiota in atherosclerosis

(2016) Annika Lindskog Jonsson et al.   Nature Reviews Cardiology

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

(2016) Yuri V. Bobryshev et al.   Biomed Research International

Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: A systematic review and meta-analysis

(2016) Shunquan Wu et al.   Scientific Reports

Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids

(2015) Barbara Renga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1

(2015) Barbara Renga et al.   PLoS One

Exploitation of Cholane Scaffold for the Discovery of Potent and Selective Farnesoid X Receptor (FXR) and G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) Ligands

(2014) Carmen Festa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1)

(2014) Valentina Sepe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice

(2013) Tiangang Li et al.   HEPATOLOGY

NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

(2012) Geoffrey C. Farrell et al.   Gut and Liver

Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery

(2012) Ting Gui et al.   MEDIATORS OF INFLAMMATION

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

Inflammatory Mediators and Insulin Resistance in Obesity: Role of Nuclear Receptor Signaling in Macrophages

(2010) Lucía Fuentes et al.   MEDIATORS OF INFLAMMATION

Antiatherosclerotic effect of farnesoid X receptor

(2008) Andrea Mencarelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS