The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants
出版年份 2022 全文链接
标题
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants
作者
关键词
-
出版物
Science Translational Medicine
Volume -, Issue -, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2022-05-17
DOI
10.1126/scitranslmed.abm7621
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Regular and booster vaccination with inactivated vaccines enhance the neutralizing activity against Omicron variant both in the breakthrough infections and vaccinees
- (2022) YangYang et al. JOURNAL OF INFECTION
- Considerable escape of SARS-CoV-2 Omicron to antibody neutralization
- (2022) Delphine Planas et al. NATURE
- Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization
- (2022) Sandile Cele et al. NATURE
- Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
- (2022) Yunlong Cao et al. NATURE
- Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2
- (2022) Lihong Liu et al. NATURE
- Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice
- (2022) Alexandra Schäfer et al. Science Translational Medicine
- Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice
- (2021) Pratima Kumari et al. Viruses-Basel
- Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
- (2021) Goran Kokic et al. Nature Communications
- AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19
- (2021) Steven S. Good et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models
- (2021) Yingjun Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
- (2021) Angela Wahl et al. NATURE
- GS-441524 inhibits African swine fever virus infection in vitro
- (2021) Zhao Huang et al. ANTIVIRAL RESEARCH
- Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
- (2021) Richard L. Mackman et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery
- (2021) Yun-Yun Jin et al. VIROLOGICA SINICA
- Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs
- (2021) Robert T. Schooley et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2
- (2021) Daibao Wei et al. BIOORGANIC & MEDICINAL CHEMISTRY
- How the Delta variant achieves its ultrafast spread
- (2021) Sara Reardon NATURE
- Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
- (2021) Florian Kabinger et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern
- (2021) Matthew McCallum et al. SCIENCE
- Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2
- (2021) Yuanchao Xie et al. CELL RESEARCH
- Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation
- (2021) Akatsuki Saito et al. NATURE
- Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients
- (2021) Robert L. Gottlieb et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
- (2021) Robert M. Cox et al. Nature Communications
- Covid-19: Omicron is causing more infections but fewer hospital admissions than delta, South African data show
- (2021) Owen Dyer BMJ-British Medical Journal
- Covid-19: Hospital admission 50-70% less likely with omicron than delta, but transmission a major concern
- (2021) Elisabeth Mahase BMJ-British Medical Journal
- Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- (2020) Manli Wang et al. CELL RESEARCH
- A new coronavirus associated with human respiratory disease in China
- (2020) Fan Wu et al. NATURE
- The Architecture of SARS-CoV-2 Transcriptome
- (2020) Dongwan Kim et al. CELL
- A Mouse Model of SARS-CoV-2 Infection and Pathogenesis
- (2020) Shi-Hui Sun et al. Cell Host & Microbe
- Remdesivir for 5 or 10 Days in Patients with Severe Covid-19
- (2020) Jason D. Goldman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment
- (2020) Jing Sun et al. CELL
- Emerging coronaviruses: Genome structure, replication, and pathogenesis
- (2020) Yu Chen et al. JOURNAL OF MEDICAL VIROLOGY
- Coronavirus RNA proofreading: molecular basis and therapeutic targeting
- (2020) Fran Robson et al. MOLECULAR CELL
- Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
- (2020) Andrea J. Pruijssers et al. Cell Reports
- Favipiravir versus other antiviral or standard of care for COVID-19 treatment: a rapid systematic review and meta-analysis
- (2020) Dhan Bahadur Shrestha et al. Virology Journal
- Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge
- (2020) Francesca Picarazzi et al. MOLECULES
- Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC–MS/MS
- (2020) Wenjuan Hu et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis
- (2019) Niels C Pedersen et al. JOURNAL OF FELINE MEDICINE AND SURGERY
- The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies
- (2018) B.G. Murphy et al. VETERINARY MICROBIOLOGY
- The ProTide Prodrug Technology: Where Next?
- (2018) Ashwag S. Alanazi et al. ACS Medicinal Chemistry Letters
- Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
- (2017) Timothy P. Sheahan et al. Science Translational Medicine
- GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo- and Paramyxoviruses
- (2017) Michael K. Lo et al. Scientific Reports
- Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution
- (2014) Jaffar A. Al-Tawfiq et al. TRENDS IN MICROBIOLOGY
- Prodrug Design Targeting Intestinal PepT1 for Improved Oral Absorption: Design and Performance
- (2013) Youxi Zhang et al. CURRENT DRUG METABOLISM
- Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides
- (2012) Aesop Cho et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Coronaviruses post-SARS: update on replication and pathogenesis
- (2009) Stanley Perlman et al. NATURE REVIEWS MICROBIOLOGY
- Ester Bonds in Prodrugs
- (2008) Luke D. Lavis ACS Chemical Biology
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