ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease

Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence

(2023) Insup Choi et al.   NATURE CELL BIOLOGY

Molecular landscapes of human hippocampal immature neurons across lifespan

(2022) Yi Zhou et al.   NATURE

ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice

(2021) Keertana Srimat Kandadai et al.   Autophagy

Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover

(2021) Ainhoa Plaza-Zabala et al.   Frontiers in Immunology

Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction

(2021) Chenran Wang et al.   Autophagy

Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading

(2021) Yin Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

(2021) J. Terreros-Roncal et al.   SCIENCE

Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation

(2021) Hang Liu et al.   Scientific Reports

Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice

(2020) Jinbo Cheng et al.   Autophagy

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

(2020) Ya-Ting Wang et al.   Nature Microbiology

Sex differences in autophagy-mediated diseases: toward precision medicine

(2020) Dangtong Shang et al.   Autophagy

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

(2020) Insup Choi et al.   Nature Communications

Aging and sex: Impact on microglia phagocytosis

(2020) Natalia Yanguas‐Casás et al.   AGING CELL

Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease

(2020) Yue Qin et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation

(2020) Rasmus Berglund et al.   Science Immunology

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3

(2019) Judith Houtman et al.   EMBO JOURNAL

Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations

(2019) Ramon Velazquez et al.   MOLECULAR PSYCHIATRY

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Deficits in Enrichment-Dependent neurogenesis and enhanced Anxiety behaviors mediated by expression of Alzheimer's disease-linked PS1 variants are rescued by Microglial Depletion

(2019) Sylvia Ortega-Martinez et al.   JOURNAL OF NEUROSCIENCE

Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers

(2019) Chiara Scopa et al.   CELL DEATH AND DIFFERENTIATION

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Microglial microRNAs mediate sex-specific responses to tau pathology

(2019) Lay Kodama et al.   NATURE NEUROSCIENCE

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

(2018) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice

(2018) Joanna Ruth Appel et al.   JOURNAL OF NEUROSCIENCE

Sex differences in Alzheimer disease — the gateway to precision medicine

(2018) Maria Teresa Ferretti et al.   Nature Reviews Neurology

Impaired Hippocampal Neurogenesis and its Enhancement with Ghrelin in 5XFAD Mice

(2018) Minho Moon et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Impairments of Hippocampal Neurogenesis in 5xFAD Mouse Model of Alzheimer’s Disease Are Associated with Altered Expression of SOXB Transcription Factors

(2018) Ivan Zaletel et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

(2018) Silvia S. Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Autophagy gene FIP200 in neural progenitors non–cell autonomously controls differentiation by regulating microglia

(2017) Chenran Wang et al.   JOURNAL OF CELL BIOLOGY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

(2017) Colleen A. Mangold et al.   Journal of Neuroinflammation

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition

(2017) Carolyn Hollands et al.   Molecular Neurodegeneration

Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide

(2017) Jose Viña et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurons exhibitLyz2promoter activity in vivo: Implications for using LysM-Cre mice in myeloid cell research

(2016) Johannes Orthgiess et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Amyloid-β suppresses AMP-activated protein kinase (AMPK) signaling and contributes to α-synuclein-induced cytotoxicity

(2016) Chih-Li Lin et al.   EXPERIMENTAL NEUROLOGY

Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model

(2016) Song Chen et al.   GENES & DEVELOPMENT

Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

(2016) Chenran Wang et al.   JOURNAL OF CELL BIOLOGY

Sex differences in Alzheimer's disease and other dementias

(2016) Carolyn M Mazure et al.   LANCET NEUROLOGY

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease

(2015) Laura K. Hamilton et al.   Cell Stem Cell

Effects of Microglia on Neurogenesis

(2015) Kaoru Sato   GLIA

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

(2015) Jacqueline M. Kimmey et al.   NATURE

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

The Experimental Autoimmune Encephalomyelitis Disease Course Is Modulated by Nicotine and Other Cigarette Smoke Components

(2014) Zhen Gao et al.   PLoS One

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

FIP200 is required for maintenance and differentiation of postnatal neural stem cells

(2013) Chenran Wang et al.   NATURE NEUROSCIENCE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

The role of microglia in adult hippocampal neurogenesis

(2013) Carmelina Gemma et al.   Frontiers in Cellular Neuroscience

Impaired Performance of Female APP/PS1 Mice in the Morris Water Maze Is Coupled with Increased A� Accumulation and Microglial Activation

(2012) J.J. Gallagher et al.   Neurodegenerative Diseases

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Regulation of Integrin β1 Recycling to Lipid Rafts by Rab1a to Promote Cell Migration

(2010) Chenran Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH