NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

(2011) Timea Csak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet

(2011) Joel R. Garbow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Transcriptional Profile of Genes Involved in Oxidative Stress and Antioxidant Defense in a Dietary Murine Model of Steatohepatitis

(2011) Agnieszka Gornicka et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of oxidative stress in non-alcoholic steatohepatitis

(2011) G.H. Koek et al.   CLINICA CHIMICA ACTA

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease

(2011) D. M. S. Ferreira et al.   DIABETOLOGIA

Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet

(2011) Nicolas Lanthier et al.   FASEB JOURNAL

Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease

(2011) Mark J. Czaja   GASTROENTEROLOGY

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography

(2011) Vincent Wai-Sun Wong et al.   GUT

Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis

(2011) Mary E. Rinella et al.   HEPATOLOGY

Diagnosing steatohepatitis and predicting liver-related mortality in patients with NAFLD: Two distinct concepts

(2011) Paul Angulo   HEPATOLOGY

Hepatic endoplasmic reticulum stress in obesity: Deeper insights into processes, but are they relevant to nonalcoholic steatohepatitis?

(2011) Isabelle A. Leclercq et al.   HEPATOLOGY

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

(2011) Cheng Ji et al.   HEPATOLOGY

Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis

(2011) Diana Joka et al.   HEPATOLOGY

The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study

(2011) Neeraj Bhala et al.   HEPATOLOGY

Telomerase gene mutations are associated with cirrhosis formation

(2011) Daniel Hartmann et al.   HEPATOLOGY

Nuclear factor high-mobility group box1 mediating the activation of toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice

(2011) Liang Li et al.   HEPATOLOGY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality

(2011) Zobair M. Younossi et al.   HEPATOLOGY

Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase

(2011) David A. Brenner et al.   HEPATOLOGY RESEARCH

Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease

(2011) Leon A Adams et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Histological features of non-alcoholic fatty liver disease: What is important?

(2011) Etsuko Hashimoto et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan

(2011) Takeshi Okanoue et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

(2011) Hartmut Jaeschke   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground

(2011) Shivakumar Chitturi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Peroxisome proliferator-activated receptor-α agonist, Wy 14 643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis

(2011) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review

(2011) Christian Thoma et al.   JOURNAL OF HEPATOLOGY

Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice

(2011) Matam Vijay-Kumar et al.   Journal of Inflammation-London

Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice

(2011) Michaela C Stanton et al.   Journal of Inflammation-London

The effect of ezetimibe, administered alone or in combination with simvastatin, on lymphocyte cytokine release in patients with elevated cholesterol levels

(2011) R. Krysiak et al.   JOURNAL OF INTERNAL MEDICINE

Increased production of sonic hedgehog by ballooned hepatocytes

(2011) Fatima Rangwala et al.   JOURNAL OF PATHOLOGY

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

(2011) George M. Philips et al.   PLoS One

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Cell death and nonalcoholic steatohepatitis: where is ballooning relevant?

(2011) Mariana Verdelho Machado et al.   Expert Review of Gastroenterology & Hepatology

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity

(2010) Giovanni Musso et al.   ANNALS OF MEDICINE

New Insights from Rodent Models of Fatty Liver Disease

(2010) Jacquelyn J. Maher   ANTIOXIDANTS & REDOX SIGNALING

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging

(2010) Antero Salminen et al.   CELLULAR SIGNALLING

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice

(2010) Kristiaan Wouters et al.   FEBS LETTERS

Stress Signaling in the Methionine-Choline–Deficient Model of Murine Fatty Liver Disease

(2010) Russell K. Soon et al.   GASTROENTEROLOGY

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease

(2010) Giovanni Targher et al.   HEPATOLOGY

High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial

(2010) Ulrich F. H. Leuschner et al.   HEPATOLOGY

Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease

(2010) Brent A. Neuschwander-Tetri et al.   HEPATOLOGY

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

(2010) Elizabeth K. Speliotes et al.   HEPATOLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis

(2010) Leon A. Adams et al.   Hepatology International

Does non-alcoholic fatty liver disease predispose patients to type 2 diabetes in the absence of obesity?

(2010) Jian-Gao Fan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A fresh look at NASH pathogenesis. Part 1: The metabolic movers

(2010) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Transient elastography

(2010) Vincent Wai-Sun Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Biomarkers of liver fibrosis

(2010) Leon A Adams   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatocellular ballooning in NASH

(2010) Stephen Caldwell et al.   JOURNAL OF HEPATOLOGY

Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia–reperfusion injury

(2010) Laura Llacuna et al.   JOURNAL OF HEPATOLOGY

Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis

(2010) Lisa Lo et al.   JOURNAL OF HEPATOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome

(2009) Michael B Fessler et al.   CURRENT OPINION IN LIPIDOLOGY

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

(2009) K. Kantartzis et al.   DIABETES

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

(2009) A. Kotronen et al.   DIABETOLOGIA

The Inflamed Liver and Atherosclerosis: A Link Between Histologic Severity of Nonalcoholic Fatty Liver Disease and Increased Cardiovascular Risk

(2009) Naim Alkhouri et al.   DIGESTIVE DISEASES AND SCIENCES

Characterization of High-Fat, Diet-Induced, Non-alcoholic Steatohepatitis with Fibrosis in Rats

(2009) Zheng-Jie Xu et al.   DIGESTIVE DISEASES AND SCIENCES

Heritability of Nonalcoholic Fatty Liver Disease

(2009) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

Heme Oxygenase-1 Protects Against Steatohepatitis in Both Cultured Hepatocytes and Mice

(2009) Jun Yu et al.   GASTROENTEROLOGY

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Lipidomic dissection of nonalcoholic steatohepatitis: Moving beyond foie gras to fat traffic

(2009) Nathan M. Bass   HEPATOLOGY

Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis

(2009) Stephen H. Caldwell et al.   HEPATOLOGY

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Adipokines in liver diseases

(2009) Fabio Marra et al.   HEPATOLOGY

Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease

(2009) Vincent Wai-Sun Wong et al.   HEPATOLOGY

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression

(2009) Geoffrey C Farrell et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Clues from the carotids: An appraisal of cardiovascular disease risk in non-alcoholic fatty liver disease

(2009) Shivakumar Chitturi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Lipotoxicity: Why do saturated fatty acids cause and monounsaturates protect against it?

(2009) Christopher J Nolan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice

(2009) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

(2009) Curtis K. Argo et al.   JOURNAL OF HEPATOLOGY

Signalling pathways in alcohol-induced liver inflammation

(2009) Pranoti Mandrekar et al.   JOURNAL OF HEPATOLOGY

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

(2009) Francisco Caballero et al.   JOURNAL OF HEPATOLOGY

Signaling Crosstalk during Sequential TLR4 and TLR9 Activation Amplifies the Inflammatory Response of Mouse Macrophages

(2009) D. De Nardo et al.   JOURNAL OF IMMUNOLOGY

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis

(2009) Michael K. Pickens et al.   JOURNAL OF LIPID RESEARCH

Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice

(2009) Wing-Kin Syn et al.   LIVER INTERNATIONAL

Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury

(2009) Justin D. Ellett et al.   LIVER TRANSPLANTATION

Variant in PNPLA3 is associated with alcoholic liver disease

(2009) Chao Tian et al.   NATURE GENETICS

Liver NF-κB and AP-1 DNA Binding in Obese Patients

(2009) Luis A. Videla et al.   Obesity

Non-alcoholic fatty liver disease from pathogenesis to management: an update

(2009) G. Musso et al.   Obesity Reviews

TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY

(2009) Thiruma V. Arumugam et al.   SHOCK

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Cytokines in the Pathogenesis of Fatty Liver and Disease Progression to Steatohepatitis: Implications for Treatment

(2008) Christine Carter-Kent et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

(2008) Xin Yuan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent

(2008) Laura H. Tetri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Elevated alanine aminotransferase levels predict mortality from cardiovascular disease and diabetes in Koreans

(2008) Kyung Eun Yun et al.   ATHEROSCLEROSIS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Location, Location, Location…

(2008) Ruth B.S. Harris et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Inflammatory signaling and cellular senescence

(2008) Jian-Lin Ren et al.   CELLULAR SIGNALLING

Inflammatory Pathways in Liver Homeostasis and Liver Injury

(2008) Frank Tacke et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation

(2008) Montserrat Marí et al.   GASTROENTEROLOGY

Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance

(2008) J L Newton et al.   GUT

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network

(2008) Elizabeth M. Brunt et al.   HEPATOLOGY

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

(2008) Jacquelyn J. Maher et al.   HEPATOLOGY

Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes

(2008) Sophie Clément et al.   HEPATOLOGY

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

(2008) Kristiaan Wouters et al.   HEPATOLOGY

Non-alcoholic steatohepatitis and animal models: Understanding the human disease

(2008) Marta Varela-Rey et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Animal models of NASH: Getting both pathology and metabolic context right

(2008) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis

(2008) Carolin Lackner et al.   JOURNAL OF HEPATOLOGY

Hepatic free fatty acids accumulate in experimental steatohepatitis: Role of adaptive pathways

(2008) Claire Z. Larter et al.   JOURNAL OF HEPATOLOGY

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

(2008) Naga Chalasani et al.   JOURNAL OF HEPATOLOGY

Trans-11 Vaccenic Acid Dietary Supplementation Induces Hypolipidemic Effects in JCR:LA-cp Rats

(2008) Ye Wang et al.   JOURNAL OF NUTRITION

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY

Activation of peroxisome proliferator-activated receptor α by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation

(2007) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Visceral adipose tissue area is an independent risk factor for hepatic steatosis

(2007) Bum J Park et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY