Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs

1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity

(2023) Aaron F. Carlin et al.   Journal of Medicinal Chemistry

The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants

(2022) Liu Cao et al.   Science Translational Medicine

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

(2022) Alexandra Schäfer et al.   Science Translational Medicine

SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus

(2022) Emilie Branche et al.   Nature Communications

VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19

(2022) Zhujun Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs

(2021) Robert T. Schooley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients

(2021) Robert L. Gottlieb et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

(2021) Robert M. Cox et al.   Nature Communications

Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524)

(2021) Michael K. Lo et al.   Microbiology Spectrum

Potent in vitro activity of β-D-4ʹ-chloromethyl-2ʹ-deoxy-2ʹ-fluorocytidine against Nipah virus

(2020) Michael K. Lo et al.   ANTIVIRAL RESEARCH

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

(2020) Jason D. Goldman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

(2020) Richard T. Eastman et al.   ACS Central Science

Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID‐19, in Healthy Subjects

(2020) Rita Humeniuk et al.   CTS-Clinical and Translational Science

Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19

(2020) Massimo Tempestilli et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post-treatment hospitalisation status

(2020) Spinello Antinori et al.   PHARMACOLOGICAL RESEARCH

Acetylcysteine for the Treatment of Suspected Remdesivir‐Associated Acute Liver Failure in COVID‐19: A Case Series

(2020) Chancey Carothers et al.   PHARMACOTHERAPY

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

(2017) Dustin Siegel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a reverse genetics system to generate a recombinant Ebola virus Makona expressing a green fluorescent protein

(2015) César G. Albariño et al.   VIROLOGY

Evaluation of luciferase and GFP-expressing Nipah viruses for rapid quantitative antiviral screening

(2014) Michael K. Lo et al.   ANTIVIRAL RESEARCH

The Pathology of Severe Dengue in Multiple Organs of Human Fatal Cases: Histopathology, Ultrastructure and Virus Replication

(2014) Tiago F. Póvoa et al.   PLoS One

Dendritic Cells in Dengue Virus Infection: Targets of Virus Replication and Mediators of Immunity

(2014) Michael A. Schmid et al.   Frontiers in Immunology